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Lista de obras de Bjørn Tore Gjertsen

0729. Interstitial changes in spleen during sepsis.

artículo científico publicado en 2014

4-Alkylated Silver-N-Heterocyclic Carbene (NHC) Complexes with Cytotoxic Effects in Leukemia Cells

artículo científico publicado en 2015

8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line.

artículo científico publicado en 1995

A Comparison of p53 Isoform Profiles and Apoptosis Induced by Camptothecin or a Herbal Khat Extract (<i>Catha Edulis (Vahl) Forssk. ex Endl.</i>) in Leukemic Cell Lines: Exploring Cellular Responses in Therapy Development

artículo científico publicado en 2020

A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia

artículo científico publicado en 2006

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

artículo científico publicado en 2016

A phase II study of elacytarabine in combination with idarubicin and of human equilibrative nucleoside transporter 1 expression in patients with acute myeloid leukemia and persistent blasts after the first induction course

scientific article published on 24 January 2014

A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid.

artículo científico publicado en 2008

Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death

artículo científico publicado en 2008

Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation

artículo científico publicado en 2010

Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients

artículo científico publicado en 2014

Acute myelogenous leukemia in a patient with Li-Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report

artículo científico publicado en 2006

Acute myelogenous leukemia with internal tandem duplication of the Flt3 gene appearing or altering at the time of relapse: a report of two cases.

artículo científico publicado en 2002

Adaptive contrast enhancement of two-dimensional electrophoretic protein gel images facilitates visualization, orientation and alignment.

artículo científico publicado en 2006

Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses

artículo científico publicado en 2002

Animal models of acute myelogenous leukaemia - development, application and future perspectives.

artículo científico publicado en 2005

Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.

artículo científico publicado en 2016

Antiangiogenic therapy in acute myelogenous leukemia: targeting of vascular endothelial growth factor and interleukin 8 as possible antileukemic strategies

artículo científico publicado en 2005

Antiapoptotic effect of heterozygously expressed mutant RI (Ala336-->Asp) subunit of cAMP kinase I in a rat leukemia cell line

artículo científico publicado en 1993

Anticancer immunotherapy in combination with proapoptotic therapy

artículo científico publicado en 2008

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

artículo científico publicado en 2009

Bcl-2 antisense in the treatment of human malignancies: a delusion in targeted therapy

scientific article published on December 2007

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

artículo científico publicado en 2012

CD34 expression in native human acute myelogenous leukemia blasts: Differences in CD34 membrane molecule expression are associated with different gene expression profiles

article

CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation

artículo científico publicado en 2005

Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines

artículo científico publicado en 2009

Cancer therapy targeted at cellular signal transduction mechanisms: strategies, clinical results, and unresolved issues

artículo científico publicado en 2009

Caspase I-related protease inhibition retards the execution of okadaic acid- and camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL-60 cells.

artículo científico publicado en 1999

Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis

artículo científico publicado en 2004

Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial

artículo científico publicado en 2018

Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment

artículo científico publicado en 2010

Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex

scientific article published on 01 June 2007

Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis.

artículo científico publicado en 1994

Clinical proteomics of myeloid leukemia

artículo científico publicado en 2010

Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia--a report of five cases

artículo científico publicado en 2010

Comparison of nucleic acid targets prepared from total RNA or poly(A) RNA for DNA oligonucleotide microarray hybridization

artículo científico publicado en 2007

Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia.

artículo científico publicado en 2011

Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables

artículo científico publicado en 2006

Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid

artículo científico publicado en 2012

Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis

artículo científico publicado en 2013

Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients.

artículo científico publicado en 2007

Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006).

artículo científico publicado en 2014

Development of Personalized Molecular Therapy for Acute Myeloid Leukemia

artículo científico

Developmental Therapeutics Consortium report on study design effects on trial outcomes in chronic myeloid leukaemia

artículo científico

Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

artículo científico publicado en 2015

Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells

artículo científico publicado en 2017

Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment

artículo científico publicado en 2012

Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine

artículo científico publicado en 2013

Drug Repurposing for the Treatment of Acute Myeloid Leukemia

artículo científico publicado en 2017

Early gene expression of acute myeloid leukemia in response to chemotherapy

artículo científico publicado en 2007

Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells.

artículo científico publicado en 2009

Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines

artículo científico publicado en 2012

Effects of interferon gamma on native human acute myelogenous leukaemia cells

artículo científico publicado en 2006

Elevated monocyte phosphorylated p38 in nearby employees after a chemical explosion

artículo científico publicado en 2016

Erythropoietin a safe bet in haemorrhagic shock?

scientific article published on 01 May 2008

Expression of Fc(epsilon)-receptors by human acute myelogenous leukemia (AML) blasts: studies of high- and low- (CD23) affinity receptor expression and the effects of IgE-mediated receptor ligation on functional AML blast characteristics

artículo científico publicado en 2002

Expression of TP53 isoforms p53β or p53γ enhances chemosensitivity in TP53(null) cell lines.

artículo científico publicado en 2013

Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation

artículo científico publicado en 2015

Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.

artículo científico publicado en 2011

Fas/APO-1(CD95)-induced apoptosis of primary hepatocytes is inhibited by cAMP.

artículo científico publicado en 1997

Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis

artículo científico publicado en 1995

First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma

artículo científico publicado en 2014

Flow cytometric measurement of apoptosis and necrosis in cryopreserved PBPC concentrates from patients with malignant diseases

artículo científico publicado en 2002

Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53

artículo científico publicado en 2006

Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities.

artículo científico publicado en 2003

Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors

artículo científico publicado en 2007

Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen

artículo científico publicado en 2013

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells

scholarly article by Beibei Zhang et al published May 2019 in Haematologica

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells.

artículo científico publicado en 2018

Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes.

artículo científico publicado en 1997

Gel2DE - a software tool for correlation analysis of 2D gel electrophoresis data

artículo científico publicado en 2013

Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia

artículo científico publicado en 2009

Global gene expression in classification, pathogenetic understanding and identification of therapeutic targets in acute myeloid leukemia

scientific article published on December 2007

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.

artículo científico publicado en 2016

High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma.

artículo científico publicado en 2018

Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents

artículo científico publicado en 2013

Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell.

scientific article published on December 2007

How should clinical data be included in experimental studies of cancer immunology?

artículo científico publicado en 2004

Human cells and the Norwegian Health Research Act.

artículo científico publicado en 2012

Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia

artículo científico publicado en 2016

Hypoxia increases HIF-1α expression and constitutive cytokine release by primary human acute myeloid leukaemia cells

artículo científico publicado en 2010

IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia

artículo científico publicado en 2022

Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis ⬇️

artículo científico publicado el 22 de marzo de 2011

Immunogenic effects of recombinant interferon-beta therapy disrupt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis.

artículo científico publicado en 2012

Immunotherapy in chronic lymphocytic leukemia

artículo científico publicado en 2005

Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

artículo científico publicado en 2013

In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL.

artículo científico publicado en 2017

In vitro crosstalk between fibroblasts and native human acute myelogenous leukemia (AML) blasts via local cytokine networks results in increased proliferation and decreased apoptosis of AML cells as well as increased levels of proangiogenic Interleu

artículo científico publicado en 2005

In vitro culture of human acute myelogenous leukemia (AML) cells in serum-free media: studies of native AML blasts and AML cell lines

artículo científico publicado en 2000

In vivo biological effects of ATRA in the treatment of AML

artículo científico publicado en 2008

In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization.

artículo científico publicado en 2007

Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors

artículo científico publicado en 2013

Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model

artículo científico publicado en 2009

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

artículo científico publicado en 2013

Influence of p53 Isoform Expression on Survival in High-Grade Serous Ovarian Cancers

article published in 2019

Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leukemia Virus Type 1 (HTLV-1) Transmission by Cytarabine

artículo científico publicado en 2018

Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells

artículo científico publicado en 2010

Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants

artículo científico publicado en 2015

Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid.

artículo científico publicado en 2012

Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis

artículo científico publicado en 2003

Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia?

artículo científico publicado en 2005

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

artículo científico publicado en 2017

Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells

artículo científico publicado en 2004

Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts.

artículo científico publicado en 2008

LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro

artículo científico publicado en 2007

Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia

artículo científico publicado en 2010

Leptin in human acute myelogenous leukemia: studies of in vivo levels and in vitro effects on native functional leukemia blasts

scientific article published on 01 June 2002

Leukocyte p53 protein biosignature through standard-aligned two-dimensional immunoblotting

artículo científico publicado en 2012

Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells

artículo científico publicado en 2008

Maternal exposure to gasoline and exhaust increases the risk of childhood leukaemia in offspring - a prospective study in the Norwegian Mother and Child Cohort Study

scientific article published on 15 October 2018

Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation.

artículo científico publicado en 2012

Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells

artículo científico publicado en 1993

Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells

artículo científico publicado en 2003

Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia

scientific article published on 20 May 2019

Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia

artículo científico publicado en 2014

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

scholarly article by Robert J Kreitman et al published August 2018 in Leukemia

Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line.

artículo científico publicado en 1994

Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia

artículo científico publicado en 2012

NK cell dynamics and association with molecular response in early chronic phase chronic myelogenous leukemia (CML-CP) patients treated with nilotinib

artículo científico publicado en 2017

Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer

artículo científico publicado en 2012

Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action

artículo científico publicado en 1995

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

artículo científico publicado en 2014

Nuclear factor-kappaB signaling: a contributor in leukemogenesis and a target for pharmacological intervention in human acute myelogenous leukemia

artículo científico publicado en 2009

Osteoblasts increase proliferation and release of pro-angiogenic interleukin 8 by native human acute myelogenous leukemia blasts.

artículo científico publicado en 2004

Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

scientific article published on 10 July 2020

Patterns of cell death induced by eluates from denture base acrylic resins in U-937 human monoblastoid cells

scientific article published on 01 February 2000

Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines.

artículo científico

Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis

Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia

artículo científico publicado en 2017

Potentiated phospho-protein networks in cancer cells

Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells

artículo científico publicado en 2007

Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators.

artículo científico

Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line

artículo científico publicado en 1991

Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB.

artículo científico publicado en 2009

Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML.

artículo científico publicado en 2006

Protein phosphorylation in apoptosis.

artículo científico publicado en 1995

Proteomic strategies for individualizing therapy of acute myeloid leukemia (AML).

artículo científico publicado en 2006

Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies

artículo científico publicado en 2006

Proteomics in acute myelogenous leukaemia (AML): methodological strategies and identification of protein targets for novel antileukaemic therapy

artículo científico publicado en 2005

Proteomics of p53 in diagnostics and therapy of acute myeloid leukemia

artículo científico publicado en 2006

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia

artículo científico publicado en 2016

Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels

scientific article published on 18 October 2007

Restoration of bax in prostate cancer suppresses tumor growth and augments therapeutic cell death induction.

artículo científico publicado en 2001

Review: genetic models of acute myeloid leukaemia

artículo científico publicado en 2008

Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients

artículo científico publicado en 2004

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells

artículo científico publicado en 2014

Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients

artículo científico publicado en 2016

Sensitive and rapid detection of beta-galactosidase expression in intact cells by microinjection of fluorescent substrate

artículo científico publicado en 1995

Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells.

artículo científico publicado en 2016

Single Cell Detection of the p53 Protein by Mass Cytometry

artículo científico publicado en 2020

Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib

artículo científico

Single cell profiling of potentiated phospho-protein networks in cancer cells.

artículo científico publicado en 2004

Single-cell proteomics: potential implications for cancer diagnostics

artículo científico publicado en 2016

Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma

artículo científico publicado en 2016

Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft.

artículo científico publicado en 2014

Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia

artículo científico publicado en 2011

Stratification of pediatric acute myeloid leukemia through cancer cell gene-expression profiling ⬇️

artículo científico publicado el 1 de marzo de 2011

Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90

artículo científico publicado en 2006

Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells

artículo científico publicado en 2007

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.

artículo científico publicado en 2011

T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005

artículo científico publicado en 2006

Targeted Therapy of FLT3 in Treatment of AML-Current Status and Future Directions

artículo científico publicado en 2014

Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: Will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions?

artículo científico

Targeted therapy in acute myeloid leukaemia: current status and future directions

artículo científico publicado en 2009

Targeting of polo-like kinases and their cross talk with Aurora kinases--possible therapeutic strategies in human acute myeloid leukemia?

artículo científico

The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer

artículo científico publicado en 2016

The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia

scientific article published on August 2013

The effect of chemotherapeutics on cell-to-cell transport of HTLV-1 and the p8 protein through membrane nanotubes.

artículo científico publicado en 2015

The genetic subtypes of cAMP-dependent protein kinase--functionally different or redundant?

artículo científico publicado en 1993

The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells

artículo científico publicado en 2007

The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity

artículo científico publicado en 2010

The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells

artículo científico publicado en 2009

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

artículo científico publicado en 1991

Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML.

artículo científico publicado en 2017

Total synthesis intermediates as a molecule treasure chest:  hit to leads with cytotoxic effect in leukemic cells

scientific article published on 31 March 2020

Treatment with valproic acid, all-trans retinoic acid (ATRA) and theophyllamine for 9 days caused a persistent increase in peripheral blood platelet counts for a patient with acute myelogenous leukemia

scientific article published on 01 January 2006

Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML).

artículo científico publicado en 2016

Tunneling nanotube (TNT) formation is independent of p53 expression.

artículo científico publicado en 2013

Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison.

artículo científico publicado en 2018

Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia.

artículo científico publicado en 2017

Tyrosine kinase inhibitors and interferon-α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines

scientific article published on 16 January 2020

Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors

artículo científico publicado en 1999

Untangling the intracellular signalling network in cancer--a strategy for data integration in acute myeloid leukaemia

artículo científico publicado en 2010

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

artículo científico publicado en 2014

Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells

artículo científico publicado en 2002

[Finding a cancer cell - and determining its origin]

artículo científico publicado en 2011

[Is high hemoglobin level dangerous?]

artículo científico publicado en 2009

[The mechanism of apoptosis--therapeutic possibilities in cancer]

artículo científico publicado en 2000

[Towards a more specific cancer treatment?]

artículo científico publicado en 2014

cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases

artículo científico publicado en 2013

cDNA microarray analysis of non-selected cases of acute myeloid leukemia demonstrates distinct clustering independent of cytogenetic aberrations and consistent with morphological signs of differentiation

scientific article published on 01 May 2006

ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab

scientific article published on 25 November 2019

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