Filtros de búsqueda

Lista de obras de Albena T Dinkova-Kostova

(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase ⬇️

artículo científico publicado en 1996

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

artículo científico publicado en 2018

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

artículo científico publicado en 2008

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

artículo científico publicado en 2008

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

artículo científico publicado en 2017

Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

artículo científico publicado en 2017

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones

artículo científico publicado en 2010

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

artículo científico publicado en 2020

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

artículo científico publicado en 2010

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

artículo científico publicado en 2020

Assessment of ROS Production in the Mitochondria of Live Cells

artículo científico publicado en 2021

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

artículo científico publicado en 2018

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

artículo científico publicado en 2020

Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway

artículo científico publicado en 2006

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

artículo científico publicado en 2019

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.

artículo científico publicado en 2018

Can Activation of NRF2 Be a Strategy against COVID-19?

artículo científico publicado en 2020

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

scientific article published on 14 August 2010

Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity.

artículo científico publicado en 2008

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

artículo científico publicado en 2012

Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders

artículo científico publicado en 2010

Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

artículo científico publicado en 2004

Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids

artículo científico publicado en 2014

Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms ⬇️

artículo científico publicado el 1 de enero de 2013

Chemoprotection against cancer: an idea whose time has come

artículo científico publicado en 2007

Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers

artículo científico publicado en 1998

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

artículo científico publicado en 2005

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

artículo científico publicado en 2021

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

artículo científico publicado en 2008

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

artículo científico publicado en 2009

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses.

artículo científico publicado en 2017

Curcumin and the cellular stress response in free radical-related diseases.

artículo científico publicado en 2008

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction

artículo científico publicado en 2015

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

artículo científico publicado en 2010

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

artículo científico publicado en 2013

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

artículo científico publicado en 2008

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

artículo científico publicado en 2002

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

scientific article published on 06 October 2020

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

artículo científico

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

artículo científico publicado en 2016

Electrophilic tuning of the chemoprotective natural product sulforaphane.

artículo científico publicado en 2010

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions.

artículo científico publicado en 2017

Erratum to “Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans” [Clin. Chim. Acta 316 (2002) 43–53]

scholarly article published in Clinica Chimica Acta

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

artículo científico publicado en 2017

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

artículo científico publicado en 2005

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

artículo científico publicado en 2016

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.

artículo científico publicado en 2017

Glucosinolates and isothiocyanates in health and disease.

artículo científico publicado en 2012

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

artículo científico publicado en 2012

HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway

artículo científico publicado en 2011

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

artículo científico publicado en 2016

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

artículo científico publicado en 2020

Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy

artículo científico publicado en 2012

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

artículo científico publicado en 2003

Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols

artículo científico publicado en 2010

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

artículo científico publicado en 2007

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

artículo científico publicado en 2019

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

scientific article published on 22 August 2020

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

artículo científico publicado en 2018

KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane

artículo científico publicado en 2017

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

artículo científico publicado en 2018

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

artículo científico publicado en 2020

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

artículo científico publicado en 2017

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.

artículo científico publicado en 2016

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

artículo científico publicado en 2005

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

artículo científico publicado en 2016

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

artículo científico publicado en 2009

Measuring Changes in Keap1-Nrf2 Protein Complex Conformation in Individual Cells by FLIM-FRET

artículo científico publicado en 2020

Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

scientific article published on 11 March 2019

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

artículo científico publicado en 2015

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

artículo científico publicado en 2017

Monitoring Keap1-Nrf2 interactions in single live cells

artículo científico

NAD(P)H : quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

artículo científico publicado en 2013

NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

artículo científico publicado en 2016

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

artículo científico publicado en 2010

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

artículo científico publicado en 2016

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

artículo científico publicado en 2020

NRF2 as an Emerging Therapeutic Target.

artículo científico publicado en 2017

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis

artículo científico publicado en 2022

Natural antioxidants in Alzheimer's disease

artículo científico publicado en 2007

Neuroprotective effects of sulforaphane after contusive spinal cord injury.

artículo científico publicado en 2012

New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase

artículo científico publicado en 2015

Nitric oxide in cell survival: a janus molecule

artículo científico publicado en 2009

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

artículo científico publicado en 2007

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

artículo científico publicado en 2015

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

artículo científico publicado en 2016

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

scientific article published on 30 January 2022

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

artículo científico publicado en 2014

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

artículo científico publicado en 2013

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

scientific article published on 09 December 2020

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

artículo científico publicado en 2014

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

artículo científico publicado en 2016

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

scientific article published on 20 March 2020

Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

artículo científico publicado en 2017

Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.

artículo científico publicado en 2011

Oxidative Stress in Cancer

artículo científico publicado en 2020

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

artículo científico publicado en 2017

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

artículo científico publicado en 2017

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.

artículo científico publicado en 2017

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

artículo científico publicado en 2000

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.

artículo científico publicado en 2015

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1

artículo científico publicado en 2018

Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants.

artículo científico publicado en 2007

Phenolics in Aging and Neurodegenerative Disorders

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode

scientific article published on 12 May 2022

Phylogenetic Links in Plant Defense Systems: Lignans, Isoflavonoids, and Their Reductases

article

Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms

artículo científico publicado en 2008

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

artículo científico publicado en 2001

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1.

artículo científico publicado en 2016

Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index

artículo científico publicado en 2010

Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane

artículo científico publicado en 2001

Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state

artículo científico publicado en 2008

Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors

artículo científico publicado en 2009

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

artículo científico publicado en 2007

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

artículo científico publicado en 2005

Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes

artículo científico publicado en 2002

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

artículo científico publicado en 2004

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

artículo científico publicado en 2004

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

artículo científico publicado en 2002

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

artículo científico publicado en 2020

Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

scientific article published on August 2008

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

artículo científico publicado en 2004

Regiochemical control of monolignol radical coupling: a new paradigm for lignin and lignan biosynthesis.

artículo científico publicado en 1999

Regulation of the mammalian heat shock factor 1.

artículo científico publicado en 2017

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

artículo científico publicado en 2013

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

scientific article published on 01 May 1999

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

artículo científico publicado en 2007

Rhodiola rosea L.: from golden root to green cell factories

Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates

artículo científico publicado en 2004

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

artículo científico publicado en 2016

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

artículo científico publicado en 2006

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

artículo científico publicado en 2016

Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia.

artículo científico publicado en 1993

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

artículo científico publicado en 2007

Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

artículo científico publicado en 2020

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation.

artículo científico publicado en 2013

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w ⬇️

scholarly article by Paul Meakin published in September 2014

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent.

artículo científico publicado en 2011

Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of it

artículo científico publicado en 2013

Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1.

artículo científico publicado en 2016

Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.

artículo científico publicado en 2014

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

artículo científico publicado en 2012

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

artículo científico publicado en 2016

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.

artículo científico publicado en 2014

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

artículo científico publicado en 2018

The "Prochaska" microtiter plate bioassay for inducers of NQO1.

artículo científico publicado en 2004

The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis

artículo científico publicado en 2021

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

artículo científico publicado en 2023

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

artículo científico publicado en 2014

The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response

artículo científico publicado en 2012

The cytoprotective role of the Keap1-Nrf2 pathway

scientific article published on 02 March 2011

The emerging role of Nrf2 in mitochondrial function

artículo científico

The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

artículo científico publicado en 2012

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

artículo científico publicado en 2019

The multifaceted role of Nrf2 in mitochondrial function

The role of Keap1 in cellular protective responses

artículo científico publicado en 2005

The role of Nrf2 signaling in counteracting neurodegenerative diseases

artículo científico publicado en 2018

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

artículo científico publicado en 2015

The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

artículo científico publicado en 2020

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

artículo científico publicado en 2019

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection.

artículo científico publicado en 2014

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

artículo científico publicado en 2017

Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

artículo científico publicado en 2008

Vitagenes, cellular stress response, and acetylcarnitine: relevance to hormesis

artículo científico publicado en 2009

Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases.

artículo científico publicado en 2009

Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma

artículo científico publicado en 2016

Guía para el uso y la interpretación de ensayos para el seguimiento de la autofagia (4ª edición)

artículo científico

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda