Lista de obras - Hin Chu - Dominio Público Uruguay

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

artículo científico publicado en 2020

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

artículo científico publicado en 2020

A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.

artículo científico publicado en 2015

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.

artículo científico publicado en 2016

A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.

artículo científico publicado en 2016

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.

artículo científico publicado en 2016

A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions

artículo científico publicado en 2015

Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages

artículo científico publicado en 2020

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis

artículo científico publicado en 2013

Air and environmental sampling for SARS-CoV-2 around hospitalized patients with coronavirus disease 2019 (COVID-19)

artículo científico publicado en 2020

Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus.

artículo científico publicado en 2016

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

artículo científico publicado en 2022

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice

artículo científico publicado en 2017

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

scientific article published on 17 April 2020

Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes.

artículo científico publicado en 2017

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

artículo científico publicado en 2020

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

artículo científico publicado en 2016

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

artículo científico publicado en 2019

Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters

scientific article published on 07 October 2020

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

scientific article published on 09 April 2020

Cross-protection of influenza A virus infection by a DNA aptamer targeting the PA endonuclease domain.

artículo científico

Differentiated human airway organoids to assess infectivity of emerging influenza virus

article published in the Proceedings of the National Academy of Sciences of the United States of America

Discovery and high prevalence of Phasi Charoen-like virus in field-captured Aedes aegypti in South China

article

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza.

artículo científico publicado en 2018

Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids

artículo científico publicado en 2022

Establishment of a lethal aged mouse model of human respiratory syncytial virus infection

artículo científico publicado en 2018

Factors affecting stability and infectivity of SARS-CoV-2

scientific article published on 08 July 2020

Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).

artículo científico publicado en 2015

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

artículo científico publicado en 2020

H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses

scientific article published on 05 June 2019

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization

artículo científico publicado en 2016

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

artículo científico publicado en 2017

Identification and characterization of GLDC as host susceptibility gene to severe influenza

article

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.

artículo científico publicado en 2015

Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.

artículo científico publicado en 2016

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

artículo científico publicado en 2015

Infection of bat and human intestinal organoids by SARS-CoV-2

scientific article published on 13 May 2020

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

artículo científico publicado en 2022

Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.

artículo científico publicado en 2018

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells

scientific article published on 26 November 2019

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

artículo científico publicado en 2016

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

artículo científico publicado en 2020

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

artículo científico publicado en 2015

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

artículo científico publicado en 2018

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis

artículo científico publicado en 2015

Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern

artículo científico publicado en 2016

Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts

artículo científico publicado en 2016

PAN substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities.

artículo científico publicado en 2017

PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals

artículo científico publicado en 2016

PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs

artículo científico publicado en 2015

Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo.

artículo científico publicado en 2016

Phosphorylation of the nucleocapsid protein of Hantaan virus by casein kinase II.

artículo científico publicado en 2015

Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies.

artículo científico publicado en 2015

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.

artículo científico publicado en 2014

Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol

scientific article published on 01 February 2019

ROCK1 and LIM kinase modulate retrovirus particle release and cell-cell transmission events

artículo científico publicado en 2014

Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex ⬇️

artículo científico publicado el 4 de abril de 2013

Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine

artículo científico publicado en 2020

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

artículo científico publicado en 2022

SARS-CoV-2 infects human neural progenitor cells and brain organoids

scientific article published on 04 August 2020

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

scientific article published on 12 June 2020

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

artículo científico publicado en 2019

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

artículo científico publicado en 2019

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

scientific article published on 26 March 2020

Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19)

artículo científico publicado en 2020

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

scientific article published on 17 January 2019

Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.

artículo científico publicado en 2012

The Intracellular Virus-Containing Compartments in Primary Human Macrophages Are Largely Inaccessible to Antibodies and Small Molecules ⬇️

artículo científico publicado el 2 de mayo de 2012

The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle release

artículo científico publicado en 2011

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

artículo científico publicado en 2015

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

scientific article published on 28 August 2020

Lista de obras de Hin Chu

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.

A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.

A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions

Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis

Air and environmental sampling for SARS-CoV-2 around hospitalized patients with coronavirus disease 2019 (COVID-19)

Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus.

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes.

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

Cross-protection of influenza A virus infection by a DNA aptamer targeting the PA endonuclease domain.

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Discovery and high prevalence of Phasi Charoen-like virus in field-captured Aedes aegypti in South China

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza.

Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids

Establishment of a lethal aged mouse model of human respiratory syncytial virus infection

Factors affecting stability and infectivity of SARS-CoV-2

Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Identification and characterization of GLDC as host susceptibility gene to severe influenza

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.

Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

Infection of bat and human intestinal organoids by SARS-CoV-2

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis

Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern

Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts

PAN substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities.

PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals

PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs

Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo.

Phosphorylation of the nucleocapsid protein of Hantaan virus by casein kinase II.

Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies.

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.

Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol

ROCK1 and LIM kinase modulate retrovirus particle release and cell-cell transmission events

Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex ⬇️

Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

SARS-CoV-2 infects human neural progenitor cells and brain organoids

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19)

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.

The Intracellular Virus-Containing Compartments in Primary Human Macrophages Are Largely Inaccessible to Antibodies and Small Molecules ⬇️

The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle release

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target