Lista de obras - Sumit Sahni - Dominio Público Uruguay

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

artículo científico publicado en 2016

A Unique Urinary Metabolomic Signature for the Detection of Pancreatic Ductal Adenocarcinoma

artículo científico publicado en 2020

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease

artículo científico publicado en 2017

Adenosine monophosphate-activated kinase and its key role in catabolism: structure, regulation, biological activity, and pharmacological activation

artículo científico publicado en 2014

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

artículo científico publicado en 2015

Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism.

artículo científico publicado en 2013

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

artículo científico publicado en 2016

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).

artículo científico publicado en 2015

Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance.

artículo científico publicado en 2011

Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.

artículo científico publicado en 2015

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

artículo científico publicado en 2017

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

artículo científico publicado en 2016

Gene of the month. AMP kinase (PRKAA1).

artículo científico publicado en 2014

Gene of the month: BECN1.

artículo científico

Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

artículo científico

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

artículo científico publicado en 2018

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

artículo científico publicado en 2015

Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.

artículo científico publicado en 2017

Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".

artículo científico publicado en 2016

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

artículo científico publicado en 2016

Making a case for albumin – a highly promising drug-delivery system.

artículo científico publicado en 2015

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

artículo científico publicado en 2016

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

artículo científico publicado en 2013

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

artículo científico publicado en 2013

NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis

artículo científico publicado en 2014

Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes

artículo científico publicado en 2018

Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron

artículo científico publicado en 2011

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

artículo científico publicado en 2015

Novel serum protein biomarker panel for early diagnosis of pancreatic cancer

artículo científico publicado en 2024

Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion

artículo científico publicado en 2015

P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.

scientific article published on 23 September 2013

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

artículo científico publicado en 2015

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

artículo científico publicado en 2016

Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

artículo científico publicado en 2017

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

artículo científico publicado en 2016

Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?

artículo científico publicado en 2020

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

artículo científico publicado en 2016

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

artículo científico publicado en 2016

The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells

artículo científico publicado en 2016

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

artículo científico publicado en 2015

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

artículo científico publicado en 2019

The mechanistic role of chemically diverse metal ions in the induction of autophagy

artículo científico publicado en 2017

The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

artículo científico publicado en 2014

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

artículo científico publicado en 2015

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

artículo científico publicado en 2015

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

artículo científico

The role of NDRG1 in the pathology and potential treatment of human cancers

artículo científico publicado en 2013

The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1

scientific article published on 03 December 2014

Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.

artículo científico publicado en 2018

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Sumit Sahni

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

A Unique Urinary Metabolomic Signature for the Detection of Pancreatic Ductal Adenocarcinoma

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease

Adenosine monophosphate-activated kinase and its key role in catabolism: structure, regulation, biological activity, and pharmacological activation

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism.

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).

Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance.

Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

Gene of the month. AMP kinase (PRKAA1).

Gene of the month: BECN1.

Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.

Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

Making a case for albumin – a highly promising drug-delivery system.

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis

Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes

Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

Novel serum protein biomarker panel for early diagnosis of pancreatic cancer

Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion

P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

The mechanistic role of chemically diverse metal ions in the induction of autophagy

The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

The role of NDRG1 in the pathology and potential treatment of human cancers

The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1

Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)