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Lista de obras de Tuomas Knowles

A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells ⬇️

artículo científico publicado en 2015

A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

artículo científico publicado en 2018

A microfluidic strategy for the detection of membrane protein interactions

artículo científico publicado en 2020

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

artículo científico publicado en 2017

Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.

artículo científico publicado en 2015

Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils

artículo científico publicado en 2020

Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials

artículo científico publicado en 2016

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis

artículo científico publicado en 2019

Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

scientific article published on 20 May 2020

Asymptotic solutions of the Oosawa model for the length distribution of biofilaments

artículo científico publicado en 2014

Attoliter protein nanogels from droplet nanofluidics for intracellular delivery

artículo científico publicado en 2020

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

artículo científico publicado en 2020

Autoantibodies against the prion protein in individuals with PRNP mutations

artículo científico publicado en 2020

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

scientific article published on 08 October 2019

Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation

artículo científico publicado en 2011

Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo

scientific article published on 17 February 2020

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

artículo científico publicado en 2020

Biosensor-based label-free assays of amyloid growth

artículo científico publicado en 2009

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

artículo científico publicado en 2018

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

artículo científico publicado en 2018

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

artículo científico publicado en 2018

Chemical and biophysical insights into the propagation of prion strains.

scientific article published on 13 October 2008

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

artículo científico publicado en 2018

Coating and Stabilization of Liposomes by Clathrin-Inspired DNA Self-Assembly

artículo científico publicado en 2020

Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing

article

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein ⬇️

artículo científico publicado el 12 de junio de 2011

Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation

scientific article published on 30 July 2018

Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation ⬇️

artículo científico publicado en 2016

Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films

artículo científico publicado en 2021

Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly.

artículo científico publicado en 2016

Cooperative Assembly of Hsp70 Subdomain Clusters

scientific article published on 29 May 2018

Crucial role of nonspecific interactions in amyloid nucleation. ⬇️

artículo científico publicado en 2014

DNA-Coated Functional Oil Droplets

artículo científico publicado en 2018

Density-Gradient-Free Microfluidic Centrifugation for Analytical and Preparative Separation of Nanoparticles

scientific article published on 07 April 2014

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

article

Determination of Polypeptide Conformation with Nanoscale Resolution in Water

artículo científico publicado en 2018

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

artículo científico publicado en 2014

Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit

artículo científico publicado en 2020

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

artículo científico publicado en 2020

Direct observation of murine prion protein replication in vitro

artículo científico publicado en 2018

Direct observation of oligomerization by single molecule fluorescence reveals a multi-step aggregation mechanism for the yeast prion protein Ure2.

artículo científico publicado en 2018

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

artículo científico publicado en 2019

Direct observation of the interconversion of normal and toxic forms of α-synuclein

artículo científico publicado en 2012

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

artículo científico publicado en 2018

Dynamic microfluidic control of supramolecular peptide self-assembly

artículo científico publicado en 2016

Dynamics of heteromolecular filament formation

artículo científico publicado en 2016

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

artículo científico publicado en 2020

Dynamics of protein aggregation and oligomer formation governed by secondary nucleation

artículo científico publicado en 2015

Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains

artículo científico publicado en 2014

Electrostatic effects in filamentous protein aggregation

artículo científico publicado en 2013

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

artículo científico publicado en 2016

Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems

artículo científico publicado en 2017

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

scientific article published on 19 July 2019

Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection

scientific article published on 09 July 2018

Environmental Control of Amyloid Polymorphism by Modulation of Hydrodynamic Stress

artículo científico publicado en 2020

Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.

artículo científico publicado en 2014

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

artículo científico publicado en 2018

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules

scientific article published on 06 March 2019

Fabrication and characterisation of protein fibril–elastomer composites

Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.

scientific article published on 11 October 2016

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers

artículo científico publicado en 2015

Fluctuations in the Kinetics of Linear Protein Self-Assembly.

artículo científico publicado en 2016

Force generation by the growth of amyloid aggregates.

artículo científico publicado en 2015

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

artículo científico publicado en 2010

Gradient-free determination of isoelectric points of proteins on chip.

artículo científico publicado en 2017

Half a century of amyloids: past, present and future

artículo científico publicado en 2020

Hamiltonian Dynamics of Protein Filament Formation

artículo científico publicado en 2016

Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry

artículo científico publicado en 2017

Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.

artículo científico publicado en 2008

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

article published in the Proceedings of the National Academy of Sciences of the United States of America

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

scientific article published on 30 August 2018

Identification of on- and off-pathway oligomers in amyloid fibril formation

scientific article published on 08 June 2020

Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics

scientific article published in Scientific Reports

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42

scientific article published on 08 March 2019

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

artículo científico publicado en 2013

Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors

artículo científico publicado en 2010

Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers. ⬇️

artículo científico publicado en 2017

Kinetic Analysis of Amyloid Formation

artículo científico publicado en 2018

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

artículo científico publicado en 2018

Kinetic constraints on self-assembly into closed supramolecular structures.

artículo científico publicado en 2017

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

artículo científico publicado en 2020

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

artículo científico publicado en 2016

Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments. ⬇️

artículo científico publicado en 2016

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation. ⬇️

artículo científico publicado en 2016

Label-Free Analysis of Protein Aggregation and Phase Behavior

artículo científico publicado en 2019

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

artículo científico publicado en 2015

Lipid-Stabilized Double Emulsions Generated in Planar Microfluidic Devices

artículo científico publicado en 2020

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

artículo científico publicado en 2018

Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements.

artículo científico publicado en 2017

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

article

Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2

artículo científico publicado en 2022

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

artículo científico publicado en 2016

Microfluidic Templating of Spatially Inhomogeneous Protein Microgels

artículo científico publicado en 2020

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

artículo científico publicado en 2018

Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning

artículo científico publicado en 2017

Microfluidics for protein biophysics

artículo científico publicado en 2017

Modulating the Mechanical Performance of Macroscale Fibers through Shear-Induced Alignment and Assembly of Protein Nanofibrils

artículo científico publicado en 2019

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

artículo científico publicado en 2017

Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation

artículo científico publicado en 2015

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

artículo científico publicado en 2016

Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions

artículo científico publicado en 2020

Multidimensional protein characterisation using microfluidic post-column analysis

artículo científico publicado en 2020

Multiphase protein microgels.

artículo científico publicado en 2014

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

artículo científico publicado en 2016

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

artículo científico publicado en 2015

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

artículo científico publicado en 2017

Nanomechanics of functional and pathological amyloid materials.

artículo científico

Nanoscale click-reactive scaffolds from peptide self-assembly.

artículo científico publicado en 2017

Nanoscale spatially resolved infrared spectra from single microdroplets ⬇️

artículo científico publicado en 2014

Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity

artículo científico publicado en 2015

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

scientific article published on 17 July 2018

Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function. ⬇️

artículo científico publicado en 2016

On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide

scientific article published on 10 November 2020

On the role of sidechain size and charge in the aggregation of A42 with familial mutations

article published in the Proceedings of the National Academy of Sciences of the United States of America

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.

artículo científico publicado en 2017

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

artículo científico publicado en 2018

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

scientific article published on 13 June 2018

Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

artículo científico publicado en 2014

Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.

artículo científico publicado en 2013

Physical principles of filamentous protein self-assembly kinetics.

artículo científico publicado en 2017

Population of nonnative states of lysozyme variants drives amyloid fibril formation

artículo científico publicado en 2011

Position-dependent electrostatic protection against protein aggregation

artículo científico publicado en 2009

Preventing peptide and protein misbehavior.

artículo científico publicado en 2015

Probing Protein Aggregation with Quartz Crystal Microbalances ⬇️

artículo científico publicado el 1 de enero de 2011

Probing small molecule binding to amyloid fibrils

artículo científico publicado en 2011

Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation

artículo científico publicado en 2016

Protein Aggregation in Crowded Environments

artículo científico publicado en 2010

Protein micro- and nano-capsules for biomedical applications

artículo científico

Protein microgels from amyloid fibril networks

artículo científico publicado en 2015

Pulsed Hydrogen-Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer's Disease Mutants

artículo científico publicado en 2021

Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay.

artículo científico publicado en 2013

Quantifying Co-Oligomer Formation by α-Synuclein

artículo científico publicado en 2018

Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.

artículo científico publicado en 2014

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms

artículo científico publicado en 2016

Quantitative thermophoretic study of disease-related protein aggregates

artículo científico publicado en 2016

Rapid Growth of Acetylated Aβ(16–20) into Macroscopic Crystals

artículo científico publicado en 2018

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

artículo científico publicado en 2020

Real-time intrinsic fluorescence visualisation and sizing of proteins and protein complexes in microfluidic devices.

artículo científico publicado en 2018

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

artículo científico publicado en 2021

Relationship between prion propensity and the rates of individual molecular steps of fibril assembly

artículo científico publicado en 2011

Role of elongation and secondary pathways in S6 amyloid fibril growth.

artículo científico publicado en 2012

Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization.

artículo científico publicado en 2014

Role of intermolecular forces in defining material properties of protein nanofibrils

artículo científico publicado en 2007

SAR by kinetics for drug discovery in protein misfolding diseases

article published in the Proceedings of the National Academy of Sciences of the United States of America

Scaling behaviour and rate-determining steps in filamentous self-assembly

artículo científico publicado en 2017

Secondary nucleation in amyloid formation

artículo científico publicado en 2018

Self-Assembly of Amyloid Fibrils That Display Active Enzymes.

artículo científico publicado en 2014

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces

scientific article published on 09 August 2018

Silk micrococoons for protein stabilisation and molecular encapsulation

artículo científico publicado en 2017

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

artículo científico publicado en 2020

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants

artículo científico publicado en 2015

Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.

artículo científico publicado en 2013

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

artículo científico publicado en 2020

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

artículo científico publicado en 2019

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

artículo científico publicado en 2014

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

scholarly article by Zhaoying Li published in September 2018

Spatial Propagation of Protein Polymerization

scientific article published in Physical Review Letters

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

artículo científico publicado en 2022

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

artículo científico publicado en 2018

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

artículo científico publicado en 2010

Statistical Mechanics of Globular Oligomer Formation by Protein Molecules

artículo científico publicado en 2018

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

artículo científico publicado en 2015

Surface attachment of protein fibrils via covalent modification strategies

artículo científico publicado en 2010

Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform

artículo científico publicado en 2016

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

artículo científico publicado en 2017

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

artículo científico publicado en 2014

Tetracycline nanoparticles as antibacterial and gene-silencing agents

artículo científico publicado en 2014

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.

artículo científico publicado en 2015

The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner

scientific article published on 17 May 2006

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

scientific article published on 17 March 2020

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

artículo científico publicado en 2016

The catalytic nature of protein aggregation

artículo científico publicado en 2020

The length distribution of frangible biofilaments.

artículo científico publicado en 2015

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

artículo científico publicado en 2014

The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.

artículo científico publicado en 2014

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit

artículo científico publicado en 2017

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

artículo científico publicado en 2020

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates.

artículo científico publicado en 2017

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion

artículo científico publicado en 2018

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

artículo científico publicado en 2016

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