Lista de obras - Umesh R Desai - Dominio Público Uruguay

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

artículo científico publicado en 2004

6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells

artículo científico publicado en 2015

A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.

artículo científico publicado en 2017

A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins

artículo científico publicado en 2015

A capillary electrophoretic method for fingerprinting low molecular weight heparins.

artículo científico publicado en 2008

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules

artículo científico publicado en 2017

A nanosensor for ultrasensitive detection of oversulfated chondroitin sulfate contaminant in heparin

artículo científico publicado en 2014

A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids

artículo científico publicado en 2007

A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds.

artículo científico publicado en 2014

A synthetic glycosaminoglycan mimetic blocks HSV-1 infection in human iris stromal cells

artículo científico publicado en 2018

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding

scientific article published on 10 September 2019

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.

artículo científico publicado en 2016

Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants

artículo científico publicado en 2015

Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitors

artículo científico publicado en 2014

Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.

artículo científico publicado en 2016

An electrophoresis-based assay for glycosyltransferase activity

artículo científico publicado en 1992

An update on recent patents on thrombin inhibitors (2010 - 2013)

artículo científico publicado en 2014

Application of molecular connectivity and electro-topological indices in quantitative structure-activity analysis of pyrazole derivatives as inhibitors of factor Xa and thrombin.

artículo científico publicado en 2008

Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin.

artículo científico publicado en 2009

Characterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acids

artículo científico publicado en 2009

Chemical sulfation of small molecules—advances and challenges ⬇️

artículo científico publicado el 17 de abril de 2010

Chemoenzymatically prepared heparan sulfate containing rare 2-O-sulfonated glucuronic acid residues.

artículo científico publicado en 2015

Conformational analysis of sucrose octasulfate by high resolution nuclear magnetic resonance spectroscopy

artículo científico publicado en 1995

Crystal structures of influenza A virus matrix protein M1: variations on a theme

artículo científico publicado en 2014

Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modeling

artículo científico publicado en 2015

Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides

artículo científico publicado en 2014

Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa.

artículo científico publicado en 2011

Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses.

artículo científico publicado en 2002

Discovery methodology for the development of direct factor VIIa inhibitors.

artículo científico publicado en 2014

Discovery of Allosteric Modulators of Factor XIa by Targeting Hydrophobic Domains Adjacent to Its Heparin-Binding Site ⬇️

artículo científico publicado el 18 de marzo de 2013

Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8

artículo científico publicado en 2020

Discovery of novel sulfonated small molecules that inhibit vascular tube formation ⬇️

artículo científico publicado el 16 de abril de 2012

Dynamic affinity chromatography in the separation of sulfated lignins binding to thrombin.

artículo científico publicado en 2012

Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational Studies

artículo científico publicado en 2012

Enzyme immobilization offers a robust tool to scale up the production of longer, diverse, natural glycosaminoglycan oligosaccharides

artículo científico publicado en 2020

Exploring new non-sugar sulfated molecules as activators of antithrombin.

artículo científico publicado en 2003

First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa

artículo científico publicado en 2009

Glycosaminoglycan-protein interaction studies using fluorescence spectroscopy.

artículo científico publicado en 2015

Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesis and autophagy responses in models of type 1 diabetes.

artículo científico

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity

artículo científico publicado en 2021

Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

artículo científico publicado en 2009

Identification of the site of binding of sulfated, low molecular weight lignins on thrombin

artículo científico publicado en 2011

Immobilization alters heparin cleaving properties of heparinase I.

artículo científico publicado en 2017

Importance of lysine 125 for heparin binding and activation of antithrombin.

artículo científico publicado en 2002

Importance of tryptophan 49 of antithrombin in heparin binding and conformational activation.

artículo científico publicado en 2005

Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics

artículo científico publicado en 2018

Inhibition of Human Cytomegalovirus Entry into Host Cells Through a Pleiotropic Small Molecule

artículo científico publicado en 2020

Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.

artículo científico publicado en 2009

Interaction of designed sulfated flavanoids with antithrombin: lessons on the design of organic activators.

artículo científico publicado en 2002

Investigation of the heparin-thrombin interaction by dynamic force spectroscopy

artículo científico publicado en 2015

Linear polyalkylamines as fingerprinting agents in capillary electrophoresis of low-molecular-weight heparins and glycosaminoglycans.

artículo científico publicado en 2011

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

artículo científico publicado en 2018

Mechanism of Heparin Activation of Antithrombin: Evidence for an Induced-Fit Model of Allosteric Activation Involving Two Interaction Subsites ⬇️

artículo científico publicado el 15 de septiembre de 1998

Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

artículo científico publicado en 1998

Mechanism of poly(acrylic acid) acceleration of antithrombin inhibition of thrombin: implications for the design of novel heparin mimics.

artículo científico publicado en 2005

Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions

artículo científico publicado en 2016

New approaches for the preparation of hydrophobic heparin derivatives

artículo científico publicado en 1994

New steroid haptens for radioimmunoassay: synthesis of steroids substituted with thioether or ester linkages at the 2 alpha-position

artículo científico publicado en 1991

Novel heparin mimetics reveal cooperativity between exosite 2 and sodium-binding site of thrombin

artículo científico publicado en 2018

Novel low molecular weight lignins as potential anti-emphysema agents: In vitro triple inhibitory activity against elastase, oxidation and inflammation.

artículo científico publicado en 2012

On designing non-saccharide, allosteric activators of antithrombin.

artículo científico publicado en 2008

On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans ⬇️

artículo científico publicado el 24 de octubre de 2012

On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients

scientific article published on 28 May 2019

Perspective on computational simulations of glycosaminoglycans

artículo científico publicado en 2018

Plasmin regulation through allosteric, sulfated, small molecules.

artículo científico publicado en 2015

Polymeric fluorescent heparin as one-step FRET substrate of human heparanase

scientific article published on 28 October 2018

Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.

artículo científico publicado en 2012

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics.

artículo científico publicado en 2016

Preface. Glycosaminoglycans

artículo científico publicado en 2015

Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3- O -sulfated heparan sulfate

artículo científico publicado en 2020

Rapid and efficient microwave-assisted synthesis of highly sulfated organic scaffolds.

artículo científico publicado en 2007

Rational design of potent, small, synthetic allosteric inhibitors of thrombin

artículo científico publicado en 2011

Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders

artículo científico

Rigorous Analysis of Free Solution Glycosaminoglycan Dynamics Using Simple, New Tools

artículo científico publicado en 2020

Role of arginine 129 in heparin binding and activation of antithrombin

artículo científico publicado en 2000

Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.

artículo científico

Serpin-glycosaminoglycan interactions.

artículo científico

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

artículo científico publicado en 2015

Strategy for the sequence analysis of heparin

artículo científico publicado en 1995

Structural characterization of a serendipitously discovered bioactive macromolecule, lignin sulfate.

artículo científico publicado en 2005

Structure elucidation of a novel acidic tetrasaccharide and hexasaccharide derived from a chemically modified heparin

scientific article published on 01 March 1993

Studying glycosaminoglycan-protein interactions using capillary electrophoresis

artículo científico publicado en 2015

Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.

artículo científico publicado en 2014

Substrate specificity of the heparin lyases from Flavobacterium heparinum

scientific article published on 01 November 1993

Sulfated caffeic acid dehydropolymer attenuates elastase and cigarette smoke extract-induced emphysema in rats: sustained activity and a need of pulmonary delivery.

artículo científico publicado en 2014

Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.

artículo científico publicado en 2014

Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa

artículo científico publicado en 2013

Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.

artículo científico publicado en 2011

Sulfation Patterns Determine Cellular Internalization of Heparin-Like Polysaccharides ⬇️

artículo científico publicado el 27 de febrero de 2013

Synthesis of glycosaminoglycan mimetics through sulfation of polyphenols

artículo científico publicado en 2015

Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential.

artículo científico publicado en 2005

Synthetic, non-saccharide, glycosaminoglycan mimetics selectively target colon cancer stem cells.

artículo científico publicado en 2014

Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects

artículo científico publicado en 2014

The Compensatory G88R Change Is Essential in Restoring the Normal Functions of Influenza A/WSN/33 Virus Matrix Protein 1 with a Disrupted Nuclear Localization Signal ⬇️

artículo científico publicado el 17 de octubre de 2012

The Promise of Sulfated Synthetic Small Molecules as Modulators of Glycosaminoglycan Function ⬇️

artículo científico publicado el 1 de agosto de 2013

Toward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins

artículo científico publicado en 2014

Training the next generation of biomedical investigators in glycosciences

artículo científico publicado en 2016

Transforming growth factor-β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycans

artículo científico publicado en 2015

Understanding Dermatan Sulfate-Heparin Cofactor II Interaction through Virtual Library Screening

artículo científico publicado en 2010

Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate.

artículo científico publicado en 2007

Visualizing antithrombin-binding 3-O-sulfated heparan sulfate motifs on cell surfaces

artículo científico publicado en 2020

Lista de obras de Umesh R Desai

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells

A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.

A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins

A capillary electrophoretic method for fingerprinting low molecular weight heparins.

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules

A nanosensor for ultrasensitive detection of oversulfated chondroitin sulfate contaminant in heparin

A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids

A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds.

A synthetic glycosaminoglycan mimetic blocks HSV-1 infection in human iris stromal cells

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.

Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants

Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitors

Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.

An electrophoresis-based assay for glycosyltransferase activity

An update on recent patents on thrombin inhibitors (2010 - 2013)

Application of molecular connectivity and electro-topological indices in quantitative structure-activity analysis of pyrazole derivatives as inhibitors of factor Xa and thrombin.

Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin.

Characterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acids

Chemical sulfation of small molecules—advances and challenges ⬇️

Chemoenzymatically prepared heparan sulfate containing rare 2-O-sulfonated glucuronic acid residues.

Conformational analysis of sucrose octasulfate by high resolution nuclear magnetic resonance spectroscopy

Crystal structures of influenza A virus matrix protein M1: variations on a theme

Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modeling

Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides

Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa.

Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses.

Discovery methodology for the development of direct factor VIIa inhibitors.

Discovery of Allosteric Modulators of Factor XIa by Targeting Hydrophobic Domains Adjacent to Its Heparin-Binding Site ⬇️

Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8

Discovery of novel sulfonated small molecules that inhibit vascular tube formation ⬇️

Dynamic affinity chromatography in the separation of sulfated lignins binding to thrombin.

Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational Studies

Enzyme immobilization offers a robust tool to scale up the production of longer, diverse, natural glycosaminoglycan oligosaccharides

Exploring new non-sugar sulfated molecules as activators of antithrombin.

First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa

Glycosaminoglycan-protein interaction studies using fluorescence spectroscopy.

Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesis and autophagy responses in models of type 1 diabetes.

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity

Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

Identification of the site of binding of sulfated, low molecular weight lignins on thrombin

Immobilization alters heparin cleaving properties of heparinase I.

Importance of lysine 125 for heparin binding and activation of antithrombin.

Importance of tryptophan 49 of antithrombin in heparin binding and conformational activation.

Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics

Inhibition of Human Cytomegalovirus Entry into Host Cells Through a Pleiotropic Small Molecule

Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.

Interaction of designed sulfated flavanoids with antithrombin: lessons on the design of organic activators.

Investigation of the heparin-thrombin interaction by dynamic force spectroscopy

Linear polyalkylamines as fingerprinting agents in capillary electrophoresis of low-molecular-weight heparins and glycosaminoglycans.

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

Mechanism of Heparin Activation of Antithrombin: Evidence for an Induced-Fit Model of Allosteric Activation Involving Two Interaction Subsites ⬇️

Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

Mechanism of poly(acrylic acid) acceleration of antithrombin inhibition of thrombin: implications for the design of novel heparin mimics.

Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions

New approaches for the preparation of hydrophobic heparin derivatives

New steroid haptens for radioimmunoassay: synthesis of steroids substituted with thioether or ester linkages at the 2 alpha-position

Novel heparin mimetics reveal cooperativity between exosite 2 and sodium-binding site of thrombin

Novel low molecular weight lignins as potential anti-emphysema agents: In vitro triple inhibitory activity against elastase, oxidation and inflammation.

On designing non-saccharide, allosteric activators of antithrombin.

On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans ⬇️

On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients

Perspective on computational simulations of glycosaminoglycans

Plasmin regulation through allosteric, sulfated, small molecules.

Polymeric fluorescent heparin as one-step FRET substrate of human heparanase

Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics.

Preface. Glycosaminoglycans

Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3- O -sulfated heparan sulfate

Rapid and efficient microwave-assisted synthesis of highly sulfated organic scaffolds.

Rational design of potent, small, synthetic allosteric inhibitors of thrombin

Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders

Rigorous Analysis of Free Solution Glycosaminoglycan Dynamics Using Simple, New Tools

Role of arginine 129 in heparin binding and activation of antithrombin

Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.

Serpin-glycosaminoglycan interactions.

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

Strategy for the sequence analysis of heparin