Lista de obras - David J Wyllie - Dominio Público Uruguay

2B or 2B and 2D? - that is the question

artículo científico publicado en 2008

3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) Stereoisomers as Conformational Probes for Exploring Agonist Binding at NMDA Receptors

scientific article published on 12 June 2012

A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum.

artículo científico publicado en 1994

A rise in postsynaptic Ca2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons.

artículo científico publicado en 1994

Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures.

artículo científico publicado en 1991

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity

artículo científico publicado en 2009

Altered dendritic spine function and integration in a mouse model of fragile X syndrome

artículo científico publicado en 2019

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

artículo científico publicado en 2018

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

artículo científico publicado en 2018

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

artículo científico publicado en 2017

Cellular and Synaptic Phenotype Compensations Limit Circuit Disruption in Fmr1-KO Mouse Layer 4 Barrel Cortex but Fail to Prevent Deficits in Information Processing

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

scientific article published on 23 October 2019

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

artículo científico publicado en 2013

Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

artículo científico publicado en 2015

Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice

artículo científico publicado en 2015

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

scientific article published on 19 June 2020

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

artículo científico publicado en 1995

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

artículo científico publicado en 2012

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

artículo científico publicado en 2010

Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons

artículo científico publicado en 2015

Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies

artículo científico publicado en 2006

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

scientific article published on October 2016

Fragile X syndrome: from targets to treatments

artículo científico publicado en 2012

Functional assessment of the NMDA receptor variant GluN2A R586K.

artículo científico publicado en 2017

Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy

artículo científico publicado en 2019

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

artículo científico publicado en 2015

GRIN2A-related disorders: genotype and functional consequence predict phenotype

artículo científico publicado en 2019

Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells.

artículo científico publicado en 2014

Glutamate receptor gating.

artículo científico publicado en 2004

Glutamate-receptor channels in mammalian glial cells.

artículo científico publicado en 1991

Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization

artículo científico publicado en 2009

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration

artículo científico publicado en 2010

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

artículo científico publicado en 2015

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

artículo científico publicado en 1998

Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones

artículo científico publicado en 2005

Influence of GluN2 subunit identity on NMDA receptor function.

artículo científico

Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors

scientific journal article

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.

artículo científico publicado en 2009

Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit.

artículo científico publicado en 2009

Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

artículo científico publicado en 2009

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

artículo científico publicado en 2012

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

artículo científico publicado en 2014

Late-phase, protein synthesis-dependent long-term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks.

artículo científico publicado en 2007

Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.

artículo científico publicado en 2010

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells

scientific article published on 01 August 2018

Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses

artículo científico publicado en 2017

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

artículo científico publicado en 2016

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons

artículo científico publicado en 2014

Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog.

artículo científico publicado en 2005

Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

artículo científico publicado en 2007

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

artículo científico publicado en 2013

Modelling the details: integrating structure with function

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

artículo científico publicado en 2007

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

artículo científico publicado en 2012

NMDA receptor permeation: a light in the tunnel

artículo científico publicado en 2012

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

artículo científico publicado en 2015

Neuronal homeostasis: time for a change? ⬇️

artículo científico publicado el 8 de agosto de 2011

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

artículo científico publicado en 2017

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

scientific journal article

Parvalbumin interneurons in the dorsal horn: it's not all about GABA.

artículo científico publicado en 2017

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

scientific journal article

Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors

artículo científico publicado en 2006

Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels.

artículo científico publicado en 2006

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells

scientific article published on 17 January 2014

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.

artículo científico publicado en 2016

Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons

artículo científico publicado en 2018

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

artículo científico publicado en 2017

Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs ⬇️

artículo científico publicado el 16 de octubre de 2010

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure

artículo científico publicado en 2013

Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy

artículo científico publicado en 2017

Single cell RT-PCR reaches out to the NMDA receptor

artículo científico publicado en 1997

Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit

artículo científico publicado en 2006

Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits

artículo científico publicado en 2009

Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells

artículo científico publicado en 2000

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand

artículo científico publicado en 2008

Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

artículo científico publicado en 2005

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

artículo científico publicado en 2007

Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.

artículo científico publicado en 2005

Suppression of the intrinsic apoptosis pathway by synaptic activity.

artículo científico publicado en 2010

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

artículo científico publicado en 2019

SynGAP isoforms exert opposing effects on synaptic strength

artículo científico publicado en 2012

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

artículo científico publicado en 2008

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

artículo científico publicado en 2017

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

article

The human NMDA receptor GluN2AN615K variant influences channel blocker potency.

artículo científico publicado en 2019

The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells

artículo científico publicado en 2006

The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults

artículo científico publicado en 2012

The ups and downs of synaptic plasticity: influences on this particular 'market'.

artículo científico publicado en 2008

VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S).

artículo científico publicado en 2008

Lista de obras de David J Wyllie

2B or 2B and 2D? - that is the question

3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) Stereoisomers as Conformational Probes for Exploring Agonist Binding at NMDA Receptors

A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum.

A rise in postsynaptic Ca2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons.

Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures.

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity

Altered dendritic spine function and integration in a mouse model of fragile X syndrome

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Cellular and Synaptic Phenotype Compensations Limit Circuit Disruption in Fmr1-KO Mouse Layer 4 Barrel Cortex but Fail to Prevent Deficits in Information Processing

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons

Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

Fragile X syndrome: from targets to treatments

Functional assessment of the NMDA receptor variant GluN2A R586K.

Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

GRIN2A-related disorders: genotype and functional consequence predict phenotype

Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells.

Glutamate receptor gating.

Glutamate-receptor channels in mammalian glial cells.

Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones

Influence of GluN2 subunit identity on NMDA receptor function.

Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.

Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit.

Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

Late-phase, protein synthesis-dependent long-term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks.

Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells

Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons

Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog.

Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

Modelling the details: integrating structure with function

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

NMDA receptor permeation: a light in the tunnel

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

Neuronal homeostasis: time for a change? ⬇️

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

Parvalbumin interneurons in the dorsal horn: it's not all about GABA.

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors

Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels.

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.

Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs ⬇️

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure

Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy

Single cell RT-PCR reaches out to the NMDA receptor

Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit

Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits

Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand

Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.

Suppression of the intrinsic apoptosis pathway by synaptic activity.