Lista de obras - Lina M Obeid - Dominio Público Uruguay

A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation

artículo científico publicado en 2011

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

artículo científico publicado en 2006

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

artículo científico publicado en 2005

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

artículo científico publicado en 2007

A role of sphingosine kinase 1 in head and neck carcinogenesis

artículo científico publicado en 2011

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.

artículo científico publicado en 2009

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

artículo científico publicado en 2011

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

artículo científico publicado en 2009

Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.

artículo científico publicado en 2006

Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.

artículo científico

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells

artículo científico publicado en 2007

An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown ⬇️

artículo científico publicado el 1 de enero de 2010

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

artículo científico publicado en 1996

Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

artículo científico publicado en 2002

Bioactive sphingolipids in the modulation of the inflammatory response.

artículo científico publicado en 2006

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

artículo científico publicado en 2002

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

artículo científico publicado en 2011

Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells

artículo científico publicado en 2006

Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.

artículo científico publicado en 2012

Ceramide and the regulation of apoptosis and the stress response.

artículo científico publicado en 1996

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells

artículo científico publicado en 2008

Ceramide inhibits phospholipase D in a cell-free system

artículo científico publicado en 1996

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

artículo científico publicado en 2009

Ceramide synthases at the centre of sphingolipid metabolism and biology

artículo científico publicado en 2012

Ceramide: a stress signal and mediator of growth suppression and apoptosis.

artículo científico publicado en 1995

Ceramide: an endogenous regulator of apoptosis and growth suppression.

artículo científico publicado en 1995

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

scientific journal article

Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.

artículo científico publicado en 2006

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

artículo científico publicado en 2012

Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

scientific article published on 01 November 2019

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

artículo científico publicado en 2001

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

artículo científico publicado en 2008

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

artículo científico publicado en 2002

Defining a role for sphingosine kinase 1 in p53-dependent tumors.

artículo científico publicado en 2011

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+ Loading Capacity and Promotes Apoptosis ⬇️

artículo científico publicado el 10 de diciembre de 2010

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis

artículo científico publicado en 2006

Dihydroceramide-based response to hypoxia

scientific article published in 2012

Dihydroceramide-based response to hypoxia.

artículo científico publicado en 2011

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

artículo científico publicado en 2005

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.

artículo científico publicado en 2009

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease

artículo científico publicado en 2014

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

artículo científico publicado en 2004

Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages

artículo científico publicado en 2007

Effect of sphingosine kinase 1 inhibition on blood pressure ⬇️

artículo científico publicado el 29 de octubre de 2012

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.

artículo científico publicado en 2013

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

artículo científico publicado en 1997

Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.

artículo científico publicado en 2000

Functions of neutral ceramidase in the Golgi apparatus

artículo científico publicado en 2018

Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis

artículo científico publicado en 2010

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

artículo científico publicado en 1998

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

artículo científico publicado en 2006

Golgi fragmentation is associated with ceramide-induced cellular effects.

artículo científico publicado en 2005

Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells

artículo científico

ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae

artículo científico publicado en 2009

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase ⬇️

artículo científico publicado el 7 de noviembre de 1997

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

artículo científico publicado en 2011

Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity

scientific article published on 01 April 2001

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

artículo científico publicado en 2012

Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis

artículo científico publicado en 2013

Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase

artículo científico publicado en 2002

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

artículo científico publicado en 2006

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

artículo científico publicado en 2011

Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells

artículo científico publicado en 2003

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

artículo científico publicado en 1997

Isc1 regulates sphingolipid metabolism in yeast mitochondria.

artículo científico publicado en 2007

Isolated atlantoaxial subluxation as the presenting manifestation of inflammatory bowel disease

artículo científico publicado en 1986

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease ⬇️

artículo científico publicado el 31 de agosto de 2012

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

artículo científico publicado en 2005

Many ceramides.

artículo científico publicado en 2011

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

artículo científico publicado en 2010

Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.

artículo científico publicado en 2006

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

artículo científico publicado en 2003

Molecular targeting of acid ceramidase: implications to cancer therapy.

artículo científico publicado en 2008

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

artículo científico publicado en 2006

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner ⬇️

artículo científico publicado el 24 de julio de 2012

Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells.

artículo científico publicado en 2006

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

artículo científico publicado en 2002

PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

artículo científico publicado en 2019

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation

artículo científico publicado en 2011

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

artículo científico publicado en 2005

Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.

artículo científico publicado en 2006

Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases

artículo científico publicado en 2019

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

artículo científico publicado en 2006

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase ⬇️

artículo científico publicado el 18 de febrero de 2011

Regulation of cyclin-dependent kinase 2 activity by ceramide

artículo científico publicado en 2000

Regulation of protein kinase C and role in cancer biology.

artículo científico publicado en 1994

Role for ceramide in cell cycle arrest.

artículo científico publicado en 1995

Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells

artículo científico publicado en 2004

Role for sphingosine kinase 1 in colon carcinogenesis.

artículo científico publicado en 2008

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.

artículo científico publicado en 2010

Role of ceramide in cellular senescence

artículo científico publicado en 1995

Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

artículo científico publicado en 2003

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.

artículo científico publicado en 2010

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

artículo científico publicado en 2001

Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB.

artículo científico publicado en 1997

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

artículo científico publicado en 2010

Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis

artículo científico publicado en 2012

Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics ⬇️

artículo científico publicado el 12 de julio de 2013

Sphingolipids in mitochondria.

artículo científico publicado en 2016

Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis

scientific article published on 01 June 2000

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

artículo científico publicado en 2013

Sphingosine Kinase 1 in Cancer ⬇️

artículo científico publicado el 1 de enero de 2013

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

artículo científico publicado en 2004

Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity

artículo científico publicado en 2013

Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.

artículo científico publicado en 2007

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation

artículo científico publicado en 2013

Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

artículo científico publicado en 2006

Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia

artículo científico publicado en 2011

Sphingosine-1-phosphate receptor 2

artículo científico publicado en 2013

Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis.

artículo científico publicado en 2004

Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy ⬇️

artículo científico publicado el 1 de agosto de 2011

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

artículo científico publicado en 2010

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner

artículo científico publicado en 2013

TNFα‐induced glutathione depletion lies downstream of cPLA2 in L929 cells ⬇️

artículo científico publicado el 26 de octubre de 2001

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

scientific article published on 04 January 2021

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors ⬇️

artículo científico publicado el 16 de julio de 2012

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

artículo científico publicado en 2010

The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.

artículo científico publicado en 2014

The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.

artículo científico publicado en 2007

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

artículo científico publicado en 2003

Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2

scientific article published on 01 December 1997

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

artículo científico publicado en 2005

Use of yeast as a model system for studies of sphingolipid metabolism and signaling

scientific article published on 01 January 2000

Yeast sphingolipid metabolism: clues and connections.

artículo científico publicado en 2004

Yeast sphingolipids: metabolism and biology.

artículo científico publicado en 2002

Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function

artículo científico publicado en 2006

Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging.

artículo científico publicado en 2000

p53 and regulation of bioactive sphingolipids ⬇️

artículo científico publicado el 28 de octubre de 2010

Lista de obras de Lina M Obeid

A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

A role of sphingosine kinase 1 in head and neck carcinogenesis

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.

Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells

An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown ⬇️

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

Bioactive sphingolipids in the modulation of the inflammatory response.

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells

Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.

Ceramide and the regulation of apoptosis and the stress response.

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells

Ceramide inhibits phospholipase D in a cell-free system

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.

Ceramide synthases at the centre of sphingolipid metabolism and biology

Ceramide: a stress signal and mediator of growth suppression and apoptosis.

Ceramide: an endogenous regulator of apoptosis and growth suppression.

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

Defining a role for sphingosine kinase 1 in p53-dependent tumors.

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+ Loading Capacity and Promotes Apoptosis ⬇️

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis

Dihydroceramide-based response to hypoxia

Dihydroceramide-based response to hypoxia.

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages

Effect of sphingosine kinase 1 inhibition on blood pressure ⬇️

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.

Functions of neutral ceramidase in the Golgi apparatus

Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

Golgi fragmentation is associated with ceramide-induced cellular effects.

Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells

ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase ⬇️

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis

Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

Isc1 regulates sphingolipid metabolism in yeast mitochondria.

Isolated atlantoaxial subluxation as the presenting manifestation of inflammatory bowel disease

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease ⬇️

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

Many ceramides.

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

Molecular targeting of acid ceramidase: implications to cancer therapy.

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner ⬇️

Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells.

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation