Lista de obras - Nyssa Drinkwater - Dominio Público Uruguay

Circumventing the stability-function trade-off in an engineered FN3 domain

artículo científico publicado en 2016

Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

artículo científico publicado en 2006

Crystal structure of a β-aminopeptidase from an Australian Burkholderia sp.

artículo científico publicado en 2017

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

artículo científico publicado en 2010

From crystal to compound: structure-based antimalarial drug discovery

artículo científico publicado en 2014

Human immunoglobulin E flexes between acutely bent and extended conformations.

artículo científico publicado en 2014

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

artículo científico publicado en 2015

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

scientific article published on 13 February 2019

M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

artículo científico publicado en 2017

Missing Fragments: Detecting Cooperative Binding in Fragment-Based Drug Design

artículo científico publicado en 2012

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity

artículo científico publicado en 2009

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

artículo científico publicado en 2016

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

artículo científico publicado en 2015

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

artículo científico publicado en 2015

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2.

artículo científico publicado en 2017

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

artículo científico publicado en 2016

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction

artículo científico publicado en 2016

Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.

artículo científico publicado en 2017

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

artículo científico publicado en 2014

X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2.

artículo científico publicado en 2016

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17

artículo científico publicado en 2015

Lista de obras de Nyssa Drinkwater

Circumventing the stability-function trade-off in an engineered FN3 domain

Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

Crystal structure of a β-aminopeptidase from an Australian Burkholderia sp.

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

From crystal to compound: structure-based antimalarial drug discovery

Human immunoglobulin E flexes between acutely bent and extended conformations.

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

Missing Fragments: Detecting Cooperative Binding in Fragment-Based Drug Design

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2.

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction

Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2.

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17