Lista de obras - Marcus Conrad - Dominio Público Uruguay

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

artículo científico publicado en 2010

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

artículo científico publicado en 2016

A cozy niche in an iron world

scientific article published on 04 November 2020

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

artículo científico publicado en 2016

ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling

artículo científico publicado en 2011

Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity

artículo científico publicado en 2010

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

artículo científico publicado en 2017

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance

article

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

artículo científico publicado en 2010

Broken hearts: Iron overload, ferroptosis and cardiomyopathy

scientific article published on 01 April 2019

Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation

artículo científico publicado en 2015

Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons

scientific article published on 06 March 2014

Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice

artículo científico publicado en 2013

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

artículo científico publicado en 2017

Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function

artículo científico publicado en 2015

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.

artículo científico publicado en 2011

Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development

scientific journal article

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

artículo científico publicado en 2013

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

artículo científico publicado en 2010

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

artículo científico publicado en 2021

Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase

artículo científico publicado en 2006

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE

scientific article published on 17 December 2018

Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium

artículo científico publicado en 2016

EpCAM is involved in maintenance of the murine embryonic stem cell phenotype

artículo científico publicado en 2009

Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice

artículo científico publicado en 2012

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

artículo científico publicado en 2004

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

artículo científico publicado en 2017

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

artículo científico publicado en 2015

Ferroptosis Inhibition: Mechanisms and Opportunities

artículo científico publicado en 2017

Ferroptosis and necroinflammation, a yet poorly explored link

scientific article published on 06 August 2018

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

scientific article published on 01 July 2019

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

artículo científico publicado en 2017

Ferroptosis: the Good, the Bad and the Ugly

scientific article published on 04 November 2020

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

artículo científico publicado en 2017

Glutathione Peroxidase 4 and Ferroptosis

Glutathione Peroxidases

Glutathione and thioredoxin dependent systems in neurodegenerative disease: what can be learned from reverse genetics in mice

artículo científico publicado en 2013

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

artículo científico publicado en 2015

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

artículo científico publicado en 2016

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

artículo científico publicado en 2008

Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.

scientific article published on 25 March 2011

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

artículo científico publicado en 2015

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

artículo científico publicado en 2015

In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model

artículo científico publicado en 2021

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

artículo científico publicado en 2014

Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration

artículo científico publicado en 2014

Iron and ferroptosis: A still ill-defined liaison

artículo científico publicado en 2017

Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis

artículo científico publicado en 2015

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation

artículo científico publicado en 2012

Lipoxygenases-Killers against Their Will?

artículo científico publicado en 2018

Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation

artículo científico publicado en 2010

Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection

artículo científico publicado en 2011

Mitochondrial and cytosolic thioredoxin reductase knockout mice

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

artículo científico publicado en 2009

Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion.

artículo científico publicado en 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

artículo científico publicado en 2018

Mouse Models for Glutathione Peroxidase 4 (GPx4)

Mouse Models that Target Individual Selenoproteins

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

artículo científico publicado en 2011

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

scholarly article by Behrouz Hassannia et al published 1 August 2018 in Journal of Clinical Investigation

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

scientific journal article

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4.

artículo científico publicado en 2018

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

artículo científico publicado en 2017

Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate

article

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

artículo científico publicado en 2016

Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.

artículo científico publicado en 2018

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

artículo científico publicado en 2014

Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals

artículo científico publicado en 2007

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

artículo científico publicado en 2013

Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages

artículo científico publicado en 2011

Publisher Correction: The chemical basis of ferroptosis

artículo científico publicado en 2020

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe.

artículo científico publicado en 2018

ROS, thiols and thiol-regulating systems in male gametogenesis

artículo científico publicado en 2014

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

artículo científico publicado en 2011

Regulated necrosis: disease relevance and therapeutic opportunities

artículo científico publicado en 2016

Regulation of lipid peroxidation and ferroptosis in diverse species.

artículo científico publicado en 2018

Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin

artículo científico publicado en 2010

Role of GPX4 in ferroptosis and its pharmacological implication

artículo científico publicado en 2018

Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation

artículo científico publicado en 2005

Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.

artículo científico publicado en 2014

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.

artículo científico publicado en 2013

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

artículo científico publicado en 2017

Selenium and GPX4, a vital symbiosis

artículo científico publicado en 2018

Selenium and iron, two elemental rivals in the ferroptotic death process.

artículo científico publicado en 2018

Selenoprotein Gene Nomenclature

artículo científico publicado en 2016

System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency

artículo científico publicado en 2010

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

artículo científico publicado en 2015

Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.

artículo científico publicado en 2013

Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx).

artículo científico publicado en 2003

The antioxidant requirement for plasma membrane repair in skeletal muscle

artículo científico publicado en 2015

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

artículo científico publicado en 2022

The chemical basis of ferroptosis

artículo científico publicado en 2019

The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells

artículo científico publicado en 2018

The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization

artículo científico publicado en 2012

The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.

artículo científico publicado en 2005

The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond

artículo científico publicado en 2011

The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes

artículo científico publicado en 2017

The role of thioredoxin reductases in brain development

artículo científico publicado en 2008

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.

artículo científico publicado en 2018

Thiol switches in mitochondria: operation and physiological relevance

artículo científico

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

artículo científico publicado en 2016

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.

artículo científico publicado en 2009

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

artículo científico publicado en 2016

Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies

artículo científico publicado en 2010

hIAPP forms toxic oligomers in plasma

article

Lista de obras de Marcus Conrad

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

A cozy niche in an iron world

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling

Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

Broken hearts: Iron overload, ferroptosis and cardiomyopathy

Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation

Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons

Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.

Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE

Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium

EpCAM is involved in maintenance of the murine embryonic stem cell phenotype

Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

Ferroptosis Inhibition: Mechanisms and Opportunities

Ferroptosis and necroinflammation, a yet poorly explored link

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Ferroptosis: the Good, the Bad and the Ugly

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

Glutathione Peroxidase 4 and Ferroptosis

Glutathione Peroxidases

Glutathione and thioredoxin dependent systems in neurodegenerative disease: what can be learned from reverse genetics in mice

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration

Iron and ferroptosis: A still ill-defined liaison

Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation

Lipoxygenases-Killers against Their Will?

Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation

Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection

Mitochondrial and cytosolic thioredoxin reductase knockout mice

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Mouse Models for Glutathione Peroxidase 4 (GPx4)

Mouse Models that Target Individual Selenoproteins

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4.

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages

Publisher Correction: The chemical basis of ferroptosis

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe.

ROS, thiols and thiol-regulating systems in male gametogenesis

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

Regulated necrosis: disease relevance and therapeutic opportunities

Regulation of lipid peroxidation and ferroptosis in diverse species.

Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin

Role of GPX4 in ferroptosis and its pharmacological implication

Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation