Lista de obras - Robert H Cichewicz - Dominio Público Uruguay

A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.

artículo científico publicado en 2008

A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. ⬇️

artículo científico publicado en 2014

A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity

artículo científico publicado en 2010

An Electrophilic Natural Product Provides a Safe and Robust Odor Neutralization Approach To Counteract Malodorous Organosulfur Metabolites Encountered in Skunk Spray

artículo científico publicado en 2019

An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures

artículo científico publicado en 2020

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines

artículo científico publicado en 2019

Assessing Microbial Metabolic and Biological Diversity to Inform Natural Product Library Assembly

artículo científico publicado en 2022

Bioactive sulfur-containing sulochrin dimers and other metabolites from an Alternaria sp. isolate from a Hawaiian soil sample ⬇️

artículo científico publicado en 2014

Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity

artículo científico publicado en 2007

Briarane Diterpenes DiminishCOX-2Expression in Human Colon Adenocarcinoma Cells

artículo científico publicado en 2011

Bringing natural products into the fold - exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases

artículo científico publicado en 2010

Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies

artículo científico publicado en 2021

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

artículo científico publicado en 2020

Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum ⬇️

artículo científico publicado en 2010

Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger.

artículo científico publicado en 2009

Chemoenzymatic synthesis of daptomycin analogs active against daptomycin-resistant strains

scientific article published on 28 July 2020

Chemoreactive Natural Products that Afford Resistance Against Disparate Antibiotics and Toxins ⬇️

artículo científico publicado en 2016

Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid ⬇️

artículo científico publicado en 2014

Cholinesterase Inhibitory Arisugacins L-Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay

scientific article published on 21 August 2019

Correction to Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-Anthropoidal Mammalian Microbiomes

artículo científico publicado en 2017

Corrigendum: Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity.

artículo científico publicado en 2015

Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity ⬇️

artículo científico publicado en 2013

Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits

artículo científico publicado en 2003

Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum

artículo científico publicado en 2014

Design and Application of a High-Throughput, High-Content Screening System for Natural Product Inhibitors of the Human Parasite Trichomonas vaginalis

scientific article published on 02 July 2019

Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach ⬇️

artículo científico publicado en 2012

Diterpenes from the endangered goldenrod Solidago shortii

artículo científico publicado en 2014

Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

artículo científico publicado en 2016

Epigenetic remodeling of the fungal secondary metabolome

artículo científico publicado en 2008

Erratum to “Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves” [Life Sciences 75 (2004) 753–763]

artículo científico publicado en 2004

Fungal biofilm inhibitors from a human oral microbiome-derived bacterium.

artículo científico publicado en 2012

Genomic and metabolomic insights into the natural product biosynthetic diversity of a feral-hog-associated Brevibacillus laterosporus strain ⬇️

artículo científico publicado en 2014

Genomic island TnSmu2 of Streptococcus mutans harbors a nonribosomal peptide synthetase-polyketide synthase gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance.

artículo científico publicado en 2010

Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species. ⬇️

artículo científico publicado en 2017

Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers

artículo científico publicado en 2019

Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants

artículo científico publicado en 2015

Identification of Leucinostatins from <i>Ophiocordyceps</i> sp. as Antiparasitic Agents against <i>Trypanosoma cruzi</i>

artículo científico publicado en 2022

In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway

artículo científico publicado en 2019

Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies

artículo científico publicado en 2004

Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.

artículo científico publicado en 2008

Kwanzoquinones A–G and other constituents of Hemerocallis fulva ‘Kwanzo’ roots and their activity against the human pathogenic trematode Schistosoma mansoni

artículo científico publicado en 2003

Kwanzoquinones A—G and Other Constituents of Hemerocallis fulva “Kwanzo” Roots and Their Activity Against the Human Pathogenic Trematode Schistosoma mansoni.

Leucinostatins from Ophiocordyceps spp. and Purpureocillium spp. Demonstrate Selective Antiproliferative Effects in Cells Representing the Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer

artículo científico publicado en 2020

Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics

Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves

artículo científico publicado en 2004

Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer

scientific article published on 16 June 2016

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition ⬇️

artículo científico publicado en 2010

Natural-Product-Inspired Compounds as Countermeasures against the Liver Carcinogen Aflatoxin B1

scientific article published on 28 May 2019

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

artículo científico publicado en 2011

Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes.

artículo científico publicado en 2016

Osteoclast Differentiation is Downregulated by Select Polyphenolic Fractions from Dried Plum via Suppression of MAPKs and Nfatc1 in Mouse C57BL/6 Primary Bone Marrow Cells

scientific article published on 06 September 2017

Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.

artículo científico publicado en 2017

Phenylethanoid and lignan glycosides from polar extracts of Lantana, a genus of verbenaceous plants widely used in traditional herbal therapies

scientific article published on 01 July 2009

Polyketide glycosides from Bionectria ochroleuca inhibit Candida albicans biofilm formation ⬇️

artículo científico publicado en 2014

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase

artículo científico publicado en 2004

Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice

artículo científico publicado en 2010

Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets

artículo científico publicado en 2012

Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family

artículo científico publicado en 2004

Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems

artículo científico publicado en 2011

Reassessing the ichthyotoxin profile of cultured Prymnesium parvum (golden algae) and comparing it to samples collected from recent freshwater bloom and fish kill events in North America

artículo científico publicado en 2010

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

artículo científico publicado en 2004

Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea ⬇️

Secondary Metabolites from an Algicolous Aspergillus versicolor Strain ⬇️

artículo científico publicado el 16 de enero de 2012

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

scientific article published on 02 January 2019

Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring ⬇️

artículo científico publicado en 2012

Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer

artículo científico publicado en 2016

Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates.

artículo científico publicado en 2013

Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen

artículo científico publicado en 2016

Special Issue in Honor of Professor Phil Crews

artículo científico publicado en 2017

Spiro fused diterpene-indole alkaloids from a creek-bottom-derived Aspergillus terreus ⬇️

scientific article published on 07 August 2013

Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties

artículo científico publicado en 2007

Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods

artículo científico publicado en 2020

Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells

artículo científico publicado en 2017

Taccalonolide Microtubule Stabilizers Generated Using Semisynthesis Define the Effects of Mono Acyloxy Moieties at C-7 or C-15 and Disubstitutions at C-7 and C-25.

artículo científico publicado en 2018

Targeting mosquito FREP1 with a fungal metabolite blocks malaria transmission

artículo científico publicado en 2015

Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells.

artículo científico publicado en 2016

Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite Production

scientific article published on 10 June 2015

Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea

scientific article published on 10 July 2020

Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.

artículo científico publicado en 2017

Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris

artículo científico publicado en 2020

WITHDRAWN: A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity

artículo científico publicado en 2010

Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans ⬇️

artículo científico publicado en 2012

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data ⬇️

scientific article published in 2024

trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease

artículo científico publicado en 2012

Lista de obras de Robert H Cichewicz

A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.

A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. ⬇️

A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity

An Electrophilic Natural Product Provides a Safe and Robust Odor Neutralization Approach To Counteract Malodorous Organosulfur Metabolites Encountered in Skunk Spray

An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines

Assessing Microbial Metabolic and Biological Diversity to Inform Natural Product Library Assembly

Bioactive sulfur-containing sulochrin dimers and other metabolites from an Alternaria sp. isolate from a Hawaiian soil sample ⬇️

Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity

Briarane Diterpenes DiminishCOX-2Expression in Human Colon Adenocarcinoma Cells

Bringing natural products into the fold - exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases

Building Natural Product Libraries Using Quantitative Clade-Based and Chemical Clustering Strategies

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum ⬇️

Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger.

Chemoenzymatic synthesis of daptomycin analogs active against daptomycin-resistant strains

Chemoreactive Natural Products that Afford Resistance Against Disparate Antibiotics and Toxins ⬇️

Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid ⬇️

Cholinesterase Inhibitory Arisugacins L-Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay

Correction to Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-Anthropoidal Mammalian Microbiomes

Corrigendum: Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity.

Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity ⬇️

Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits

Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum

Design and Application of a High-Throughput, High-Content Screening System for Natural Product Inhibitors of the Human Parasite Trichomonas vaginalis

Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach ⬇️

Diterpenes from the endangered goldenrod Solidago shortii

Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

Epigenetic remodeling of the fungal secondary metabolome

Erratum to “Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves” [Life Sciences 75 (2004) 753–763]

Fungal biofilm inhibitors from a human oral microbiome-derived bacterium.

Genomic and metabolomic insights into the natural product biosynthetic diversity of a feral-hog-associated Brevibacillus laterosporus strain ⬇️

Genomic island TnSmu2 of Streptococcus mutans harbors a nonribosomal peptide synthetase-polyketide synthase gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance.

Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species. ⬇️

Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers

Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants

Identification of Leucinostatins from <i>Ophiocordyceps</i> sp. as Antiparasitic Agents against <i>Trypanosoma cruzi</i>

In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway

Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies

Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.

Kwanzoquinones A–G and other constituents of Hemerocallis fulva ‘Kwanzo’ roots and their activity against the human pathogenic trematode Schistosoma mansoni

Kwanzoquinones A—G and Other Constituents of Hemerocallis fulva “Kwanzo” Roots and Their Activity Against the Human Pathogenic Trematode Schistosoma mansoni.

Leucinostatins from Ophiocordyceps spp. and Purpureocillium spp. Demonstrate Selective Antiproliferative Effects in Cells Representing the Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer

Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics

Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves

Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition ⬇️

Natural-Product-Inspired Compounds as Countermeasures against the Liver Carcinogen Aflatoxin B1

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes.

Osteoclast Differentiation is Downregulated by Select Polyphenolic Fractions from Dried Plum via Suppression of MAPKs and Nfatc1 in Mouse C57BL/6 Primary Bone Marrow Cells

Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.

Phenylethanoid and lignan glycosides from polar extracts of Lantana, a genus of verbenaceous plants widely used in traditional herbal therapies

Polyketide glycosides from Bionectria ochroleuca inhibit Candida albicans biofilm formation ⬇️

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase

Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice

Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets

Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family

Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems

Reassessing the ichthyotoxin profile of cultured Prymnesium parvum (golden algae) and comparing it to samples collected from recent freshwater bloom and fish kill events in North America

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea ⬇️

Secondary Metabolites from an Algicolous Aspergillus versicolor Strain ⬇️

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring ⬇️

Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer

Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates.

Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen

Special Issue in Honor of Professor Phil Crews

Spiro fused diterpene-indole alkaloids from a creek-bottom-derived Aspergillus terreus ⬇️

Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties

Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods

Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells

Taccalonolide Microtubule Stabilizers Generated Using Semisynthesis Define the Effects of Mono Acyloxy Moieties at C-7 or C-15 and Disubstitutions at C-7 and C-25.

Targeting mosquito FREP1 with a fungal metabolite blocks malaria transmission

Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells.

Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite Production

Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea

Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.