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Lista de obras de Matthijs Verhage

A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment

artículo científico publicado en 2015

A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity

scientific article published on 21 February 2020

A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells

artículo científico publicado en 2015

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

scientific article published on 01 May 2019

A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice.

scientific article published on 15 February 2017

A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion

artículo científico publicado en 2013

A solution to dependency: using multilevel analysis to accommodate nested data

artículo científico publicado en 2014

AHCODA-DB: a data repository with web-based mining tools for the analysis of automated high-content mouse phenomics data

artículo científico publicado en 2017

Activity-dependent recruitment of endogenous glutamate for exocytosis ⬇️

artículo científico publicado el 1 de enero de 1991

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

artículo científico publicado en 2015

Automated analysis of neuronal morphology, synapse number and synaptic recruitment

artículo científico publicado en 2010

Automated analysis of secretory vesicle distribution at the ultrastructural level.

artículo científico publicado en 2008

Automated quantification of cellular traffic in living cells.

artículo científico publicado en 2008

Ba2+ replaces Ca2+/calmodulin in the activation of protein phosphatases and in exocytosis of all major transmitters

scientific article published on 01 November 1995

Bidirectional modulation of classical fear conditioning in mice by 5-HT(1A) receptor ligands with contrasting intrinsic activities.

artículo científico publicado en 2009

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons

scientific journal article

CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons

artículo científico publicado en 2017

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane.

artículo científico publicado en 2004

Ca2+-dependent regulation of presynaptic stimulus-secretion coupling

artículo científico publicado en 1989

CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles

artículo científico publicado en 2020

Characterization of the release of Met-enkephalin from isolated nerve terminals: release kinetics and cation-dependence

artículo científico publicado el 11 de diciembre de 1992

Characterization of the release of cholecystokinin-8 from isolated nerve terminals and comparison with exocytosis of classical transmitters.

artículo científico publicado en 1991

Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures.

artículo científico publicado en 2009

Cognitive flexibility deficits in a mouse model for the absence of full-length dystrophin

artículo científico publicado en 2016

Complex Genetics of Behavior: BXDs in the Automated Home-Cage.

artículo científico publicado en 2017

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

artículo científico publicado en 2008

Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

artículo científico publicado en 2015

Correction: CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.

artículo científico publicado en 2015

Correction: MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10 (doi:10.1242/jcs.234674)

artículo científico publicado en 2019

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

artículo científico publicado en 2018

Crashpilot Underachieves due to Acetylation at the Nerve Terminal ⬇️

artículo científico publicado el 8 de diciembre de 2011

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

artículo científico publicado en 2014

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties

artículo científico publicado en 2006

Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality.

artículo científico publicado en 2011

Dendritic position is a major determinant of presynaptic strength.

artículo científico publicado en 2012

Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.

artículo científico publicado en 2017

Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion

scientific journal article

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons.

artículo científico publicado en 2017

Differential distribution and regulation of expression of synaptosomal-associated protein of 25 kDa isoforms in the Xenopus pituitary gland and brain.

artículo científico publicado en 2004

Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice

Display of individuality in avoidance behavior and risk assessment of inbred mice

artículo científico publicado en 2014

Dissecting docking and tethering of secretory vesicles at the target membrane.

artículo científico publicado en 2006

Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons

artículo científico publicado en 2020

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.

artículo científico publicado en 2017

Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength

scientific article published on 08 October 2019

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

artículo científico publicado en 2010

Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity

artículo científico publicado en 2012

Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release

artículo científico publicado en 2013

Docking of secretory vesicles is syntaxin dependent

artículo científico publicado en 2006

Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25.

artículo científico publicado en 2017

Endogenous noradrenaline and dopamine in nerve terminals of the hippocampus: differences in levels and release kinetics.

artículo científico publicado en 1992

Evaluation of the Ca2+ concentration in purified nerve terminals: relationship between Ca2+ homeostasis and synaptosomal preparation

artículo científico publicado en 1988

Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.

artículo científico publicado en 2016

FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain

artículo científico publicado en 2013

Fast vesicle fusion in living cells requires at least three SNARE complexes

artículo científico publicado en 2010

Fatty acids add grease to exocytosis

artículo científico publicado en 2005

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.

artículo científico publicado en 2019

Finding the right motivation: genotype-dependent differences in effective reinforcements for spatial learning

artículo científico publicado en 2011

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

artículo científico publicado en 2015

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.

artículo científico publicado en 2011

Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability

artículo científico publicado en 2010

Functional gene-set analysis does not support a major role for synaptic function in attention deficit/hyperactivity disorder (ADHD).

artículo científico publicado en 2014

Gene-set analysis shows association between FMRP targets and autism spectrum disorder

artículo científico publicado en 2017

Genes encoding heterotrimeric G-proteins are associated with gray matter volume variations in the medial frontal cortex

artículo científico publicado en 2012

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

artículo científico publicado en 2013

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

scientific article published on 27 August 2019

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission

artículo científico publicado en 2020

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

artículo científico publicado en 2017

Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes

artículo científico publicado en 2015

Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticity

artículo científico publicado en 2007

Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder

artículo científico publicado en 2009

Kindling increases the K(+)-evoked Ca2(+)-dependent release of endogenous GABA in area CA1 of rat hippocampus.

artículo científico publicado en 1990

Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission

artículo científico publicado en 2013

Loss of MUNC18-1 leads to retrograde transport defects in neurons

artículo científico publicado en 2020

MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

artículo científico publicado en 2018

MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10

scientific article published on 02 December 2019

Matrix-dependent local retention of secretory vesicle cargo in cortical neurons

artículo científico publicado en 2009

Measuring discrimination- and reversal learning in mouse models within 4 days and without prior food deprivation.

artículo científico publicado en 2016

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

artículo científico publicado en 2010

Molecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretion

artículo científico publicado en 2012

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells.

artículo científico publicado en 2017

Multilevel analysis quantifies variation in the experimental effect while optimizing power and preventing false positives

artículo científico publicado en 2015

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats? ⬇️

artículo científico publicado el 9 de agosto de 2011

Munc13 controls the location and efficiency of dense-core vesicle release in neurons

artículo científico publicado en 2012

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

artículo científico publicado en 2017

Munc18 and Munc13 regulate early neurite outgrowth

artículo científico publicado en 2010

Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

scientific journal article

Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

artículo científico publicado en 2007

Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release

artículo científico publicado en 2014

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

artículo científico publicado en 2012

Munc18-1 phosphorylation by protein kinase C potentiates vesicle pool replenishment in bovine chromaffin cells.

artículo científico publicado en 2006

Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner

artículo científico publicado en 2014

Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms

artículo científico publicado en 2012

Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation

artículo científico publicado en 2005

Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming.

artículo científico publicado en 2007

Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.

artículo científico publicado en 2015

Neurobeachin regulates neurotransmitter receptor trafficking to synapses.

artículo científico publicado en 2012

Neurodegeneration: new road leads back to the synapse.

artículo científico publicado en 2012

Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.

artículo científico publicado en 2016

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

artículo científico publicado en 2020

Organelle docking: R-SNAREs are late.

artículo científico publicado en 2009

Perfusion of immobilized isolated nerve terminals as a model for the regulation of transmitter release: release of different, endogenous transmitters, repeated stimulation, and high time resolution

artículo científico publicado el 1 de abril de 1992

Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies

artículo científico publicado en 2010

Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity

artículo científico publicado en 2016

Pool size estimations for dense-core vesicles in mammalian CNS neurons

scientific article published on 05 September 2018

Power in GWAS: lifting the curse of the clinical cut-off.

artículo científico publicado en 2012

Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.

artículo científico publicado en 2016

Presynaptic plasticity: the regulation of Ca(2+)-dependent transmitter release.

artículo científico publicado en 1994

Presynaptic signal transduction pathways that modulate synaptic transmission.

scientific article published on 24 June 2009

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy.

artículo científico publicado en 2018

Publisher Correction: Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner

artículo científico publicado en 2019

Quantification of synapse formation and maintenance in vivo in the absence of synaptic release

scientific journal article

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

artículo científico publicado en 2018

Rab3 Proteins Involved in Vesicle Biogenesis and Priming in Embryonic Mouse Chromaffin Cells

artículo científico publicado en 2010

Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals.

artículo científico publicado en 2001

Reduced Protein Stability of 11 Pathogenic Missense STXBP1/MUNC18-1 Variants and Improved Disease Prediction

artículo científico publicado en 2024

Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.

artículo científico publicado en 2006

Reduced synaptic depression in human neurons carrying homozygous disease-causing <i>STXBP1</i> variant L446F

artículo científico publicado en 2024

Regulated exocytosis: merging ideas on fusing membranes.

artículo científico publicado en 2007

Role of Munc18-1 in synaptic plasticity at the myasthenic neuromuscular junction

scientific article published on 01 September 2003

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering

scientific article published on 01 August 2019

SNAP-25 gene family members differentially support secretory vesicle fusion.

artículo científico publicado en 2017

SNAREopathies: Diversity in Mechanisms and Symptoms

scientific article published on 12 June 2020

Secretory vesicle trafficking in awake and anaesthetized mice: differential speeds in axons versus synapses

artículo científico publicado en 2018

Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring

artículo científico publicado en 2014

Somatodendritic secretion in oxytocin neurons is upregulated during the female reproductive cycle.

artículo científico publicado en 2003

Spatial, contextual and working memory are not affected by the absence of mossy fiber long-term potentiation and depression.

artículo científico publicado en 2003

Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25.

artículo científico publicado en 2012

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

artículo científico publicado en 2019

Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.

artículo científico publicado en 2012

Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons

artículo científico publicado en 2015

Synaptic assembly of the brain in the absence of neurotransmitter secretion

artículo científico publicado en 2000

Synaptobrevin, Sphingolipids, and Secretion: Lube ‘n’ Go at the Synapse

artículo científico publicado en 2009

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.

artículo científico publicado en 2013

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

artículo científico publicado en 2009

Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner

artículo científico publicado en 2019

TRIM3 regulates the motility of the kinesin motor protein KIF21B

artículo científico publicado en 2013

Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons

artículo científico publicado en 2020

Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action ⬇️

artículo científico publicado el 25 de octubre de 1992

The Action Radius of Oxytocin Release in the Mammalian CNS: From Single Vesicles to Behavior

artículo científico publicado en 2017

The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.

artículo científico publicado en 2014

The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

scientific article published on 31 October 2019

The SNARE protein vti1a functions in dense-core vesicle biogenesis

artículo científico publicado en 2014

The light spot test: Measuring anxiety in mice in an automated home-cage environment

artículo científico publicado en 2015

The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitary.

artículo científico publicado en 2005

The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1.

artículo científico publicado en 2007

The role of calcium and cAMP in the mechanism of action of two melanocortins: alpha MSH and the ACTH4-9 analogue Org 2766

artículo científico publicado en 1994

Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.

artículo científico publicado en 2017

Tomosyn interacts with the SUMO E3 ligase PIASγ.

artículo científico publicado en 2014

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

artículo científico publicado en 2014

Trophic support delays but does not prevent cell-intrinsic degeneration of neurons deficient for munc18-1

scientific journal article

Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

artículo científico publicado en 2005

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.

artículo científico publicado en 2017

Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons

artículo científico publicado en 2019

Vesicle docking in regulated exocytosis.

artículo científico publicado en 2008

Vesicle trafficking: pleasure and pain from SM genes.

artículo científico publicado en 2003

Vesicular trafficking of semaphorin 3A is activity-dependent and differs between axons and dendrites.

artículo científico publicado en 2006

Vti Proteins: Beyond Endolysosomal Trafficking

artículo científico publicado en 2018

Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

artículo científico publicado en 2018

Within-strain variation in behavior differs consistently between common inbred strains of mice

artículo científico publicado en 2015

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