Lista de obras - Francisco Gamarro - Dominio Público Uruguay

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

artículo científico publicado en 2014

A new ABC half-transporter in Leishmania major is involved in resistance to antimony.

artículo científico publicado en 2013

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania

artículo científico publicado en 2011

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter.

artículo científico publicado en 1998

A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids

artículo científico publicado en 2007

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

artículo científico publicado en 1997

ABC transporters in the protozoan parasite Leishmania.

artículo científico publicado en 2001

ABCI3 Is a New Mitochondrial ABC Transporter from Leishmania major Involved in Susceptibility to Antimonials and Infectivity

artículo científico publicado en 2017

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

artículo científico publicado en 2001

All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae

artículo científico publicado en 2008

Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

artículo científico publicado en 1998

Amplification of the H locus in Leishmania infantum.

artículo científico publicado en 1994

Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine.

artículo científico publicado en 2011

Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine

artículo científico publicado en 2010

Arylthiosemicarbazones as antileishmanial agents

artículo científico publicado en 2016

Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance

artículo científico publicado en 2007

Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.

artículo científico publicado en 2008

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells

artículo científico publicado en 2010

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

artículo científico publicado en 2004

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).

artículo científico publicado en 2003

Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.

artículo científico publicado en 1999

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.

artículo científico publicado en 2004

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

artículo científico publicado en 2008

Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis

artículo científico publicado en 2001

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux

artículo científico publicado en 2006

Correction: LABCG2, a New ABC Transporter Implicated in Phosphatidylserine Exposure, Is Involved in the Infectivity and Pathogenicity of Leishmania.

artículo científico publicado en 2013

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.

artículo científico publicado en 2016

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

artículo científico publicado en 2014

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

artículo científico publicado en 2005

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

artículo científico publicado en 2008

Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion

artículo científico publicado en 2010

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.

artículo científico publicado en 2017

Effect of interferon on the infectivity of Trypanosoma cruzi in cultured heLa cells

artículo científico publicado en 1985

Effect of poly-l-lysine and neuraminidase on the infectivity of Trypanosoma cruzi in cultured HeLa cells

artículo científico publicado en 1985

Effet des enzymes protéolytiques sur la pénétration duTrypanosoma cruzidans les macrophages péritonéaux de souris

Evolutionary relationships in Trypanosoma cruzi: molecular phylogenetics supports the existence of a new major lineage of strains

artículo científico publicado en 2000

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.

artículo científico publicado en 2015

Fitness of Leishmania donovani parasites resistant to drug combinations

artículo científico publicado en 2015

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

artículo científico publicado en 2005

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

artículo científico publicado en 2003

Functional expression of a multidrug P-glycoprotein transporter of Leishmania

artículo científico publicado en 2005

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit

artículo científico publicado en 2014

Functional role of highly-conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase.

artículo científico publicado en 2018

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

artículo científico publicado en 2016

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

artículo científico publicado en 2001

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

artículo científico publicado en 2014

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

artículo científico publicado en 2013

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

artículo científico publicado en 2007

Increased P-Type ATPase Activity in Leishmania tropica Resistant to Methotrexate

artículo científico publicado en 1994

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major

artículo científico publicado en 2011

Inhibition of lysosomal fusion by Trypanosoma cruzi in peritoneal macrophages

artículo científico publicado en 1986

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.

artículo científico publicado en 2006

Involvement of thiol metabolism in resistance to glucantime in leishmania tropica ⬇️

artículo científico publicado el 1 de noviembre de 1998

Isolation and purification of amastigotes of Trypanosoma cruzi from cultured Vero cells

artículo científico publicado en 1985

LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania

artículo científico publicado en 2013

Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy.

artículo científico publicado en 2017

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols

artículo científico publicado en 2017

Leishmania donovani develops resistance to drug combinations

artículo científico publicado en 2012

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

artículo científico publicado en 2003

Leishmanicidal and Reversal Multidrug Resistance Constituents from Aeonium lindleyi

artículo científico publicado en 2010

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug

artículo científico publicado en 2009

Mechanisms of action of substituted β-amino alkanols on Leishmania donovani.

artículo científico publicado en 2014

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

artículo científico publicado en 2006

Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi.

artículo científico publicado en 1996

New Antiparasitic Agents

artículo científico publicado en 1988

New Natural Sesquiterpenes as Modulators of Daunomycin Resistance in a Multidrug-ResistantLeishmaniatropicaLine‖,⊥

artículo científico publicado en 1999

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

artículo científico publicado en 2007

Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry

artículo científico publicado en 2010

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

artículo científico

Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance

artículo científico publicado en 2009

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.

artículo científico publicado en 2016

Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes

artículo científico publicado en 2011

Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania

scientific article published on 10 August 2012

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

artículo científico publicado en 2006

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity

artículo científico publicado en 2001

Purification of a glycoprotein excreted by Trypanosomacruzi to increase the permeability of the host-cell membrane

scientific article published on 01 January 1990

Purification of metacyclic forms of Trypanosoma cruzi by Percoll discontinuous gradient centrifugation

artículo científico publicado en 1984

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

artículo científico publicado en 2003

Rapid transport of phospholipids across the plasma membrane of Leishmania infantum

artículo científico publicado en 2003

Resistance to reinfection of HeLa cells parasitized by Trypanosoma cruzi

artículo científico publicado en 1984

Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola

artículo científico publicado en 2015

Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis

artículo científico publicado en 2005

SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.

artículo científico publicado en 2004

Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.

artículo científico publicado en 2011

Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

artículo científico publicado en 2008

Some factors affecting the in vitro invasion of HeLa cells by Trypanosoma cruzi

artículo científico publicado en 1984

Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis

artículo científico publicado en 2010

Terpenoids from Maytenus Species and Assessment of Their Reversal Activity against a Multidrug-Resistant Leishmania tropica Line ⬇️

scientific article published on 01 December 2011

The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase

artículo científico publicado en 2011

The Different Behavior of Diphtheria Toxin, Modeccin and Ricin in HeLa Cells Infected with Trypanosoma cruzi

artículo científico publicado en 1994

The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance.

artículo científico publicado en 2016

The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei

artículo científico publicado en 2015

The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.

artículo científico publicado en 2007

The invasion mechanism of the metacyclic forms of Trypanosoma cruzi in nonphagocytic host cells

artículo científico publicado el 1 de enero de 1993

The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.

artículo científico publicado en 2003

The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in Leishmania

artículo científico publicado en 2005

Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme.

artículo científico publicado en 1995

Trypanosoma cruzi: Calcium ion movement during internalization in host HeLa cells

scientific article published on 01 August 1990

Trypanosoma cruzi: Molecular Cloning of a Gene Coding for a Putative Vacuolar Protein

article

Trypanosoma cruzi: sequence of the ATP-binding site of a P-glycoprotein gene.

artículo científico

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi.

artículo científico publicado en 2002

Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents

artículo científico publicado en 2016

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania

artículo científico publicado en 2011

[Ultrastructural study of the effect of 2 derivatives benzo (de) isoquinoline-1,3-dione on Trypanosoma cruzi in vitro]

artículo científico publicado en 1983

Lista de obras de Francisco Gamarro

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

A new ABC half-transporter in Leishmania major is involved in resistance to antimony.

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter.

A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

ABC transporters in the protozoan parasite Leishmania.

ABCI3 Is a New Mitochondrial ABC Transporter from Leishmania major Involved in Susceptibility to Antimonials and Infectivity

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae

Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

Amplification of the H locus in Leishmania infantum.

Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine.

Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine

Arylthiosemicarbazones as antileishmanial agents

Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance

Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).

Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux

Correction: LABCG2, a New ABC Transporter Implicated in Phosphatidylserine Exposure, Is Involved in the Infectivity and Pathogenicity of Leishmania.

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.

Effect of interferon on the infectivity of Trypanosoma cruzi in cultured heLa cells

Effect of poly-l-lysine and neuraminidase on the infectivity of Trypanosoma cruzi in cultured HeLa cells

Effet des enzymes protéolytiques sur la pénétration duTrypanosoma cruzidans les macrophages péritonéaux de souris

Evolutionary relationships in Trypanosoma cruzi: molecular phylogenetics supports the existence of a new major lineage of strains

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.

Fitness of Leishmania donovani parasites resistant to drug combinations

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

Functional expression of a multidrug P-glycoprotein transporter of Leishmania

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit

Functional role of highly-conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase.

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

Increased P-Type ATPase Activity in Leishmania tropica Resistant to Methotrexate

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major

Inhibition of lysosomal fusion by Trypanosoma cruzi in peritoneal macrophages

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.

Involvement of thiol metabolism in resistance to glucantime in leishmania tropica ⬇️

Isolation and purification of amastigotes of Trypanosoma cruzi from cultured Vero cells

LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania

Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy.

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols

Leishmania donovani develops resistance to drug combinations

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

Leishmanicidal and Reversal Multidrug Resistance Constituents from Aeonium lindleyi

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug

Mechanisms of action of substituted β-amino alkanols on Leishmania donovani.

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi.

New Antiparasitic Agents

New Natural Sesquiterpenes as Modulators of Daunomycin Resistance in a Multidrug-ResistantLeishmaniatropicaLine‖,⊥

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.

Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes

Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity

Purification of a glycoprotein excreted by Trypanosomacruzi to increase the permeability of the host-cell membrane

Purification of metacyclic forms of Trypanosoma cruzi by Percoll discontinuous gradient centrifugation

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

Rapid transport of phospholipids across the plasma membrane of Leishmania infantum