Lista de obras - Douglas R Cavener - Dominio Público Uruguay

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

artículo científico publicado en 2013

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

artículo científico publicado en 2000

A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster

artículo científico publicado en 1986

Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.

artículo científico publicado en 2016

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

scientific journal article

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

artículo científico publicado en 2009

An evolutionarily conserved palindrome in the Drosophila Gld promoter directs tissue-specific expression

artículo científico publicado en 1994

Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster

artículo científico publicado en 1983

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

artículo científico publicado en 2001

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

artículo científico publicado en 2012

Chronic granulomatous disease

artículo científico publicado en 1987

Coevolution of the glucose dehydrogenase gene and the ejaculatory duct in the genus Drosophila

artículo científico publicado en 1985

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

artículo científico publicado en 1987

Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene

artículo científico publicado en 2001

Correction: PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice.

artículo científico publicado en 2009

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2 ⬇️

artículo científico publicado el 6 de diciembre de 2010

Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling

artículo científico publicado en 2014

Eukaryotic start and stop translation sites.

artículo científico publicado en 1991

Evolution of Developmental Regulation

scientific article published in 1989

Evolution of the expression of the Gld gene in the reproductive tract of Drosophila ⬇️

artículo científico publicado el 1 de noviembre de 1992

Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi

artículo científico publicado en 2017

Expansion and evolution of insect GMC oxidoreductases

artículo científico publicado en 2007

GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.

artículo científico publicado en 2013

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

artículo científico publicado en 2009

GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis ⬇️

artículo científico publicado el 30 de julio de 2013

GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.

artículo científico publicado en 1992

Genetic connectivity and population structure of African savanna elephants (Loxodonta africana) in Tanzania

artículo científico publicado en 2020

Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.

artículo científico publicado en 2014

Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster

artículo científico publicado en 1980

Genomic DNA analysis of the estrogen receptor gene in breast cancer

artículo científico publicado en 1989

Giraffe genome sequence reveals clues to its unique morphology and physiology

artículo científico publicado en 2016

Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster

artículo científico publicado en 2004

Hyperthermia Induces the ER Stress Pathway ⬇️

artículo científico publicado el 18 de agosto de 2011

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

artículo científico publicado en 2013

Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2.

artículo científico publicado en 1994

Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2 beta.

artículo científico publicado en 1994

Isolation of genes encoding proteins of immunological importance

scientific article published on 01 January 1987

Isolation of the Gene Encoding the Drosophila melanogaster Homolog of the Saccharomyces cerevisiae GCN2 eIF-2α Kinase ⬇️

artículo científico publicado el 1 de julio de 1998

MULTIGENIC RESPONSE TO ETHANOL IN DROSOPHILA MELANOGASTER.

artículo científico publicado en 1981

Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.

artículo científico publicado en 1997

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.

artículo científico publicado en 2006

New ways of initiating translation in eukaryotes.

artículo científico publicado en 2001

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway ⬇️

artículo científico publicado en 2010

PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis

artículo científico publicado en 2006

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis

artículo científico publicado en 2006

PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility

artículo científico publicado en 2016

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

artículo científico publicado en 2007

PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver

scientific journal article

PERK in beta cell biology and insulin biogenesis

artículo científico publicado en 2010

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation

artículo científico publicado en 2008

PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.

artículo científico publicado en 2005

PERK regulates Gq protein-coupled intracellular Ca(2+) dynamics in primary cortical neurons

artículo científico publicado en 2016

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice

artículo científico publicado en 2009

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

scientific journal article

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions

artículo científico publicado en 2014

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

artículo científico publicado en 2003

Preference for ethanol in Drosophila melanogaster associated with the alcohol dehydrogenase polymorphism ⬇️

artículo científico publicado el 1 de septiembre de 1979

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

artículo científico publicado en 2004

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

artículo científico publicado en 2005

Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis

artículo científico publicado en 2008

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

artículo científico publicado en 2016

Response of theG6pd and6Pgd polymorphisms inDrosophila melanogaster to dietary selection

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice

scientific article published on 23 April 2020

Seeing spots: Quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

artículo científico publicado en 2017

Seeing spots: quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

artículo científico publicado en 2018

Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3.

artículo científico publicado en 2009

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits ⬇️

artículo científico publicado el 11 de agosto de 2013

The Developmental Genetic Basis of Organismal Evolution

artículo científico publicado en 1983

The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development

artículo científico publicado en 1992

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

artículo científico publicado en 2002

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid

artículo científico publicado en 2007

The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

artículo científico publicado en 2017

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

scientific journal article

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

artículo científico publicado en 2006

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

artículo científico publicado en 2014

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

artículo científico publicado en 2018

Transgenic animal studies on the evolution of genetic regulatory circuitries.

artículo científico publicado en 1992

Translational control and the unfolded protein response

artículo científico publicado en 2007

Tryptophan catabolism generates autoimmune-preventive regulatory T cells

artículo científico publicado en 2006

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

artículo científico publicado en 2005

Using spot pattern recognition to examine population biology, evolutionary ecology, sociality, and movements of giraffes: a 70-year retrospective

artículo científico publicado en 2022

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

artículo científico publicado en 2009

Lista de obras de Douglas R Cavener

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster

Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

An evolutionarily conserved palindrome in the Drosophila Gld promoter directs tissue-specific expression

Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

Chronic granulomatous disease

Coevolution of the glucose dehydrogenase gene and the ejaculatory duct in the genus Drosophila

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene

Correction: PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice.

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2 ⬇️

Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling

Eukaryotic start and stop translation sites.

Evolution of Developmental Regulation

Evolution of the expression of the Gld gene in the reproductive tract of Drosophila ⬇️

Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi

Expansion and evolution of insect GMC oxidoreductases

GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis ⬇️

GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.

Genetic connectivity and population structure of African savanna elephants (Loxodonta africana) in Tanzania

Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.

Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster

Genomic DNA analysis of the estrogen receptor gene in breast cancer

Giraffe genome sequence reveals clues to its unique morphology and physiology

Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster

Hyperthermia Induces the ER Stress Pathway ⬇️

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2.

Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2 beta.

Isolation of genes encoding proteins of immunological importance

Isolation of the Gene Encoding the Drosophila melanogaster Homolog of the Saccharomyces cerevisiae GCN2 eIF-2α Kinase ⬇️

MULTIGENIC RESPONSE TO ETHANOL IN DROSOPHILA MELANOGASTER.

Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.

New ways of initiating translation in eukaryotes.

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway ⬇️

PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis

PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver

PERK in beta cell biology and insulin biogenesis

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation

PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.

PERK regulates Gq protein-coupled intracellular Ca(2+) dynamics in primary cortical neurons

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

Preference for ethanol in Drosophila melanogaster associated with the alcohol dehydrogenase polymorphism ⬇️

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

Response of theG6pd and6Pgd polymorphisms inDrosophila melanogaster to dietary selection

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice

Seeing spots: Quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

Seeing spots: quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3.

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits ⬇️

The Developmental Genetic Basis of Organismal Evolution

The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid

The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Transgenic animal studies on the evolution of genetic regulatory circuitries.

Translational control and the unfolded protein response

Tryptophan catabolism generates autoimmune-preventive regulatory T cells