Lista de obras - Celine Valant - Dominio Público Uruguay

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists

artículo científico publicado en 2009

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

artículo científico publicado en 2008

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

artículo científico publicado en 2016

Activation and allosteric modulation of a muscarinic acetylcholine receptor

artículo científico publicado en 2013

Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration

scientific article published on 01 October 2009

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

artículo científico publicado en 2010

Allosteric modulation of endogenous metabolites as an avenue for drug discovery.

artículo científico publicado en 2012

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

artículo científico publicado en 2009

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors.

artículo científico publicado en 2018

Crystal structure of the M5 muscarinic acetylcholine receptor

scientific article published on 26 November 2019

Endogenous allosteric modulators of G protein-coupled receptors

artículo científico publicado en 2015

Label-Free Kinetics: Exploiting Functional Hemi-Equilibrium to Derive Rate Constants for Muscarinic Receptor Antagonists

artículo científico publicado en 2015

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

artículo científico publicado en 2014

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

scientific article published on June 2009

Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

artículo científico publicado en 2011

Positive allosteric mechanisms of adenosine A<sub>1</sub> receptor-mediated analgesia

artículo científico publicado en 2021

Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.

artículo científico publicado en 2011

Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects

artículo científico publicado en 2011

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

artículo científico publicado en 2013

Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.

artículo científico publicado en 2013

Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist

scientific article published on 11 March 2014

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

artículo científico publicado en 2013

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

artículo científico publicado en 2012

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004.

artículo científico publicado en 2015

Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M ₁ muscarinic acetylcholine receptor.

artículo científico publicado en 2014

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

artículo científico publicado en 2013

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

artículo científico publicado en 2021

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

artículo científico publicado en 2011

Lista de obras de Celine Valant

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

Allosteric modulation of endogenous metabolites as an avenue for drug discovery.

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors.

Crystal structure of the M5 muscarinic acetylcholine receptor

Endogenous allosteric modulators of G protein-coupled receptors

Label-Free Kinetics: Exploiting Functional Hemi-Equilibrium to Derive Rate Constants for Muscarinic Receptor Antagonists

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

Positive allosteric mechanisms of adenosine A<sub>1</sub> receptor-mediated analgesia

Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.

Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.

Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004.

Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M ₁ muscarinic acetylcholine receptor.

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.