Lista de obras - Adam Yasgar - Dominio Público Uruguay

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth

artículo científico publicado en 2014

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

artículo científico publicado en 2017

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

artículo científico publicado en 2016

A Homogeneous Platform to Discover Inhibitors of the GoLoco Motif/G-alpha Interaction

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

artículo científico publicado en 2016

A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding

artículo científico publicado en 2014

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

artículo científico publicado en 2008

A high-throughput 1,536-well luminescence assay for glutathione S-transferase activity

artículo científico publicado en 2010

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

artículo científico publicado en 2022

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase

artículo científico publicado en 2009

AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions

artículo científico publicado en 2016

Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase

artículo científico publicado en 2016

Compound Management for Quantitative High-Throughput Screening

artículo científico publicado en 2008

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

artículo científico publicado en 2018

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

artículo científico publicado en 2016

Current approaches for the discovery of drugs that deter substance and drug abuse

artículo científico publicado en 2014

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

artículo científico publicado en 2018

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

artículo científico publicado en 2015

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

artículo científico publicado en 2018

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

artículo científico publicado en 2013

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

artículo científico publicado en 2007

Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

artículo científico publicado en 2006

Fluorescence polarization assays in high-throughput screening and drug discovery: a review

artículo científico publicado en 2016

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

artículo científico publicado en 2006

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding

artículo científico publicado en 2012

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

artículo científico publicado en 2014

High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe

artículo científico publicado en 2013

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models

artículo científico publicado en 2019

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold

artículo científico publicado en 2017

Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor

scientific article published on 10 June 2013

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies

artículo científico publicado en 2014

Preparation of FRET reporters to support chemical probe development

artículo científico publicado en 2010

Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

artículo científico publicado en 2017

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

artículo científico publicado en 2008

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

artículo científico publicado en 2006

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

scientific journal article

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors

artículo científico publicado en 2013

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

artículo científico publicado en 2014

Testing for drug-human serum albumin binding using fluorescent probes and other methods

artículo científico publicado en 2018

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

artículo científico publicado en 2011

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

artículo científico publicado en 2020

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors

artículo científico publicado en 2020

Lista de obras de Adam Yasgar

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

A Homogeneous Platform to Discover Inhibitors of the GoLoco Motif/G-alpha Interaction

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

A high-throughput 1,536-well luminescence assay for glutathione S-transferase activity

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase

AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions

Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase

Compound Management for Quantitative High-Throughput Screening

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Current approaches for the discovery of drugs that deter substance and drug abuse

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

Fluorescence polarization assays in high-throughput screening and drug discovery: a review

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold

Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies

Preparation of FRET reporters to support chemical probe development

Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Testing for drug-human serum albumin binding using fluorescent probes and other methods

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors