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Lista de obras de Ian J Stratford

17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response.

artículo científico publicado en 2002

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo

artículo científico publicado en 1997

2-Nitroimidazole dual-function bioreductive drugs: studies on the effects of regioisomerism and side-chain structural modifications on differential cytotoxicity and radiosensitization by aziridinyl and oxiranyl derivatives

artículo científico publicado el 18 de septiembre de 1992

3-Nitro-1,2,4-triazoles as hypoxia-selective agents.

artículo científico publicado en 1989

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.

artículo científico publicado en 2003

31P MRS to monitor the induction of tumor hypoxia by the modification of the oxygen affinity of hemoglobin using BW 589C

artículo científico publicado en 1994

5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro

artículo científico publicado el 1 de marzo de 1998

A biochemical assessment of the neurotoxicity of the radiosensitizing drug misonidazole in the rat.

artículo científico publicado en 1981

A biochemical method for assessing the neurotoxic effects of misonidazole in the rat

artículo científico publicado en 1980

A biochemical neurotoxicity study relating the neurotoxic potential of metronidazole and nitrofurantoin with misonidazole

scientific article published on 01 March 1982

A comparison of adriamycin and mAMSA in vitro: cell lethality and SCE studies

artículo científico publicado en 1981

A comparison of adriamycin and mAMSA. II. Studies with V79 and human tumour multicellular spheroids.

artículo científico publicado en 1987

A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour

artículo científico publicado en 1996

A metabolite of the 2-nitroimidazole misonidazole with radiosensitizing properties

artículo científico publicado en 1978

A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs

artículo científico publicado en 2004

A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

artículo científico publicado en 2014

A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis

artículo científico publicado en 2002

A similarity model for the human angiogenic factor, thymidine phosphorylase/platelet derived-endothelial cell growth factor

artículo científico publicado en 1999

A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions

artículo científico publicado en 1994

A synthetic approach to novel carvotacetone and antheminone analogues with anti-tumour activity.

artículo científico publicado en 2013

Abnormal radiosensitizing and cytotoxic properties of ortho-substituted nitroimidazoles

scientific article published on 01 January 1983

Abstract 3042: The novel Akt inhibitor AZD5363 following radiotherapy improves tumor control in mouse models of head and neck cancer

Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer

artículo científico publicado en 2013

Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade

artículo científico publicado en 2014

Akt inhibition improves long-term tumour control following radiotherapy by altering the microenvironment

artículo científico publicado en 2017

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

artículo científico publicado en 2005

Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

artículo científico publicado en 2006

Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo

artículo científico publicado en 1986

Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours.

artículo científico publicado en 2002

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

artículo científico publicado en 2004

Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

scientific article published on 21 August 2007

Assessment of a range of novel nitro-aromatic radiosensitizers and bioreductive drugs

artículo científico publicado el 1 de enero de 1992

Aziridinyl nitropyrroles and nitropyrazoles as hypoxia-selective cytotoxins and radiosensitizers.

artículo científico publicado en 1991

Binding and Internalization in Receptor-Targeted Carriers: The Complex Role of CD44 in the Uptake of Hyaluronic Acid-Based Nanoparticles (siRNA Delivery)

artículo científico publicado en 2019

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships

artículo científico publicado en 1999

Bioreductive and gene therapy approaches to hypoxic diseases

artículo científico publicado en 2001

Bioreductive drugs and the selective induction of tumour hypoxia

artículo científico publicado en 1990

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

artículo científico publicado el 1 de enero de 1992

Bioreductive drugs for cancer therapy: the search for tumor specificity

artículo científico publicado en 1994

Bioreductive drugs into the next millennium

artículo científico publicado el 1 de septiembre de 1998

Can 31P magnetic resonance spectroscopy measurements of changes in experimental tumour metabolism be related to modification of oxygenation status?

artículo científico publicado el 1 de enero de 1992

Cancer chemotherapy and drug metabolism.

artículo científico publicado en 2005

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1.

artículo científico publicado en 1996

Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs

artículo científico publicado en 1996

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

artículo científico publicado en 2007

Chemopotentiation by CB 1954: the importance of postincubations and the possible involvement of poly(ADP-ribosylation)

artículo científico publicado en 1984

Chemosensitization by monofunctional alkylating agents

artículo científico publicado en 1986

Chemosensitization in vitro: potentiation of melphalan toxicity by misonidazole, metronidazole and nitrofurazone

scientific article published on 01 March 1982

Chirality of a 1,10-bisacetoxymitosene compound. Impact on reductive activation, DNA interstrand cross-linking and antitumour activity.

artículo científico publicado en 1996

Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery

artículo científico publicado en 2017

Clinical development of new drug-radiotherapy combinations ⬇️

artículo científico publicado en 2016

Combination of photodynamic therapy (PDT) and melphalan in experimental tumors.

artículo científico publicado en 1994

Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro

artículo científico publicado en 1980

Combining bioreductive drugs and radiation for the treatment of solid tumors.

artículo científico publicado en 2003

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

artículo científico publicado en 2007

Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT)

artículo científico publicado en 1994

Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model

artículo científico publicado en 2007

Construction and characterization of multiple human colon cancer cell lines for inducibly regulated gene expression.

artículo científico publicado en 2005

Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.

artículo científico publicado en 2009

Corrigendum to “Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands” [Canc. Lett. 403 (2017) 98–107] ⬇️

scientific article published on 19 June 2018

Corrigendum: Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome

artículo científico publicado en 2017

Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.

artículo científico publicado en 2007

Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

artículo científico publicado en 1994

Cyclopropamitosenes: novel bioreductive anticancer agents--mechanism of action and enzymic reduction

artículo científico publicado en 1994

Cytotoxic properties of a 4-nitroimidazole (NSC 38087): a radiosensitizer of hypoxic cells in vitro

artículo científico publicado en 1981

Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro

artículo científico publicado en 1980

Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation.

artículo científico publicado en 2004

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions

artículo científico publicado en 1990

Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase.

artículo científico publicado en 2007

Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells

artículo científico publicado en 1996

Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites ⬇️

artículo científico publicado el 1 de junio de 1993

Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.

artículo científico publicado en 2004

Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2)

artículo científico publicado en 2019

Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1)

scientific article published on 15 September 2008

Does reductive metabolism predict response to tirapazamine (SR 4233) in human non-small-cell lung cancer cell lines?

artículo científico publicado en 1999

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908) ⬇️

artículo científico publicado el 1 de enero de 1992

Dual induction of the Epo-Egr-TNF-alpha- plasmid in hypoxic human colon adenocarcinoma produces tumor growth delay.

artículo científico publicado en 2003

Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells.

artículo científico publicado en 2005

Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas

artículo científico publicado en 1990

Dual-function radiation sensitizers and bioreductive drugs: factors affecting cellular uptake and sensitizing efficiency in analogues of RSU 1069

scientific article published on 01 April 1988

Effect of hydralazine in spontaneous tumours assessed by oxygen electrodes and 31P-magnetic resonance spectroscopy

artículo científico publicado en 1996

Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro ⬇️

artículo científico publicado el 1 de marzo de 1977

Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N).

artículo científico publicado en 2009

Effects of some hypoxic cell radiosensitizers on the decay of potentially lethal oxygen-dependent damage in fully hydrated spores ⬇️

artículo científico publicado el 1 de junio de 1978

Electron-affinic sensitization VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. 1976.

artículo científico publicado en 2012

Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers

scientific article published on 01 July 1976

Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy

artículo científico

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

artículo científico publicado en 2005

Enhancement of bioreductive drug toxicity in murine tumours by inhibition of the activity of nitric oxide synthase ⬇️

artículo científico publicado el 1 de enero de 1997

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

artículo científico publicado en 2000

Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents

artículo científico publicado en 1989

Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron-affinity relationship

artículo científico publicado en 1982

Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air

artículo científico publicado en 1982

Enzymology of the reduction of the novel fused pyrazine mono-n-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase

scientific article published on 01 March 1996

Enzymology of tirapazamine metabolism: a review

artículo científico publicado el 1 de septiembre de 1998

Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44

artículo científico publicado en 2019

Evaluation of analogues of furan-amidines as inhibitors of NQO2.

artículo científico publicado en 2018

Evaluation of novel radiation sensitizers in vitro and in vivo.

artículo científico publicado en 1982

Evaluation of the alkaline comet assay and urinary 3-methyladenine excretion for monitoring DNA damage in melanoma patients treated with dacarbazine and tamoxifen

scientific article published on 01 January 2000

Evidence for a non-thermal effect of ultrasound.

artículo científico publicado en 1982

Exogenous and endogenous markers of tumour oxygenation status: definitive markers of tumour hypoxia?

artículo científico publicado en 2005

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.

artículo científico publicado en 2017

Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix.

artículo científico publicado en 2005

Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome

artículo científico publicado en 2007

Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man

artículo científico publicado en 1994

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

scientific article published on 01 January 1994

Fused pyrazine mono-N-oxides as bioreductive drugs. III. Characterization of RB 90740 in vitro and in vivo.

artículo científico publicado en 1995

GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding.

artículo científico publicado en 2003

Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth

artículo científico publicado en 2010

Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix

artículo científico publicado en 2001

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

scientific article published on 19 July 2011

Guidelines for the welfare and use of animals in cancer research

artículo científico publicado en 2010

HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells

artículo científico publicado en 2007

Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor

artículo científico publicado en 1999

Heterocyclic mono-N-oxides with potential applications as bioreductive anti-tumour drugs: Part 1. 8-Alkylamino-substituted phenylimidazo [1,2-a] quinoxalines

scientific article published on 01 December 1993

High efficiency of ferricenium salts as radiosensitizers of V79 cells in vitro and the KHT tumor in vivo

scientific article published on 01 April 1989

High uptake of RSU 1069 and its analogues melanotic melanomas

artículo científico publicado en 1989

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin

scientific article published on 10 December 2019

Hypoxia and oxidative stress. Tumour hypoxia--therapeutic considerations

artículo científico publicado en 2001

Hypoxia in tumors: molecular targets for anti-cancer therapeutics.

artículo científico publicado en 2004

Hypoxia response elements

artículo científico publicado en 1997

Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure

artículo científico publicado en 2004

Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.

artículo científico publicado en 2004

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

artículo científico publicado en 1997

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

scientific article published on April 2004

Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview

artículo científico publicado en 1986

Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived xenog

artículo científico

Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor

artículo científico publicado en 2008

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

artículo científico publicado en 2003

Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.

artículo científico publicado en 2010

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

artículo científico publicado en 1995

In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF- B Signaling

artículo científico publicado en 2012

In silico identification and biochemical characterization of novel inhibitors of NQO1

artículo científico publicado en 2006

In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

artículo científico publicado en 2010

In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts: effects of blood flow modification

artículo científico publicado en 1991

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

artículo científico publicado en 2009

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

artículo científico publicado en 1995

Increasing the effect of photodynamic therapy on the RIF-1 murine sarcoma, using the bioreductive drugs RSU1069 and RB6145 ⬇️

artículo científico publicado el 1 de diciembre de 1992

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

artículo científico publicado en 1998

Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine

artículo científico publicado en 1994

Induction of hypoxia in normal and malignant tissues by changing the oxygen affinity of hemoglobin--implications for therapy

artículo científico publicado en 1986

Induction of hypoxia in the KHT sarcoma by tumour necrosis factor and flavone acetic acid

artículo científico publicado en 1991

Induction of severe tumor hypoxia by modifiers of the oxygen affinity of hemoglobin

artículo científico publicado en 1989

Induction of tumour hypoxia by FAA and TNF: interaction with bioreductive drugs

artículo científico publicado en 1991

Induction of tumour hypoxia by a vasoactive agent. A combined NMR and radiobiological study

artículo científico publicado en 1989

Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo

scientific article published on 01 March 1989

Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.

artículo científico publicado en 2011

Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cellsin vitro

article

Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

artículo científico publicado en 2014

Inhibition of vascular endothelial growth factor signalling using cediranib (RECENTIN; AZD2171) enhances radiation response and causes substantial physiological changes in lung tumour xenografts

artículo científico publicado en 2008

Inhibitors of NQO1: identification of compounds more potent than dicoumarol without associated off-target effects.

artículo científico publicado en 2010

Insoluble derivatives of polynucleotide-phosphorylase

artículo científico publicado en 1973

Interaction of the cytotoxic and sensitizing effects of electron-affinic drugs and hyperthermia

artículo científico publicado en 1982

Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy

artículo científico publicado en 2016

Investigation of radiosensitivity gene signatures in cancer cell lines.

artículo científico publicado en 2014

Keynote address: Concepts and developments in radiosensitization of mammalian cells ⬇️

artículo científico publicado el 1 de enero de 1992

Magnetic resonance spectroscopic studies on 'real-time' changes in RIF-1 tumour metabolism and blood flow during and after photodynamic therapy

artículo científico publicado en 1994

Magnetic resonance spectroscopy studies on experimental murine and human tumors: Comparison of changes in phosphorus metabolism with induced changes in vascular volume ⬇️

artículo científico publicado el 1 de enero de 1992

Mammalian cell toxicity of nitro compounds : dependence upon reduction potential

artículo científico publicado en 1976

Manipulation and exploitation of the tumour environment for therapeutic benefit.

artículo científico publicado en 1994

Manipulation of radiobiological hypoxia in a human melanoma xenograft to exploit the bioreductive cytotoxicity of RSU-1069

artículo científico publicado en 1989

Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage

artículo científico publicado en 1987

Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway

artículo científico publicado en 2002

Metabolic profiling of hypoxia-inducible factor-1β-deficient and wild type Hepa-1 cells: effects of hypoxia measured by 1H magnetic resonance spectroscopy

Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability.

artículo científico publicado en 1993

Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine.

artículo científico publicado en 1994

Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting

artículo científico publicado en 2005

Monitoring metabolic responses after induction of hypoxia in the KHT tumour using 31P NMR spectroscopy

artículo científico publicado en 1991

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

artículo científico publicado en 2017

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line

artículo científico publicado en 2000

Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1)

artículo científico publicado en 2019

Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents

artículo científico publicado en 1999

Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs

scientific article published on 01 January 1991

No relationship between thymidine phosphorylase (TP, PD-ECGF) expression and hypoxia in carcinoma of the cervix

artículo científico publicado en 2006

Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro

artículo científico publicado en 2003

Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria

artículo científico publicado en 2016

Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones

artículo científico publicado en 2011

Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice

artículo científico publicado en 1991

Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved.

artículo científico publicado en 2007

Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours

artículo científico publicado en 2002

PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.

artículo científico publicado en 2008

Pharmacokinetics, metabolism and distribution of 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-A] pyrido [3,2-E] pyrazine-5-oxide in C3H mice.

artículo científico publicado en 1994

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

artículo científico publicado en 2004

Platelet-derived endothelial cell growth factor thymidine phosphorylase in tumour growth and response to therapy ⬇️

artículo científico publicado el 1 de enero de 1997

Potential antitumour mitosenes: relationship between in vitro DNA interstrand cross-link formation and DNA damage in Escherichia coli K-12 strains

artículo científico publicado en 1994

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

artículo científico publicado en 2003

Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine

artículo científico publicado en 1988

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands ⬇️

artículo científico publicado en 2017

Preincubation with electron affinic radiosensitizers followed by hyperthermia or X rays

artículo científico publicado en 1982

Pretreatment apoptosis in carcinoma of the cervix correlates with changes in tumour oxygenation during radiotherapy

artículo científico publicado en 2000

Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones

artículo científico publicado en 1999

Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection; results of EORTC Translational Research Fund studies

artículo científico publicado en 2004

Protection against misonidazole-induced neuropathy in rats: a biochemical assessment.

artículo científico publicado en 1983

Protection of pig epidermis against radiation-induced damage by the infusion of BW12C.

artículo científico publicado en 1991

Quinone bioreductive prodrugs as delivery agents

artículo científico publicado en 2004

RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo

scientific article published on 01 September 1984

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions

scientific article published on 01 January 1986

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

artículo científico publicado en 2016

Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo

artículo científico publicado en 1984

Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity

artículo científico publicado en 1994

Radiosensitization by the 2,4-dinitro-5-aziridinyl benzamide CB 1954: a structure/activity study

artículo científico publicado en 1987

Radiosensitization in vivo: a study with an homologous series of 2-nitroimidazoles

scientific article published on 01 October 1983

Radiosensitization of hypoxic mammalian cells in vitro by some 5-substituted-4-nitroimidazoles

scientific article published on 01 August 1981

Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands

artículo científico publicado en 1984

Radiosensitizers of hypoxic mammalian cells. 1-(Hydroxyaminoalkyl)-substituted nitroimidazoles

Radiosensitizing and Cytotoxicity Studies with CB 1954 (2,4-Dinitro-5-Aziridinylbenzamide)

artículo científico publicado el 1 de diciembre de 1981

Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase

artículo científico publicado en 1989

Radiotherapy Research Priorities for the UK

artículo científico publicado en 2010

Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer

artículo científico publicado en 2008

Reduction of tumour intracellular pH and enhancement of melphalan cytotoxicity by the ionophore Nigericin

artículo científico publicado en 1995

Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines

artículo científico publicado en 1995

Relationship between intracellular concentration and radiosensitizing effect of pimonidazole and etanidazole on two human melanoma cell lines

artículo científico publicado en 1993

Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole

artículo científico publicado en 1993

Relationship between topoisomerase II levels and resistance to topoisomerase II inhibitors in lung cancer cell lines.

artículo científico publicado en 1996

Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor.

artículo científico publicado en 2002

Reversal of P-glycoprotein-mediated multidrug resistance by pure anti-oestrogens and novel tamoxifen derivatives

artículo científico publicado en 1994

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.

artículo científico publicado en 2005

Role of thymidine phosphorylase in an in vitro model of human bladder cancer invasion

artículo científico publicado en 2002

S-2-amino-5-(2-nitroimidazol-1-yl)pentanoic acid: a model for potential bioreductively activated prodrugs for inhibitors of nitric oxide synthase (NOS) activity

scientific article published on 01 January 1997

S-2-amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS).

artículo científico publicado en 1998

Selective reversal of vinblastine resistance in multidrug-resistant cell lines by tamoxifen, toremifene and their metabolites.

artículo científico publicado en 1993

Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.

artículo científico publicado en 1994

Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice

artículo científico publicado en 2010

Spectrophotometric analysis of nucleic acids: oxygenation-dependent hyperchromism of DNA.

artículo científico publicado en 2010

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

scientific article published in Scientific Reports

Structure-activity relationships in the development of hypoxic cell radiosensitizers. I. Sensitization efficiency

artículo científico publicado en 1979

Structure-activity relationships in the development of hypoxic cell radiosensitizers. II. Cytotoxicity and therapeutic ratio

artículo científico publicado en 1979

Structure-activity relationships in the development of hypoxic cell radiosensitizers. III. Effects of basic substituents in nitroimidazole sidechains

artículo científico publicado en 1980

Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues

scientific article published on 01 July 1986

Subharmonic emission as an indicator of ultrasonically-induced biological damage

scientific article published on 01 November 1983

Synthesis and biological activity of thiazolylindolequinones, analogues of the natural product BE 10988.

artículo científico publicado en 1995

Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1)

artículo científico publicado en 2009

Synthesis and cytotoxic activity of indolyl thiazoles ⬇️

artículo científico publicado el 1 de junio de 1997

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

artículo científico publicado en 2002

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase

artículo científico publicado en 2004

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively ac

scientific article published on 01 September 1990

Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins

artículo científico publicado en 1990

Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase.

artículo científico publicado en 2003

Synthesis of a series of nitrothiophenes with basic or electrophilic substituents and evaluation as radiosensitizers and as bioreductively activated cytotoxins

artículo científico publicado en 1991

Synthesis of the enantiomers of the bioreductively-activated cytotoxin RSU-1069 and its prodrug RB6145 and lack of stereoselectivity in their cytotoxicity and radiosensitization in vitro

scientific article published on 01 January 1993

Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma

artículo científico publicado en 2012

Targeting gene expression to hypoxic tumor cells

article

Targeting gene therapy to cancer: a review

artículo científico publicado el 1 de enero de 1997

Targeting hypoxia with a new generation of indolequinones

artículo científico publicado el 1 de septiembre de 1998

Testing for hypoxia in forearm skin of patients with systemic sclerosis, assessed by pimonidazole.

artículo científico publicado en 2010

The CD44-Mediated Uptake of Hyaluronic Acid-Based Carriers in Macrophages.

artículo científico publicado en 2016

The anti-tumor immune response generated by radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade

The bioreductive agent RH1 and gamma-irradiation both cause G2/M cell cycle phase arrest and polyploidy in a p53-mutated human breast cancer cell line

artículo científico publicado en 2004

The decay of potentially lethal oxygen-dependent damage in fully hydrated Bacillus megaterium spores exposed to pulsed electron irradiation

artículo científico publicado el 1 de noviembre de 1977

The development of some nitroimidazoles as hypoxic cell sensitizers

artículo científico publicado en 1980

The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action

artículo científico publicado en 1986

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay

artículo científico publicado en 1989

The effect of caffeine on the cytotoxicity of misonidazole and some other nitroheterocyclic compounds

artículo científico publicado en 1982

The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in Chinese hamster lung fibroblasts and human breast-cancer cells in vitro

artículo científico publicado en 1993

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation

artículo científico publicado en 1990

The experimental development of bioreductive drugs and their role in cancer therapy.

artículo científico publicado en 1993

The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy

artículo científico publicado en 2010

The impact of intracellular generation of nitric oxide on the radiation response of human tumor cells.

artículo científico publicado en 2009

The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines.

artículo científico publicado en 2004

The influence of elevated levels of platelet-derived endothelial cell growth factor/thymidine phosphorylase on tumourigenicity, tumour growth, and oxygenation

artículo científico publicado en 1998

The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo.

artículo científico publicado en 1997

The interaction between radiation and complexes of cis-Pt(II) and Rh(II): studies at the molecular and cellular level

scientific article published on 01 October 1985

The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report

artículo científico publicado en 1980

The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts

artículo científico publicado en 2009

The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy

artículo científico publicado en 1996

The radiation response of V79 and human tumour multicellular spheroids – cell survival and growth delay studies ⬇️

artículo científico publicado el 1 de agosto de 1984

The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor

artículo científico publicado en 1986

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

artículo científico publicado en 2000

The response of spontaneous and transplantable murine tumors to vasoactive agents measured by 31p magnetic resonance spectroscopy ⬇️

artículo científico publicado el 1 de enero de 1992

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

artículo científico publicado en 1994

The role of cavitation in the interaction of ultrasound with V79 Chinese hamster cells in vitro

artículo científico publicado en 1982

The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway

artículo científico publicado en 2005

The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

artículo científico publicado en 1992

The toxicity of the radiosensitizer misonidazole towards hypoxic cells in vitro: a model for mouse and man

artículo científico publicado el 1 de septiembre de 1978

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

artículo científico publicado en 2014

Thermotolerance in chinese hamster cells under oxic conditions after chronic culture under hypoxia ⬇️

artículo científico publicado el 1 de abril de 1981

Thiol reactive nitroimidazoles: radiosensitization studies in vitro and in vivo

artículo científico publicado en 1984

Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro ⬇️

artículo científico publicado el 1 de julio de 1998

Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline.

artículo científico publicado en 2003

Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination

artículo científico publicado en 2005

Toxicity of nitro compounds toward hypoxic mammalian cells in vitro: dependence on reduction potential

artículo científico publicado en 1980

Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2.

artículo científico publicado en 2009

Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix

article

Ultrasonic irradiation of mammalian cells in vitro at hyperthermic temperatures

artículo científico publicado en 1980

Use of metronidazole and other nitroimidazole drugs in cancer therapy

artículo científico publicado el 1 de septiembre de 1978

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy

artículo científico publicado en 2004

Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts

artículo científico publicado en 2003

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors

artículo científico publicado en 2008

ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model.

artículo científico publicado en 2002

ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity.

artículo científico publicado en 2004

iNOS as a therapeutic target for treatment of human tumors

artículo científico publicado en 2008

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