Lista de obras - Costas Koumenis - Dominio Público Uruguay

"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways

artículo científico publicado en 2006

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.

artículo científico publicado en 2016

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

artículo científico publicado en 2017

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

artículo científico publicado en 2022

AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment

artículo científico publicado en 2016

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

artículo científico publicado en 2019

ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

artículo científico publicado en 2009

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

artículo científico publicado en 2015

Activating transcription factor 4 is translationally regulated by hypoxic stress

artículo científico publicado en 2004

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

scientific article published on 01 August 2019

Avoiding antiperspirants during breast radiation therapy: Myth or sound advice?

artículo científico publicado en 2017

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

artículo científico publicado en 2015

Control of the hypoxic response through regulation of mRNA translation.

artículo científico publicado en 2005

Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.

artículo científico publicado en 2002

Current Delivery Limitations of Proton PBS for FLASH

artículo científico publicado en 2020

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

scientific article published on 01 February 2020

Development of a stress response therapy targeting aggressive prostate cancer.

artículo científico publicado en 2018

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.

artículo científico publicado en 2010

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia.

artículo científico publicado en 2012

ER stress, hypoxia tolerance and tumor progression.

artículo científico publicado en 2006

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

artículo científico publicado en 2005

Effects of radiation quality and oxygen on clustered DNA lesions and cell death.

artículo científico publicado en 2011

Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia.

artículo científico publicado en 1994

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

artículo científico publicado en 2004

Evaluation of On- and Off-Line Bioluminescence Tomography System for Focal Irradiation Guidance. ⬇️

artículo científico publicado en 2016

Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.

artículo científico publicado en 2011

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

artículo científico publicado en 2015

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

artículo científico publicado en 2006

HIF and MIF--a nifty way to delay senescence?

artículo científico publicado en 2006

HIF-1alpha and p53: the ODD couple?

artículo científico publicado en 2005

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab.

artículo científico publicado en 2011

Hypoxia and the unfolded protein response.

artículo científico publicado en 2007

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library

artículo científico publicado en 2007

Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.

artículo científico publicado en 2012

Identification of three proteins in the eye of Aplysia, whose synthesis is altered by serotonin (5-HT). Possible involvement of these proteins in the ocular circadian system

artículo científico publicado en 1995

In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis.

artículo científico publicado en 2016

In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.

artículo científico publicado en 2011

Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

artículo científico publicado en 2017

Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor

artículo científico publicado en 2009

Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235

artículo científico publicado en 2012

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

artículo científico publicado en 2007

Location, location, location-makes all the difference for hypoxia in lung tumors.

artículo científico publicado en 2010

Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

artículo científico

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

artículo científico publicado en 2010

PERK-ing up autophagy during MYC-induced tumorigenesis.

artículo científico publicado en 2013

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

artículo científico publicado en 2006

Piling up the JNK: drug synergy through ER stress.

artículo científico publicado en 2009

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

artículo científico publicado en 2008

Radiation Mitigating Properties of Intranasally Administered KL4 Surfactant in a Murine Model of Radiation-Induced Lung Damage.

artículo científico publicado en 2017

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

artículo científico publicado en 2001

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

artículo científico publicado en 2002

Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo

artículo científico publicado en 2004

Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor

artículo científico publicado en 2011

Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

artículo científico publicado en 2015

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

artículo científico publicado en 2016

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.

artículo científico publicado en 2017

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.

artículo científico publicado en 2016

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

artículo científico publicado en 2014

Targeting hypoxia tolerance in cancer

artículo científico publicado en 2004

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

artículo científico publicado en 1996

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

artículo científico publicado en 2010

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

artículo científico publicado en 2015

The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage.

artículo científico publicado en 2006

The cell biology of the unfolded protein response.

artículo científico publicado en 2011

The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.

artículo científico publicado en 2012

The heat shock proteins as targets for radiosensitization and chemosensitization in cancer ⬇️

artículo científico publicado el 15 de diciembre de 2011

The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24.

artículo científico publicado en 2010

The use of a reversible transcription inhibitor, DRB, to investigate the involvement of specific proteins in the ocular circadian system of Aplysia

scientific article published on 01 March 1996

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells

artículo científico publicado en 2010

Transformed Cells Require Continuous Activity Of RNA Polymerase II To Resist Oncogene-Induced Apoptosis ⬇️

artículo científico publicado el 1 de diciembre de 1997

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

artículo científico publicado en 2015

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

artículo científico publicado en 2020

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

artículo científico publicado en 2016

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

artículo científico publicado en 2012

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

artículo científico publicado en 2016

p27Kip1 is essential for the antiproliferative action of 1,25-dihydroxyvitamin D3 in primary, but not immortalized, mouse embryonic fibroblasts.

artículo científico publicado en 2002

Lista de obras de Costas Koumenis

"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

Activating transcription factor 4 is translationally regulated by hypoxic stress

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Avoiding antiperspirants during breast radiation therapy: Myth or sound advice?

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

Control of the hypoxic response through regulation of mRNA translation.

Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.

Current Delivery Limitations of Proton PBS for FLASH

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

Development of a stress response therapy targeting aggressive prostate cancer.

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia.

ER stress, hypoxia tolerance and tumor progression.

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

Effects of radiation quality and oxygen on clustered DNA lesions and cell death.

Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia.

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

Evaluation of On- and Off-Line Bioluminescence Tomography System for Focal Irradiation Guidance. ⬇️

Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

HIF and MIF--a nifty way to delay senescence?

HIF-1alpha and p53: the ODD couple?

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab.

Hypoxia and the unfolded protein response.

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library

Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.

Identification of three proteins in the eye of Aplysia, whose synthesis is altered by serotonin (5-HT). Possible involvement of these proteins in the ocular circadian system

In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis.

In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.

Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor

Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

Location, location, location-makes all the difference for hypoxia in lung tumors.

Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

PERK-ing up autophagy during MYC-induced tumorigenesis.

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

Piling up the JNK: drug synergy through ER stress.

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

Radiation Mitigating Properties of Intranasally Administered KL4 Surfactant in a Murine Model of Radiation-Induced Lung Damage.

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo

Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor

Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

Targeting hypoxia tolerance in cancer

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage.

The cell biology of the unfolded protein response.

The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.

The heat shock proteins as targets for radiosensitization and chemosensitization in cancer ⬇️

The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24.

The use of a reversible transcription inhibitor, DRB, to investigate the involvement of specific proteins in the ocular circadian system of Aplysia

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells

Transformed Cells Require Continuous Activity Of RNA Polymerase II To Resist Oncogene-Induced Apoptosis ⬇️

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

p27Kip1 is essential for the antiproliferative action of 1,25-dihydroxyvitamin D3 in primary, but not immortalized, mouse embryonic fibroblasts.