Lista de obras - D Merk - Dominio Público Uruguay

A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter non-alcoholic steatohepatitis

artículo científico

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)

artículo científico publicado en 2018

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

artículo científico publicado en 2018

Chances and challenges of retinoid X receptor gamma targeting for regenerative multiple sclerosis treatment.

artículo científico publicado en 2015

Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms

artículo científico publicado en 2020

Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics

scientific article published on 14 June 2018

Computer-Assisted Selective Optimization of Side-Activities-from Cinalukast to a PPARα Modulator

artículo científico publicado en 2019

De Novo Design of Bioactive Small Molecules by Artificial Intelligence.

artículo científico publicado en 2018

Design and Structural Optimization of Dual FXR/PPARδ Activators

artículo científico publicado en 2020

Design of Natural-Product-Inspired Multitarget Ligands by Machine Learning

scientific article published on 16 May 2019

Development of Nuclear Receptor Modulators

article

Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning

scientific article published on 02 October 2018

Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning

artículo científico publicado en 2018

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

scientific article published on 17 September 2019

DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators

artículo científico publicado en 2017

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

scientific article published on 19 November 2019

Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties

artículo científico publicado en 2015

Innovations in the Treatment of Cystic Fibrosis: Outriders for the Treatment of Diseases with Other Genetic Defects? ⬇️

artículo científico publicado el 1 de diciembre de 2011

Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists

artículo científico publicado en 2014

New Hope Or Drawbacks: Will Chronic Kidney Disease Be Treatable with Small Molecules In The Near Future? ⬇️

artículo científico publicado el 1 de marzo de 2012

Non-agonist inhibitors of Cdk5-dependent phosphorylation of PPAR as insulin sensitizers in the future?

artículo científico publicado el 1 de mayo de 2012

Nonacidic Farnesoid X Receptor Modulators

artículo científico publicado en 2017

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).

artículo científico publicado en 2013

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators

artículo científico publicado en 2012

Nuclear Receptors As Pharmaceutical Targets: Rise Of FXR And Rebirth Of PPAR? ⬇️

artículo científico publicado el 1 de abril de 2012

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.

artículo científico publicado en 2017

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

artículo científico publicado en 2018

Optical control of the nuclear bile acid receptor FXR with a photohormone

artículo científico publicado en 2019

Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity

artículo científico publicado en 2014

Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds

artículo científico publicado en 2018

Prospective de novo drug design with deep interactome learning

artículo científico publicado en 2024

SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.

artículo científico publicado en 2016

Scaffold hopping from synthetic RXR modulators by virtual screening and design

artículo científico publicado en 2018

Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation

artículo científico publicado en 2018

Selective optimization of Pranlukast to farnesoid X receptor modulators

artículo científico publicado en 2018

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

artículo científico publicado en 2018

Therapeutic applications of the versatile fatty acid mimetic WY14643.

artículo científico publicado en 2016

Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present).

artículo científico publicado en 2012

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation

scientific article published on 15 February 2019

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

artículo científico publicado en 2018

Lista de obras de D Merk

A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter non-alcoholic steatohepatitis

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

Chances and challenges of retinoid X receptor gamma targeting for regenerative multiple sclerosis treatment.

Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms

Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics

Computer-Assisted Selective Optimization of Side-Activities-from Cinalukast to a PPARα Modulator

De Novo Design of Bioactive Small Molecules by Artificial Intelligence.

Design and Structural Optimization of Dual FXR/PPARδ Activators

Design of Natural-Product-Inspired Multitarget Ligands by Machine Learning

Development of Nuclear Receptor Modulators

Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning

Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties

Innovations in the Treatment of Cystic Fibrosis: Outriders for the Treatment of Diseases with Other Genetic Defects? ⬇️

Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists

New Hope Or Drawbacks: Will Chronic Kidney Disease Be Treatable with Small Molecules In The Near Future? ⬇️

Non-agonist inhibitors of Cdk5-dependent phosphorylation of PPAR as insulin sensitizers in the future?

Nonacidic Farnesoid X Receptor Modulators

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators

Nuclear Receptors As Pharmaceutical Targets: Rise Of FXR And Rebirth Of PPAR? ⬇️

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

Optical control of the nuclear bile acid receptor FXR with a photohormone

Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity

Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds

Prospective de novo drug design with deep interactome learning

SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.

Scaffold hopping from synthetic RXR modulators by virtual screening and design

Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation

Selective optimization of Pranlukast to farnesoid X receptor modulators

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

Therapeutic applications of the versatile fatty acid mimetic WY14643.

Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present).

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro