Lista de obras - Andrew M Stern - Dominio Público Uruguay

A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.

artículo científico publicado en 2016

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

artículo científico publicado en 2012

A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes

artículo científico publicado en 2018

A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases

artículo científico publicado en 1994

A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities

artículo científico publicado en 2014

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

artículo científico publicado en 2013

Biologically Relevant Heterogeneity: Metrics and Practical Insights

artículo científico publicado en 2017

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.

artículo científico publicado en 2018

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

artículo científico publicado en 2017

Development of a carbon dioxide-capture assay in microtiter plate for aspartyl-beta-hydroxylase

artículo científico publicado en 1999

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

artículo científico publicado en 2016

Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.

artículo científico publicado en 2013

Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture ⬇️

artículo científico publicado el 10 de enero de 1996

Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression, fibrinogen binding, and microaggregate formation in a phase I dose-finding study: no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa a

artículo científico publicado en 2003

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

artículo científico publicado en 2015

Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated

artículo científico publicado en 2002

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

artículo científico publicado en 2002

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis

artículo científico publicado en 2000

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

artículo científico publicado en 2012

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery

artículo científico publicado en 2014

Influence of a natural and a synthetic inhibitor of factor XIIIa on fibrin clot rheology.

artículo científico publicado en 1999

Invertebrate aspartyl/asparaginyl beta-hydroxylase: potential modification of endogenous epidermal growth factor-like modules.

artículo científico publicado en 1992

Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity.

artículo científico publicado en 2005

Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.

artículo científico publicado en 2017

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.

artículo científico publicado en 2002

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

artículo científico publicado en 2015

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

artículo científico publicado en 2013

Novel inhibitors against the transglutaminase-catalysed crosslinking of lens proteins.

artículo científico publicado en 1998

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma

artículo científico publicado en 1996

Peripheral metabolism of [35S]parathyroid hormone in vivo: influence of alterations in calcium availability and parathyroid status

artículo científico publicado en 1989

Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.

artículo científico publicado en 2017

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.

artículo científico publicado en 2016

Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing.

artículo científico publicado en 2000

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

artículo científico publicado en 2000

Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia

artículo científico publicado en 2002

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

artículo científico publicado en 2011

Regulation of clot retraction by glycoprotein IIb/IIIa antagonists.

artículo científico publicado en 2002

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL ⬇️

artículo científico publicado el 13 de septiembre de 2011

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability ⬇️

artículo científico publicado el 9 de febrero de 2012

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones

scientific article published on 01 August 2000

Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients

artículo científico publicado en 2015

Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks

artículo científico publicado en 2020

The five cysteine residues located in the active site region of bovine aspartyl (asparaginyl) beta-hydroxylase are not essential for catalysis

artículo científico publicado en 1998

Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation

artículo científico publicado en 1994

Treating gynecologic malignancies with selective estrogen receptor downregulators (SERDs): promise and challenges.

artículo científico publicado en 2015

Lista de obras de Andrew M Stern

A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes

A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases

A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

Biologically Relevant Heterogeneity: Metrics and Practical Insights

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Development of a carbon dioxide-capture assay in microtiter plate for aspartyl-beta-hydroxylase

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.

Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture ⬇️

Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression, fibrinogen binding, and microaggregate formation in a phase I dose-finding study: no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa a

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery

Influence of a natural and a synthetic inhibitor of factor XIIIa on fibrin clot rheology.

Invertebrate aspartyl/asparaginyl beta-hydroxylase: potential modification of endogenous epidermal growth factor-like modules.

Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity.

Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

Novel inhibitors against the transglutaminase-catalysed crosslinking of lens proteins.

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma

Peripheral metabolism of [35S]parathyroid hormone in vivo: influence of alterations in calcium availability and parathyroid status

Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.

Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing.

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Regulation of clot retraction by glycoprotein IIb/IIIa antagonists.

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL ⬇️

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability ⬇️

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones

Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients

Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks

The five cysteine residues located in the active site region of bovine aspartyl (asparaginyl) beta-hydroxylase are not essential for catalysis

Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation

Treating gynecologic malignancies with selective estrogen receptor downregulators (SERDs): promise and challenges.