Lista de obras - Anthony B Pinkerton - Dominio Público Uruguay

6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors

scientific article published on 30 November 2010

A three-component coupling approach to cyclopentanoids.

artículo científico publicado en 2001

Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.

artículo científico publicado en 2015

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

scientific article published on 01 October 2018

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

artículo científico publicado en 2017

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

artículo científico publicado en 2015

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

artículo científico publicado en 2004

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.

artículo científico publicado en 2004

Arylmethylamino steroids as antiparasitic agents

artículo científico publicado en 2017

Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines

artículo científico publicado en 2015

Boosting NAD+ with a small molecule that activates NAMPT

scientific article published on 19 July 2019

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

artículo científico publicado en 2017

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

artículo científico publicado en 2017

Diaryl substituted pyrazoles as potent CCR2 receptor antagonists

artículo científico publicado en 2006

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor

artículo científico publicado en 2012

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

artículo científico publicado en 2017

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

artículo científico publicado en 2013

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

artículo científico publicado en 2015

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

artículo científico publicado en 2014

Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

artículo científico publicado en 2019

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.

artículo científico publicado en 2017

Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity

artículo científico publicado en 2014

Formation of vinyl halides via a ruthenium-catalyzed three-component coupling.

artículo científico publicado en 2002

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

artículo científico publicado en 2019

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter

artículo científico publicado en 2012

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

artículo científico publicado en 2017

High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

artículo científico publicado en 2012

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

scientific article published on 14 February 2019

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

artículo científico publicado en 2013

Imidazole-derived agonists for the neurotensin 1 receptor.

artículo científico publicado en 2013

Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI

scientific article published on 18 August 2018

Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.

artículo científico publicado en 2012

Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.

artículo científico publicado en 2013

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse

artículo científico publicado en 2016

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

artículo científico publicado en 2014

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

artículo científico publicado en 2017

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

artículo científico publicado en 2015

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

artículo científico publicado en 2015

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

artículo científico publicado en 2003

Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.

artículo científico

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

artículo científico publicado en 2018

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

artículo científico publicado en 2015

Serine-threonine kinase TAO3-mediated trafficking of endosomes containing the invadopodia scaffold TKS5α promotes cancer invasion and tumor growth

artículo científico publicado en 2021

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

artículo científico publicado en 2010

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

artículo científico publicado en 2017

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

scientific article published on 20 August 2019

Lista de obras de Anthony B Pinkerton

6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors

A three-component coupling approach to cyclopentanoids.

Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.

Arylmethylamino steroids as antiparasitic agents

Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines

Boosting NAD+ with a small molecule that activates NAMPT

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Diaryl substituted pyrazoles as potent CCR2 receptor antagonists

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.

Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity

Formation of vinyl halides via a ruthenium-catalyzed three-component coupling.

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

Imidazole-derived agonists for the neurotensin 1 receptor.

Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI

Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.

Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

Serine-threonine kinase TAO3-mediated trafficking of endosomes containing the invadopodia scaffold TKS5α promotes cancer invasion and tumor growth

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance