Lista de obras - Peter J Lenting - Dominio Público Uruguay

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation-Brief Report.

artículo científico publicado en 2017

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

artículo científico publicado en 2018

A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation.

artículo científico publicado en 2016

A hemophilia A mouse model for the in vivo assessment of Emicizumab function

scientific article published on 05 May 2020

A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor

artículo científico publicado en 2012

A novel ELISA-based diagnosis of acquired von Willebrand disease with increased VWF proteolysis.

artículo científico publicado en 2016

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.

artículo científico publicado en 2009

A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B.

artículo científico publicado en 2005

ADAMTS-13: double trouble for von Willebrand factor

artículo científico publicado en 2010

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

artículo científico publicado en 2013

Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction

artículo científico publicado en 2010

Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa

scientific article published on 16 May 2008

An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation.

artículo científico publicado en 2003

Antibody-Based Protection of von Willebrand Factor Degradation

artículo científico publicado en 2016

Antibody-based prevention of von Willebrand factor degradation mediated by circulatory assist devices.

artículo científico publicado en 2014

Apoptotic Platelet Events Are Not Observed in Severe von Willebrand Disease-Type 2B Mutation p.V1316M.

artículo científico publicado en 2015

Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension.

artículo científico publicado en 2008

Author Correction: Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins

scientific article published on 13 August 2020

Beta2-glycoprotein I and LDL-receptor family members.

artículo científico publicado en 2004

Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK.

artículo científico publicado en 2004

Blood Coagulation Factor IX Residues Glu78 and Arg94 Provide a Link between Both Epidermal Growth Factor-like Domains That Is Crucial in the Interaction with Factor VIII Light Chain ⬇️

artículo científico publicado el 2 de enero de 1998

Camelid-derived single-chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

artículo científico publicado en 2020

Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein

artículo científico publicado en 2008

Characterization of the interaction between von Willebrand factor and osteoprotegerin

artículo científico publicado en 2007

Circulatory support devices: fundamental aspects and clinical management of bleeding and thrombosis.

artículo científico

Clearance of amyloid-beta by circulating lipoprotein receptors

artículo científico publicado en 2007

Clearance of von Willebrand factor

artículo científico publicado en 2008

Clearance of von Willebrand factor.

artículo científico

Cleavage of von Willebrand Factor by Granzyme M Destroys Its Factor VIII Binding Capacity ⬇️

artículo científico publicado el 1 de enero de 2011

Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients

artículo científico publicado en 2008

Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts

artículo científico publicado en 2010

Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance

artículo científico publicado en 2012

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

artículo científico publicado en 2006

Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.

artículo científico publicado en 2008

Correction of the bleeding time in von Willebrand factor (VWF)-deficient mice using murine VWF

scientific article published on 01 March 2007

Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients

artículo científico publicado en 2011

Depletion of CD4+/CD25high regulatory T cells may enhance or uncover factor VIII-specific T-cell responses in healthy individuals

artículo científico publicado en 2006

Diagnostic workup of patients with acquired von Willebrand syndrome: a retrospective single-centre cohort study

artículo científico publicado en 2008

Differential platelet adhesion to distinct life-cycle stages of the parasitic helminth Schistosoma mansoni

artículo científico publicado en 2007

Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'

artículo científico publicado en 2003

Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member

artículo científico publicado en 2010

Electron crystallography of human blood coagulation factor VIII bound to phospholipid monolayers

scientific article published on 01 December 1999

Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency

scientific article published on 09 January 2003

Emerging Therapeutic Strategies in the Treatment of Hemophilia A.

artículo científico publicado en 2017

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

artículo científico publicado en 2017

Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins

artículo científico publicado en 2020

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.

artículo científico publicado en 2014

Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5.

artículo científico publicado en 2012

Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII.

artículo científico publicado en 2007

Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B.

artículo científico publicado en 2001

Hydrophobic contact between the two epidermal growth factor-like domains of blood coagulation factor IX contributes to enzymatic activity

artículo científico publicado en 2000

Identification of Galectin-1 and Galectin-3 as Novel Partners for Von Willebrand Factor

artículo científico publicado en 2012

In vivo analysis of the role of O-glycosylations of von Willebrand factor.

artículo científico publicado en 2012

In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.

artículo científico publicado en 2005

Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice.

artículo científico publicado en 2005

Interaction between factor VIII and LDL receptor-related protein. Modulation of coagulation?

artículo científico publicado en 2000

Interaction of beta2-glycoprotein I with members of the low density lipoprotein receptor family.

artículo científico publicado en 2006

Kinetics of factor VIII light-chain cleavage by thrombin and factor Xa. A regulatory role of the factor VIII heavy-chain region Lys713-Arg740

artículo científico publicado en 1996

LDL receptor-related protein 1 contributes to the clearance of the activated factor VII-antithrombin complex.

artículo científico publicado en 2016

LDL-receptor-related protein regulates beta2-integrin-mediated leukocyte adhesion

artículo científico publicado en 2004

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.

artículo científico publicado en 2016

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

artículo científico publicado en 2004

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.

artículo científico publicado en 2016

Macrophage LRP1 contributes to the clearance of von Willebrand factor.

artículo científico publicado en 2012

Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X.

artículo científico publicado en 2015

Macrophage scavenger-receptor SR-AI contributes to the clearance of von Willebrand factor

artículo científico publicado en 2018

Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo.

artículo científico publicado en 2008

Mapping the collagen-binding site in the von Willebrand factor-A3 domain

artículo científico publicado en 2003

Models for prediction of factor VIII half-life in severe haemophiliacs: distinct approaches for blood group O and non-O patients

artículo científico publicado en 2009

Mouse leukocyte-associated Ig-like receptor-1 (mLAIR-1) functions as an inhibitory collagen-binding receptor on immune cells

artículo científico publicado en 2007

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.

artículo científico publicado en 2010

Mutations in the A3 domain of von Willebrand factor inducing combined qualitative and quantitative defects in the protein.

artículo científico publicado en 2013

New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets

artículo científico publicado en 2010

Of von Willebrand factor and platelets

artículo científico publicado en 2015

P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor

scientific article published on 22 August 2006

Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A

artículo científico publicado en 2007

Platelet von Willebrand factor: sweet resistance.

artículo científico publicado en 2013

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi

artículo científico publicado en 2017

Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets

artículo científico publicado en 2018

Regions 301-303 and 333-339 in the catalytic domain of blood coagulation factor IX are factor VIII-interactive sites involved in stimulation of enzyme activity.

artículo científico publicado en 1999

Regulation of von Willebrand factor-platelet interactions

artículo científico publicado en 2010

Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein

artículo científico publicado en 2003

Restoration of plasma von Willebrand factor deficiency is sufficient to correct thrombus formation after gene therapy for severe von Willebrand disease

artículo científico publicado en 2008

SHEARiO, fast lane to oxidized VWF ⬇️

artículo científico publicado el 10 de noviembre de 2011

Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance.

artículo científico publicado en 2015

Single-domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors

scientific article published on 11 March 2020

Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity

artículo científico publicado en 2016

Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.

artículo científico publicado en 2007

Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions

artículo científico publicado en 2006

The Light Chain of Factor VIII Comprises a Binding Site for Low Density Lipoprotein Receptor-related Protein

artículo científico publicado en 1999

The active conformation of von Willebrand factor in patients with thrombotic thrombocytopenic purpura in remission.

artículo científico publicado en 2009

The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain

scientific article published on 29 March 2002

The disappearing act of factor VIII.

artículo científico publicado en 2008

The presence of active von Willebrand factor under various pathological conditions

artículo científico publicado en 2007

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma.

artículo científico publicado en 2011

The von Willebrand factor self-association is modulated by a multiple domain interaction

artículo científico publicado en 2005

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

artículo científico publicado en 2013

Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria

artículo científico publicado en 2007

Towards standardization of in vivo thrombosis studies in mice.

artículo científico publicado en 2011

Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

artículo científico publicado en 2017

VWF clearance: it’s glycomplicated

artículo científico publicado en 2018

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors.

artículo científico publicado en 2006

Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels.

artículo científico publicado en 2006

Von Willebrand Factor Multimers during Transcatheter Aortic-Valve Replacement

artículo científico publicado en 2016

Von Willebrand factor C1C2 domain is involved in platelet adhesion to polymerized fibrin at high shear rate

artículo científico publicado en 2003

beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation

artículo científico publicado en 2007

von Willebrand Factor for Aortic Valve Intervention: From Bench to Real-Time Bedside Assessment

artículo científico publicado en 2018

von Willebrand factor A1 domain: stuck in the middle

scientific article published on 07 April 2007

von Willebrand factor activation, granzyme-B and thrombocytopenia in meningococcal disease.

artículo científico publicado en 2010

von Willebrand factor and inflammation

artículo científico publicado en 2017

von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends

artículo científico publicado en 2015

von Willebrand factor clearance does not involve proteolysis by ADAMTS-13

scientific article published on 01 October 2010

von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3.

artículo científico publicado en 2013

von Willebrand factor propeptide and the occurrence of a first ischemic stroke.

artículo científico publicado en 2010

von Willebrand factor: at the crossroads of bleeding and thrombosis.

artículo científico publicado en 2012

von Willebrand factor: the old, the new and the unknown.

artículo científico

Lista de obras de Peter J Lenting

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation-Brief Report.

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation.

A hemophilia A mouse model for the in vivo assessment of Emicizumab function

A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor

A novel ELISA-based diagnosis of acquired von Willebrand disease with increased VWF proteolysis.

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.

A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B.

ADAMTS-13: double trouble for von Willebrand factor

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction

Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa

An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation.

Antibody-Based Protection of von Willebrand Factor Degradation

Antibody-based prevention of von Willebrand factor degradation mediated by circulatory assist devices.

Apoptotic Platelet Events Are Not Observed in Severe von Willebrand Disease-Type 2B Mutation p.V1316M.

Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension.

Author Correction: Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins

Beta2-glycoprotein I and LDL-receptor family members.

Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK.

Blood Coagulation Factor IX Residues Glu78 and Arg94 Provide a Link between Both Epidermal Growth Factor-like Domains That Is Crucial in the Interaction with Factor VIII Light Chain ⬇️

Camelid-derived single-chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein

Characterization of the interaction between von Willebrand factor and osteoprotegerin

Circulatory support devices: fundamental aspects and clinical management of bleeding and thrombosis.

Clearance of amyloid-beta by circulating lipoprotein receptors

Clearance of von Willebrand factor

Clearance of von Willebrand factor.

Cleavage of von Willebrand Factor by Granzyme M Destroys Its Factor VIII Binding Capacity ⬇️

Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients

Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts

Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.

Correction of the bleeding time in von Willebrand factor (VWF)-deficient mice using murine VWF

Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients

Depletion of CD4+/CD25high regulatory T cells may enhance or uncover factor VIII-specific T-cell responses in healthy individuals

Diagnostic workup of patients with acquired von Willebrand syndrome: a retrospective single-centre cohort study

Differential platelet adhesion to distinct life-cycle stages of the parasitic helminth Schistosoma mansoni

Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'

Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member

Electron crystallography of human blood coagulation factor VIII bound to phospholipid monolayers

Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency

Emerging Therapeutic Strategies in the Treatment of Hemophilia A.

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.

Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5.

Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII.

Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B.

Hydrophobic contact between the two epidermal growth factor-like domains of blood coagulation factor IX contributes to enzymatic activity

Identification of Galectin-1 and Galectin-3 as Novel Partners for Von Willebrand Factor

In vivo analysis of the role of O-glycosylations of von Willebrand factor.

In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.

Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice.

Interaction between factor VIII and LDL receptor-related protein. Modulation of coagulation?

Interaction of beta2-glycoprotein I with members of the low density lipoprotein receptor family.

Kinetics of factor VIII light-chain cleavage by thrombin and factor Xa. A regulatory role of the factor VIII heavy-chain region Lys713-Arg740

LDL receptor-related protein 1 contributes to the clearance of the activated factor VII-antithrombin complex.

LDL-receptor-related protein regulates beta2-integrin-mediated leukocyte adhesion

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.

Macrophage LRP1 contributes to the clearance of von Willebrand factor.

Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X.

Macrophage scavenger-receptor SR-AI contributes to the clearance of von Willebrand factor

Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo.

Mapping the collagen-binding site in the von Willebrand factor-A3 domain

Models for prediction of factor VIII half-life in severe haemophiliacs: distinct approaches for blood group O and non-O patients

Mouse leukocyte-associated Ig-like receptor-1 (mLAIR-1) functions as an inhibitory collagen-binding receptor on immune cells

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.

Mutations in the A3 domain of von Willebrand factor inducing combined qualitative and quantitative defects in the protein.

New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets

Of von Willebrand factor and platelets

P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor

Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A

Platelet von Willebrand factor: sweet resistance.

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi

Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets