Lista de obras - K Sambamurti - Dominio Público Uruguay

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

artículo científico publicado en 2001

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

artículo científico publicado en 2010

A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.

artículo científico publicado en 2006

Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation

artículo científico publicado en 2006

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

artículo científico publicado en 2003

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

artículo científico publicado en 2003

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease

artículo científico publicado en 2015

Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment.

artículo científico publicado en 2014

An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice.

artículo científico publicado en 2008

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

artículo científico publicado en 1999

Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model.

artículo científico

Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD)

artículo científico publicado en 2015

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

artículo científico publicado en 2003

Beta-secretase: structure, function, and evolution

artículo científico publicado en 2008

Challenges associated with metal chelation therapy in Alzheimer's disease

artículo científico publicado en 2009

Characterization of recombinant, soluble beta-secretase from an insect cell expression system.

artículo científico publicado en 2001

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

artículo científico publicado en 2004

DNA replication-blocking properties of adducts formed by aflatoxin B1-2,3-dichloride and aflatoxin B1-2,3-oxide

artículo científico publicado en 1987

Differential accumulation of secreted AbetaPP metabolites in ocular fluids

artículo científico publicado en 2010

Differential expression of cholesterol hydroxylases in Alzheimer's disease

artículo científico publicado en 2004

Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease

artículo científico publicado en 2011

Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model.

artículo científico publicado en 2008

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

article by Ann-Charlotte Granholm et al published 4 June 2008 in Journal of Alzheimer's Disease

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

artículo científico publicado en 1992

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

artículo científico publicado en 2014

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

artículo científico publicado en 2014

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

artículo científico publicado en 2010

Gene structure and organization of the human beta-secretase (BACE) promoter.

artículo científico publicado en 2004

Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.

artículo científico publicado en 2007

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

artículo científico publicado en 2003

Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins

scientific article published on 01 June 1995

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.

artículo científico publicado en 2008

Higher incidence of mild cognitive impairment in familial hypercholesterolemia

artículo científico publicado en 2010

Human retinal pigment epithelium cells as functional models for the RPE in vivo.

artículo científico publicado en 2011

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

artículo científico publicado en 2006

Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert ⬇️

artículo científico publicado el 1 de mayo de 1991

Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury

artículo científico publicado en 2014

Insulysin cleaves the APP cytoplasmic fragment at multiple sites.

artículo científico publicado en 2007

Mutagenesis by aflatoxin in M13 DNA: base-substitution mechanisms and the origin of strand bias.

artículo científico publicado en 1989

Neuronutrition and Alzheimer's disease

artículo científico publicado en 2010

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF- Inhibitors, and GLP-1 Receptor Agonists

artículo científico publicado en 2004

Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase

artículo científico publicado en 2009

Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents.

artículo científico publicado en 2004

Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes

artículo científico publicado en 1998

Resolution of inflammation is altered in Alzheimer's disease

artículo científico publicado en 2014

Role of DNA dynamics in Alzheimer's disease

artículo científico publicado en 2008

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

artículo científico publicado en 2005

Sequence context effects in DNA replication blocks induced by aflatoxin B1

artículo científico publicado en 1985

Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and [...]

artículo científico publicado en 2013

TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

artículo científico publicado en 2007

Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors

artículo científico publicado en 2006

Targets for AD treatment: conflicting messages from γ-secretase inhibitors

artículo científico publicado en 2011

The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans‐Golgi Network or in a Post‐Golgi Compartment a ⬇️

artículo científico publicado el 31 de diciembre de 1992

The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.

artículo científico publicado en 2012

The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells ⬇️

artículo científico publicado el 1 de enero de 1997

The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.

artículo científico publicado en 2006

The heat shock/oxidative stress connection. Relevance to Alzheimer disease.

artículo científico publicado en 1996

The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.

artículo científico publicado en 1998

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.

artículo científico publicado en 2018

Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice

artículo científico publicado en 2011

When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author.

artículo científico publicado en 2017

Lista de obras de K Sambamurti

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.

Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease

Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment.

An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice.

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model.

Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD)

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

Beta-secretase: structure, function, and evolution

Challenges associated with metal chelation therapy in Alzheimer's disease

Characterization of recombinant, soluble beta-secretase from an insect cell expression system.

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

DNA replication-blocking properties of adducts formed by aflatoxin B1-2,3-dichloride and aflatoxin B1-2,3-oxide

Differential accumulation of secreted AbetaPP metabolites in ocular fluids

Differential expression of cholesterol hydroxylases in Alzheimer's disease

Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease

Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model.

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

Gene structure and organization of the human beta-secretase (BACE) promoter.

Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.

Higher incidence of mild cognitive impairment in familial hypercholesterolemia

Human retinal pigment epithelium cells as functional models for the RPE in vivo.

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert ⬇️

Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury

Insulysin cleaves the APP cytoplasmic fragment at multiple sites.

Mutagenesis by aflatoxin in M13 DNA: base-substitution mechanisms and the origin of strand bias.

Neuronutrition and Alzheimer's disease

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF- Inhibitors, and GLP-1 Receptor Agonists

Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase

Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents.

Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes

Resolution of inflammation is altered in Alzheimer's disease

Role of DNA dynamics in Alzheimer's disease

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

Sequence context effects in DNA replication blocks induced by aflatoxin B1

Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and [...]

TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors

Targets for AD treatment: conflicting messages from γ-secretase inhibitors

The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans‐Golgi Network or in a Post‐Golgi Compartment a ⬇️

The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.

The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells ⬇️

The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.

The heat shock/oxidative stress connection. Relevance to Alzheimer disease.

The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.

Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice

When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author.