Lista de obras - Albert M Berghuis - Dominio Público Uruguay

A recurrent PDGFRB mutation causes familial infantile myofibromatosis

artículo científico publicado en 2013

A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni

artículo científico publicado en 2004

An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.

artículo científico publicado en 2016

Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia

artículo científico publicado en 2016

Biophysics in Canada

artículo científico publicado en 2017

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

artículo científico publicado en 2011

Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme

artículo científico publicado en 2016

Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor

artículo científico publicado en 2011

Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism

artículo científico publicado en 2005

Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: substrate specificity in udp-hexose 4-epimerases

artículo científico publicado en 2004

Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases

artículo científico publicado en 2005

Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose

artículo científico publicado en 2001

Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases

artículo científico publicado en 2011

Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor

artículo científico publicado en 2009

Crystallization and Preliminary Crystallographic Studies of Giα1 and Mutants of Giα1 in the GTP and GDP-bound States

artículo científico publicado en 1994

Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae

artículo científico publicado en 1998

Crystallization and preliminary crystallographic analysis of 3'-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7.

artículo científico publicado en 2004

Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila

artículo científico publicado en 2005

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

artículo científico publicado en 2017

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

artículo científico publicado en 2014

Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells

artículo científico publicado en 2012

Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″-Ia

artículo científico publicado en 2017

Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment

artículo científico publicado el 5 de abril de 1992

Enzyme-Assisted Suicide

article published in 2003

Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity

artículo científico publicado en 2009

Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO

artículo científico publicado en 2007

Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation

scientific journal article

Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

artículo científico publicado en 2017

Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein

artículo científico publicado en 2010

Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors

artículo científico publicado en 2016

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

artículo científico publicado en 2020

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.

artículo científico publicado en 2017

Human isoprenoid synthase enzymes as therapeutic targets

artículo científico publicado en 2014

IRF8 mutations and human dendritic-cell immunodeficiency

artículo científico publicado en 2011

Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence

artículo científico publicado en 2006

Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication

artículo científico publicado en 2013

Inhibition of outer membrane proteases of the omptin family by aprotinin

artículo científico publicado en 2015

Isolation, Crystallization and Preliminary Diffraction Analyses of Human Pancreatic α-Amylase

scientific article published on 01 April 1993

LG-26GERMLINE AND SOMATIC FGFR1 ABNORMALITIES IN DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS.

artículo científico publicado en 2016

Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis

artículo científico publicado en 2014

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography ⬇️

artículo científico publicado el 6 de febrero de 1992

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

artículo científico publicado en 2005

Maintenance of native-like protein dynamics may not be required for engineering functional proteins

artículo científico publicado en 2014

Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop

artículo científico publicado en 2002

Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance

artículo científico publicado en 2009

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases

artículo científico publicado en 2014

Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment

artículo científico publicado en 1994

New phenolic inhibitors of yeast homoserine dehydrogenase

artículo científico publicado en 2004

Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure

artículo científico publicado en 2011

Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides.

artículo científico publicado en 2013

Oxidation state-dependent conformational changes in cytochrome c

artículo científico publicado el 20 de febrero de 1992

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase

artículo científico publicado en 2017

Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia.

artículo científico publicado en 2018

Preparation and characterization of bacterial protein complexes for structural analysis

artículo científico publicado en 2009

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase

artículo científico publicado en 2015

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

artículo científico

Protein kinase inhibitors and antibiotic resistance

artículo científico publicado en 2002

Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate

artículo científico publicado en 2010

Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-Acetyltransferases

artículo científico publicado en 2005

Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure

artículo científico publicado en 2012

Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design

artículo científico publicado en 2016

Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases

artículo científico publicado en 2012

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.

artículo científico publicado en 2017

Structural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics

artículo científico publicado en 2009

Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A

artículo científico publicado en 2013

Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase

artículo científico publicado en 2007

Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b

artículo científico publicado en 2007

Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity

artículo científico publicado en 2006

Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae

artículo científico publicado en 2007

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

artículo científico publicado en 2014

Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila

artículo científico publicado en 2010

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold ⬇️

artículo científico publicado el 24 de marzo de 1995

Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses.

artículo científico publicado en 2005

Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

artículo científico publicado en 2002

Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme

artículo científico publicado en 2014

Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases

artículo científico publicado en 2006

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

artículo científico publicado en 2012

The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance

artículo científico publicado en 1999

The Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like Conformation

artículo científico publicado en 2012

The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c

artículo científico publicado en 1994

The role of a conserved water molecule in the redox-dependent thermal stability of iso-1-cytochrome c.

artículo científico publicado en 1996

The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure

artículo científico publicado en 2016

The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation

artículo científico publicado en 2008

Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition

artículo científico publicado en 2013

Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP.

artículo científico publicado en 2005

X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members

artículo científico publicado en 2003

YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics

artículo científico publicado en 2002

ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

scientific article published on 22 January 2020

Lista de obras de Albert M Berghuis

A recurrent PDGFRB mutation causes familial infantile myofibromatosis

A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni

An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.

Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia

Biophysics in Canada

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme

Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor

Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism

Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: substrate specificity in udp-hexose 4-epimerases

Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases

Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose

Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases

Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor

Crystallization and Preliminary Crystallographic Studies of Giα1 and Mutants of Giα1 in the GTP and GDP-bound States

Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae

Crystallization and preliminary crystallographic analysis of 3'-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7.

Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells

Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″-Ia

Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment

Enzyme-Assisted Suicide

Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity

Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO

Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation

Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein

Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.

Human isoprenoid synthase enzymes as therapeutic targets

IRF8 mutations and human dendritic-cell immunodeficiency

Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence

Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication

Inhibition of outer membrane proteases of the omptin family by aprotinin

Isolation, Crystallization and Preliminary Diffraction Analyses of Human Pancreatic α-Amylase

LG-26GERMLINE AND SOMATIC FGFR1 ABNORMALITIES IN DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS.

Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography ⬇️

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

Maintenance of native-like protein dynamics may not be required for engineering functional proteins

Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop

Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases

Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment

New phenolic inhibitors of yeast homoserine dehydrogenase

Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure

Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides.

Oxidation state-dependent conformational changes in cytochrome c

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase

Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia.

Preparation and characterization of bacterial protein complexes for structural analysis

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

Protein kinase inhibitors and antibiotic resistance

Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate

Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-Acetyltransferases

Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure

Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design

Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.

Structural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics

Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A

Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase

Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b

Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity

Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold ⬇️

Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses.

Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme

Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance

The Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like Conformation