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Lista de obras de Carl Cotman

15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis

artículo científico publicado en 2001

A comparison of 2-amino-4-phosphonobutyric acid (AP4) receptors and [3H]AP4 binding sites in the rat brain

artículo científico publicado en 1986

A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog.

artículo científico publicado en 2005

A microfluidic culture platform for CNS axonal injury, regeneration and transport

artículo científico publicado en 2005

A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

artículo científico publicado en 2000

A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy

artículo científico publicado en 2015

A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap

artículo científico publicado en 2013

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

artículo científico publicado en 2013

Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease.

artículo científico publicado en 2003

Achieving and maintaining cognitive vitality with aging

artículo científico publicado en 2002

Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology

artículo científico publicado en 2001

Adaptive versus pathological plasticity. Possible contributions to age-related dementia

artículo científico publicado en 1993

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

artículo científico publicado en 2003

Adult and embryonic frontal cortex transplants after frontal cortex ablation enhance recovery on a reinforced alternation task

artículo científico publicado en 1986

Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs ⬇️

artículo científico publicado el 19 de febrero de 2011

Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production

artículo científico publicado en 2013

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease

artículo científico publicado en 1992

Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy

artículo científico publicado en 1990

Analysis of brain injury following intrahippocampal administration of beta-amyloid in streptozotocin-treated rats

artículo científico publicado en 1994

Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures

artículo científico publicado en 2012

Apolipoprotein-E genotyping of diabetic dementia patients: is diabetes rare in Alzheimer's disease?

artículo científico publicado en 1996

Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation

artículo científico publicado en 1991

Astrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusion

artículo científico publicado en 2001

Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice

artículo científico publicado en 2002

Axonal mRNA in uninjured and regenerating cortical mammalian axons

artículo científico publicado en 2009

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

artículo científico publicado en 2010

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

artículo científico publicado en 2010

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo ⬇️

artículo científico publicado el 24 de marzo de 1988

Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology

artículo científico publicado en 1997

Bcl-2 facilitates recovery from DNA damage after oxidative stress

artículo científico publicado en 1999

Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised

artículo científico publicado en 2001

Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine

artículo científico publicado en 1996

Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease

artículo científico publicado en 1993

Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome

artículo científico publicado en 2002

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

artículo científico publicado en 1996

Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats.

artículo científico publicado en 2005

Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.

artículo científico publicado en 2004

Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

artículo científico publicado en 1994

Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease

artículo científico publicado en 2014

Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site

artículo científico publicado en 1982

Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase ⬇️

artículo científico publicado el 5 de diciembre de 2012

Brainstem and cortical Lewy bodies in patients presenting clinically with Alzheimer's disease

artículo científico publicado en 2002

Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture.

artículo científico publicado en 1994

Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro

artículo científico publicado en 1995

Canine cognition, aging and neuropathology. Introduction

artículo científico publicado en 2000

Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy

artículo científico publicado en 1995

Carbachol increases intracellular free calcium in cultured rat microglia

artículo científico publicado en 1993

Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers.

artículo científico publicado en 2012

Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous.

artículo científico publicado en 2002

Caspase-3 activation as a bifurcation point between plasticity and cell death.

artículo científico publicado en 2012

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

artículo científico publicado en 2002

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

artículo científico publicado en 2004

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

article

Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain

artículo científico publicado en 2002

Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology

artículo científico publicado en 2005

Cations differentially affect subpopulations of L-glutamate receptors in rat synaptic plasma membranes

artículo científico publicado en 1985

Cell biology of synaptic plasticity

artículo científico publicado en 1984

Chloride ions enhance L-glutamate binding to rat brain synaptic membranes

artículo científico publicado en 1982

Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs

artículo científico publicado en 2005

Clinical and pathological evidence for a frontal variant of Alzheimer disease

artículo científico publicado en 1999

Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates

artículo científico publicado en 1993

Color image analysis in neuroanatomical research: application to senile plaque subtype quantification in Alzheimer's disease

artículo científico publicado en 1995

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

artículo científico publicado en 2003

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

artículo científico publicado en 2010

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

artículo científico publicado en 2011

Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome

artículo científico publicado en 2001

Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks

artículo científico publicado en 2004

Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex

artículo científico publicado en 1996

Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid

artículo científico publicado en 1993

Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia

artículo científico publicado en 1995

Cytokines and cytokine networks target neurons to modulate long-term potentiation

artículo científico publicado en 2017

DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia

artículo científico publicado en 2000

Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state

artículo científico publicado en 1994

Decreases in protease nexins in Alzheimer's disease brain

artículo científico publicado en 1995

Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease

artículo científico publicado en 1986

Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines.

artículo científico publicado en 2018

Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS-Cog-Exec

artículo científico publicado en 2020

Development of a protocol for studying object recognition memory in the dog.

artículo científico publicado en 2000

Dietary enrichment counteracts age-associated cognitive dysfunction in canines

artículo científico publicado en 2002

Differential regulation by beta-amyloid peptides of intracellular free Ca2+ concentration in cultured rat microglia

artículo científico publicado en 1995

Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains

artículo científico publicado en 2007

Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiography

artículo científico publicado en 1984

Distribution of basic fibroblast growth factor in the developing rat brain

artículo científico publicado en 1994

Early association of reactive astrocytes with senile plaques in Alzheimer's disease

artículo científico publicado en 1995

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine

artículo científico publicado en 2015

Effects of conditioning lesions on transplant survival, connectivity, and function. Role of neurotrophic factors

artículo científico publicado en 1987

Effects of entorhinal lesions on trophic activities present in rat entorhinal cortex and hippocampus as studied using primary cultures of entorhinal and septal tissues.

artículo científico publicado en 1987

Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men.

artículo científico publicado en 2005

Enhancing the self-repairing potential of the CNS after injury

artículo científico publicado en 1984

Estrogen regulates bcl-x expression in rat hippocampus

artículo científico publicado en 2001

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

artículo científico publicado en 2012

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

artículo científico publicado en 2008

Exercise builds brain health: key roles of growth factor cascades and inflammation

artículo científico publicado en 2007

Exercise enhances memory consolidation in the aging brain

artículo científico publicado en 2014

Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

artículo científico publicado en 2005

Exercise-induced gene expression changes in the rat spinal cord.

artículo científico publicado en 2005

Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5.

artículo científico publicado en 1996

Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures

artículo científico publicado en 2000

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study ⬇️

artículo científico publicado el 23 de julio de 2012

External force-assisted cell positioning inside microfluidic devices

artículo científico publicado en 2007

Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons

artículo científico publicado en 2007

Factors affecting innervation in the CNS: comparison of three cholinergic cell types transplanted to the hippocampus of adult rats

artículo científico publicado en 1986

Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death ⬇️

artículo científico publicado el 1 de abril de 2003

Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide

artículo científico publicado en 2000

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

artículo científico publicado en 2007

Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders

artículo científico publicado en 2019

Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging.

artículo científico publicado en 2004

GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro

artículo científico publicado en 1998

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

artículo científico publicado en 2020

Gene expression changes in the course of normal brain aging are sexually dimorphic

artículo científico publicado en 2008

Gene expression of Alzheimer-associated presenilin-2 in the frontal cortex of Alzheimer and aged control brain

artículo científico publicado en 1996

Gliotoxic actions of excitatory amino acids

artículo científico publicado en 1992

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation

artículo científico publicado en 1988

H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus

artículo científico publicado en 2016

Healthy brain aging: a meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging

artículo científico publicado en 2008

Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate beta-amyloid(25-35) induced neurodegeneration in cultured hippocampal neurons.

artículo científico publicado en 1995

Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study

artículo científico publicado en 1997

Hippocampal but not astrocyte transplants enhance recovery on a forced choice alternation task after kainate lesions.

artículo científico publicado en 1988

Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline

scientific article published on 20 February 2019

IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking

scientific article published on 02 February 2017

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.

artículo científico publicado en 2018

Identification and distribution of axonal dystrophic neurites in Alzheimer's disease.

artículo científico publicado en 1993

Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I.

artículo científico publicado en 1987

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta

artículo científico publicado en 2006

Immunocytochemical localization of glutaminase-like and aspartate aminotransferase-like immunoreactivities in the rat and guinea pig hippocampus

artículo científico publicado en 1985

Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

artículo científico publicado en 1995

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.

artículo científico publicado en 2018

Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

artículo científico publicado en 1990

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

artículo científico publicado en 1994

Induction of a neurite-promoting factor in rat brain following injury or deafferentation

artículo científico publicado en 1986

Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites

scientific article published on 04 February 2019

Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid

artículo científico publicado en 1988

Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging

artículo científico publicado en 2000

Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction

scientific journal article

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

scientific article published on 04 November 2019

Isolated executive impairment and associated frontal neuropathology

scientific article published on January 2004

L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis

artículo científico publicado en 1985

L-glutamate receptor populations in synaptic membranes: effects of ions and pharmacological characteristics

artículo científico publicado en 1983

Lack of correlation between cortical levels of choline acetyltransferase and learning scores in rats with globus pallidus lesions

artículo científico publicado en 1986

Laminin supports short-term survival of rat septal neurons in low-density, serum-free cultures

artículo científico publicado en 1986

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study

artículo científico publicado en 2005

Learning deficits in rats with early neurotoxic lesions to the globus pallidus, substantia nigra, median raphe or pontine reticular formation

artículo científico publicado en 1986

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

artículo científico publicado en 2010

Localization and cell association of C1q in Alzheimer's disease brain

artículo científico publicado en 1996

Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

artículo científico publicado en 1992

Locomotor activity rhythms in dogs vary with age and cognitive status

artículo científico publicado en 2003

Long-term survival of neural transplants to senescence in rats

artículo científico publicado en 1990

Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs

artículo científico publicado en 2004

Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered

artículo científico publicado en 1998

Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging

artículo científico publicado en 1998

Mechanisms of neuronal death in Alzheimer's disease

artículo científico publicado en 1996

Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. I. Positional and temporal factors

artículo científico publicado en 1980

Microfluidic Multicompartment Device for Neuroscience Research

artículo científico publicado en 2003

Mild stress facilitates learning and exercise improves retention in aged mice ⬇️

artículo científico publicado el 15 de octubre de 2010

Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs

artículo científico publicado en 2000

N-methyl-D-aspartate receptors and Alzheimer's disease

artículo científico publicado en 1989

NGF receptor immunoreactivity in aged rat brain

artículo científico publicado en 1989

Neural stem cells rescue deficits in Alzheimer's transgenic mice

Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease

artículo científico publicado en 1993

Neurobiology of exercise

artículo científico publicado en 2006

Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function

artículo científico publicado en 2007

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

artículo científico publicado en 1999

Neuronotrophic activity for ciliary ganglion neurons. Induction following injury to the brain of neonatal, adult, and aged rats

artículo científico publicado en 1985

Neuronotrophic factors for mammalian brain neurons: injury induction in neonatal, adult and aged rat brain

artículo científico publicado en 1985

Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury

artículo científico publicado en 1989

Neutrophin-trafficking deficits are mediated by impaired ubiquitin recycling in Alzheimer's disease

scholarly article by Wayne W Poon et al published July 2012 in Alzheimer's and Dementia

Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic devices

artículo científico publicado en 2007

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

artículo científico publicado en 2012

Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

artículo científico publicado en 2016

Nutritional management of brain aging in dogs

artículo científico publicado en 2005

On the road towards the global analysis of human synapses.

artículo científico publicado en 2017

Open field activity and human interaction as a function of age and breed in dogs

artículo científico publicado en 1997

Overexpression of Bcl-2 in APP transgenic mice reduces amyloid pathology

scholarly article by Wayne W. Poon et al published July 2010 in Alzheimer's and Dementia

Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome

artículo científico publicado en 2001

Oxidative damage increases with age in a canine model of human brain aging

artículo científico publicado en 2002

P2‐179: MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS ⬇️

scholarly article

Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells

artículo científico publicado en 1999

Pattern separation and goal-directed behavior in the aged canine

artículo científico publicado en 2017

Patterned cell culture inside microfluidic devices.

artículo científico publicado en 2004

Perineuronal satellitosis in the human hippocampal formation

artículo científico publicado en 1993

Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses

artículo científico publicado en 2016

Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes

artículo científico publicado en 1994

Physical activity and the maintenance of cognition: learning from animal models

artículo científico publicado en 2007

Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments

artículo científico publicado en 1996

Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites

artículo científico publicado en 1998

Plasticity in Alzheimer's disease: too much or not enough?

artículo científico publicado en 1991

Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease

artículo científico publicado en 1986

Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease

scientific article published on January 1990

Plasticity of hippocampal circuitry in Alzheimer's disease

artículo científico publicado en 1985

Preferential adhesion of brain astrocytes to laminin and central neurites to astrocytes

artículo científico publicado en 1987

Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device

artículo científico publicado en 2007

Progress in facilitating the recovery of function after central nervous system trauma

artículo científico publicado en 1985

Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

artículo científico publicado en 1994

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

artículo científico publicado en 1989

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease ⬇️

artículo científico publicado en 2006

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models

artículo científico publicado en 2013

Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease

artículo científico publicado en 1991

Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons.

artículo científico publicado en 2012

Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy

artículo científico publicado en 2014

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment

artículo científico publicado en 2006

Region-specific age at onset of beta-amyloid in dogs

artículo científico publicado en 2000

Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells

artículo científico publicado en 2009

Response latency in Canis familiaris: Mental ability or mental strategy? ⬇️

artículo científico publicado el 1 de octubre de 2003

Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines

artículo científico publicado en 2008

Roles of metabotropic glutamate receptors in brain plasticity and pathology

artículo científico publicado en 1995

Senile plaques as aberrant sprout-stimulating structures

artículo científico publicado en 1986

Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment

artículo científico publicado en 1999

Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise

artículo científico publicado en 2016

Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles

artículo científico publicado en 2009

Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging

artículo científico publicado en 2003

Spatial learning and memory as a function of age in the dog.

artículo científico publicado en 1995

Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease

artículo científico publicado en 2003

Stimulation of phosphoinositide hydrolysis by trans-(+/-)-ACPD is greatly enhanced when astrocytes are cultured in a serum-free defined medium

artículo científico publicado en 1993

Stimulus secretion coupling in vitro: a rapid perfusion apparatus for monitoring efflux of transmitter substances from tissue samples ⬇️

artículo científico publicado en 1975

Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity

artículo científico publicado en 1995

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

artículo científico publicado en 2015

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease ⬇️

artículo científico publicado el 27 de diciembre de 2012

Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease

artículo científico publicado en 1988

Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines

artículo científico publicado en 2010

Synthesis of [3H]2-amino-4-phosphonobutyric acid and characterization of its binding to rat brain membranes: a selective ligand for the chloride/calcium-dependent class of L-glutamate binding sites

artículo científico publicado en 1983

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia

artículo científico publicado en 2010

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

artículo científico publicado en 2014

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse.

artículo científico publicado en 2018

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models

scientific article published on 27 February 2019

Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia

artículo científico publicado en 2003

The brain's microenvironment, early functional loss, and the conversion to Alzheimer's disease

artículo científico publicado en 2000

The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.

artículo científico publicado en 2008

The canine as an animal model of human aging and dementia

artículo científico publicado en 1996

The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system

artículo científico

The exercise-induced expression of BDNF within the hippocampus varies across life-span

artículo científico publicado en 2005

The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.

artículo científico publicado en 1999

The progression of beta-amyloid deposition in the frontal cortex of the aged canine

artículo científico publicado en 1997

The role of caspase cleavage of tau in Alzheimer disease neuropathology

artículo científico publicado en 2005

The role of trophic factors in behavioral recovery and integration of transplants

artículo científico publicado en 1988

The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise.

artículo científico publicado en 2004

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse

artículo científico publicado en 2007

Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro

artículo científico publicado en 1996

Topography, histology, and seminology in dementia

artículo científico publicado en 2000

Transplantation of septal neurons maintained in long-term culture

artículo científico publicado en 1986

Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation

artículo científico publicado en 1986

Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons

artículo científico publicado en 1994

Ultrastructural characterization of identified cholinergic neurons transplanted to the hippocampal formation of the rat.

artículo científico publicado en 1986

Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog.

artículo científico publicado en 2000

Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia

artículo científico publicado en 2006

Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility

artículo científico publicado en 2002

Voltage-gated currents expressed by rat microglia in culture

artículo científico publicado el 1 de enero de 1992

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.

artículo científico publicado en 2005

Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat.

artículo científico publicado en 1995

Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord.

artículo científico publicado en 2006

Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth.

artículo científico publicado en 2007

bFGF promotes the survival of entorhinal layer II neurons after perforant path axotomy

artículo científico publicado en 1992

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

artículo científico publicado en 1994

beta-Amyloid converts an acute phase injury response to chronic injury responses

artículo científico publicado en 1996

beta-Amyloid neurotoxicity: a discussion of in vitro findings

artículo científico publicado en 1992

miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease

scientific article published on 22 February 2020

β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

artículo científico publicado en 2013

β-Amyloid impairs axonal BDNF retrograde trafficking

artículo científico publicado en 2009

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