Lista de obras - Shane M Devine - Dominio Público Uruguay

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

artículo científico publicado en 2019

A Structure-Activity Relationship Study of Bitopic N6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

artículo científico publicado en 2018

An allosteric modulator of the adenosine A1 receptor improves cardiac function following ischaemia in murine isolated hearts.

artículo científico publicado en 2013

Antimalarial drug discovery targeting apical membrane antigen 1

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK.

artículo científico publicado en 2014

Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening

article

Dual acting antioxidant A1 adenosine receptor agonists.

artículo científico publicado en 2007

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

scientific article published on 13 February 2019

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.

artículo científico publicado en 2014

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

artículo científico publicado en 2014

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

scientific article published on 13 December 2019

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

artículo científico publicado en 2015

Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.

artículo científico publicado en 2013

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

artículo científico publicado en 2016

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

artículo científico publicado en 2014

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

artículo científico publicado en 2018

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

artículo científico publicado en 2012

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

artículo científico publicado en 2010

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

artículo científico publicado en 2019

VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model.

artículo científico publicado en 2016

Lista de obras de Shane M Devine

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

A Structure-Activity Relationship Study of Bitopic N6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

An allosteric modulator of the adenosine A1 receptor improves cardiac function following ischaemia in murine isolated hearts.

Antimalarial drug discovery targeting apical membrane antigen 1

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK.

Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening

Dual acting antioxidant A1 adenosine receptor agonists.

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model.