Lista de obras - Lokesh Gakhar - Dominio Público Uruguay

Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

artículo científico publicado en 2017

CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

artículo científico publicado en 2015

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

artículo científico publicado en 2011

Crystal structure of a complex of NOD1 CARD and ubiquitin

artículo científico publicado en 2014

Crystallization and preliminary X-ray diffraction analysis of naphthalene dioxygenase from Rhodococcus sp. strain NCIMB 12038.

artículo científico publicado en 2002

Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism. ⬇️

artículo científico publicado en 2012

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions

artículo científico publicado en 2016

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

artículo científico publicado en 2009

Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.

artículo científico publicado en 2015

Free energy simulations of active-site mutants of dihydrofolate reductase

artículo científico publicado en 2015

Functional characterization of a cancer causing mutation in human replication protein A

artículo científico publicado en 2010

High-resolution structure of the Tiam1 PHn-CC-Ex domain

artículo científico publicado en 2013

Interaction of aryl hydrocarbon receptor-interacting protein-like 1 with the farnesyl moiety

artículo científico publicado en 2013

Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

scientific article published on 11 September 2019

Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles

artículo científico publicado en 2013

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

scientific article published on 25 October 2016

Novel, Highly Specific N -Demethylases Enable Bacteria To Live on Caffeine and Related Purine Alkaloids ⬇️

artículo científico publicado el 10 de febrero de 2012

Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin

artículo científico publicado en 2015

PLUNC is a novel airway surfactant protein with anti-biofilm activity

artículo científico publicado en 2010

PLUNC: a multifunctional surfactant of the airways

artículo científico publicado en 2011

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

artículo científico publicado en 2014

Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay

artículo científico publicado en 2011

Rieske business: structure-function of Rieske non-heme oxygenases.

artículo científico publicado en 2005

Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

artículo científico publicado en 2014

SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection

artículo científico publicado en 2013

Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.

artículo científico publicado en 2016

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

artículo científico publicado en 2011

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

artículo científico publicado en 2009

Structural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachment

artículo científico publicado en 2015

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

scientific article published on 12 July 2019

Structure and increased thermostability of Rhodococcus sp. naphthalene 1,2-dioxygenase.

artículo científico publicado en 2005

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation

artículo científico publicado en 2016

The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains

artículo científico publicado en 2007

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

artículo científico publicado en 2013

The solution structure of the transducin-α-uncoordinated 119 protein complex suggests occlusion of the Gβ₁γ₁-binding sites

artículo científico publicado en 2014

The structure of LsrB from Yersinia pestis complexed with autoinducer-2 ⬇️

artículo científico publicado el 29 de noviembre de 2011

Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.

artículo científico publicado en 2017

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

artículo científico publicado en 2010

Lista de obras de Lokesh Gakhar

Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

Crystal structure of a complex of NOD1 CARD and ubiquitin

Crystallization and preliminary X-ray diffraction analysis of naphthalene dioxygenase from Rhodococcus sp. strain NCIMB 12038.

Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism. ⬇️

Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.

Free energy simulations of active-site mutants of dihydrofolate reductase

Functional characterization of a cancer causing mutation in human replication protein A

High-resolution structure of the Tiam1 PHn-CC-Ex domain

Interaction of aryl hydrocarbon receptor-interacting protein-like 1 with the farnesyl moiety

Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles

Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment

Novel, Highly Specific N -Demethylases Enable Bacteria To Live on Caffeine and Related Purine Alkaloids ⬇️

Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin

PLUNC is a novel airway surfactant protein with anti-biofilm activity

PLUNC: a multifunctional surfactant of the airways

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay

Rieske business: structure-function of Rieske non-heme oxygenases.

Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection

Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

Structural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachment

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

Structure and increased thermostability of Rhodococcus sp. naphthalene 1,2-dioxygenase.

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation

The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous Domains

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

The solution structure of the transducin-α-uncoordinated 119 protein complex suggests occlusion of the Gβ₁γ₁-binding sites

The structure of LsrB from Yersinia pestis complexed with autoinducer-2 ⬇️

Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins