Lista de obras - Edward Rebar - Dominio Público Uruguay

A TALE nuclease architecture for efficient genome editing

artículo científico publicado en 2011

A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.

artículo científico publicado en 2012

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

artículo científico publicado en 2012

A rapid and general assay for monitoring endogenous gene modification

artículo científico publicado en 2010

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease

scientific article published on 01 July 2019

An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice.

artículo científico publicado en 2006

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

artículo científico publicado en 2010

An improved zinc-finger nuclease architecture for highly specific genome editing

artículo científico publicado en 2007

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

artículo científico publicado en 2015

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

artículo científico publicado en 2015

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

artículo científico publicado en 2011

Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics

artículo científico publicado en 2002

Designed transcription factors as tools for therapeutics and functional genomics

artículo científico publicado en 2002

Development of pro-angiogenic engineered transcription factors for the treatment of cardiovascular disease

artículo científico publicado en 2004

Diversifying the structure of zinc finger nucleases for high-precision genome editing

scientific article published on 08 March 2019

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. ⬇️

artículo científico publicado en 2011

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

artículo científico publicado en 2009

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

artículo científico publicado en 2011

Enhancing gene editing specificity by attenuating DNA cleavage kinetics

scientific article published on 29 July 2019

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

artículo científico publicado en 2008

Functional footprinting of regulatory DNA.

artículo científico publicado en 2015

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

artículo científico publicado en 2010

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

artículo científico publicado en 2016

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

artículo científico publicado en 2006

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

artículo científico publicado en 2011

Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application

artículo científico publicado en 2016

Genetic engineering of human pluripotent cells using TALE nucleases

artículo científico publicado en 2011

Genome editing with engineered zinc finger nucleases

artículo científico publicado en 2010

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

artículo científico publicado en 2008

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells

artículo científico publicado en 2014

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

artículo científico publicado en 2015

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

artículo científico publicado en 2015

In vivo genome editing restores haemostasis in a mouse model of haemophilia

artículo científico publicado en 2011

Knockout rats via embryo microinjection of zinc-finger nucleases

artículo científico publicado en 2009

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells

scientific article published on 11 January 2017

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

artículo científico publicado en 2016

Mammalian interspecies substitution of immune modulatory alleles by genome editing

artículo científico publicado en 2016

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

artículo científico publicado en 2014

Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

artículo científico publicado en 2016

Novel approaches to controlling transcription.

artículo científico publicado en 2002

PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis

artículo científico publicado en 2002

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

artículo científico publicado en 2009

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells ⬇️

artículo científico publicado el 6 de febrero de 2011

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors

artículo científico publicado en 2003

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

artículo científico publicado en 2008

Targeted genome editing across species using ZFNs and TALENs

artículo científico publicado en 2011

Targeted transgene integration in plant cells using designed zinc finger nucleases

artículo científico publicado en 2009

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

artículo científico publicado en 2013

Translating dosage compensation to trisomy 21

artículo científico publicado en 2013

Lista de obras de Edward Rebar

A TALE nuclease architecture for efficient genome editing

A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

A rapid and general assay for monitoring endogenous gene modification

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease

An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice.

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

An improved zinc-finger nuclease architecture for highly specific genome editing

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics

Designed transcription factors as tools for therapeutics and functional genomics

Development of pro-angiogenic engineered transcription factors for the treatment of cardiovascular disease

Diversifying the structure of zinc finger nucleases for high-precision genome editing

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. ⬇️

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

Enhancing gene editing specificity by attenuating DNA cleavage kinetics

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

Functional footprinting of regulatory DNA.

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application

Genetic engineering of human pluripotent cells using TALE nucleases

Genome editing with engineered zinc finger nucleases

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Knockout rats via embryo microinjection of zinc-finger nucleases

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Mammalian interspecies substitution of immune modulatory alleles by genome editing

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

Novel approaches to controlling transcription.

PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells ⬇️

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

Targeted genome editing across species using ZFNs and TALENs

Targeted transgene integration in plant cells using designed zinc finger nucleases

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Translating dosage compensation to trisomy 21