Lista de obras - Emmanuel Lemichez - Dominio Público Uruguay

ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

artículo científico publicado en 2017

ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion

artículo científico publicado en 2005

Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process

artículo científico publicado en 2007

Activation and proteasomal degradation of rho GTPases by cytotoxic necrotizing factor-1 elicit a controlled inflammatory response

artículo científico publicado en 2004

Assessing ubiquitylation of Rho GTPases in mammalian cells.

artículo científico publicado en 2012

Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.

artículo científico publicado en 2012

Bacillus sphaericus binary toxin elicits host cell autophagy as a response to intoxication

artículo científico publicado en 2011

Bacteria and the ubiquitin pathway

artículo científico publicado en 2006

Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?

artículo científico publicado en 2003

Breaking the wall: targeting of the endothelium by pathogenic bacteria

artículo científico publicado en 2009

CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion

artículo científico publicado en 2002

CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells

artículo científico publicado en 2006

CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.

artículo científico publicado en 2018

Cellular Dewetting: Opening of Macroapertures in Endothelial Cells

artículo científico publicado en 2012

Cellular microbiology: Bacterial toxin interference drives understanding of eukaryotic cell function

scientific article published on 01 April 2020

Characterization of a cluster of oncogenic mutations in E6 of a human papillomavirus 83 variant isolated from a high-grade squamous intraepithelial lesion

artículo científico publicado en 2011

Cholera toxin notches epithelial junctions.

artículo científico publicado en 2013

Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery

artículo científico publicado en 2015

Coxiella burnetii, the agent of Q fever, replicates within trophoblasts and induces a unique transcriptional response

artículo científico publicado en 2010

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells

artículo científico publicado en 2011

Cross-talk between RhoGTPases and stress activated kinases for matrix metalloproteinase-9 induction in response to keratinocytes injury.

artículo científico publicado en 2003

Decoding glycan recognition by bacterial toxins

artículo científico publicado en 2018

Direct modifications of Rho proteins: deconstructing GTPase regulation

artículo científico publicado en 2010

E. coli CNF1 toxin: a two-in-one system for host-cell invasion.

artículo científico publicado en 2004

EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia

artículo científico publicado en 2015

Escherichia coli producing CNF1 toxin hijacks Tollip to trigger Rac1-dependent cell invasion

artículo científico publicado en 2011

Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia

artículo científico publicado en 2015

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

artículo científico publicado en 2018

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

Force-induced transcellular tunnel formation in endothelial cells

artículo científico publicado en 2017

General aspects and recent advances on bacterial protein toxins

artículo científico publicado en 2013

Genetic Diversity and Population Structure of Leishmania infantum from Southeastern France: Evaluation Using Multi-Locus Microsatellite Typing

artículo científico publicado en 2016

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

artículo científico publicado en 2018

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

artículo científico publicado en 2013

Hijacking of Rho GTPases during bacterial infection

artículo científico

IRSp53 senses negative membrane curvature and phase separates along membrane tubules

artículo científico publicado en 2015

Immunoadjuvant Properties of the Rho Activating Factor CNF1 in Prophylactic and Curative Vaccination against Leishmania infantum

artículo científico publicado en 2016

Impaired Stimulation of p38α-MAPK/Vps41-HOPS by LPS from Pathogenic Coxiella burnetii Prevents Trafficking to Microbicidal Phagolysosomes

scholarly article published by Philippe Soubeyran in 2012

In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification

artículo científico publicado en 2022

Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors

artículo científico publicado en 2006

Inhibition of p21 Rho in intact cells by C3 diphtheria toxin chimera proteins.

artículo científico publicado en 1995

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

artículo científico publicado en 2014

Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability

artículo científico publicado en 2009

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

artículo científico publicado en 2001

Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection

artículo científico publicado en 2010

Intranasal immunization with tetanus toxoid and CNF1 as a new mucosal adjuvant protects BALB/c mice against lethal challenge

artículo científico publicado en 2007

Isoform-specific interaction of C-RAF with mitochondria

artículo científico publicado en 2008

Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells

artículo científico publicado en 2011

Luciferase-expressing Leishmania infantum allows the monitoring of amastigote population size, in vivo, ex vivo and in vitro

artículo científico publicado en 2011

Microbial pathogenesis meets biomechanics

artículo científico publicado en 2016

Modification of Salmonella Typhimurium motility by the probiotic yeast strain Saccharomyces boulardii

artículo científico publicado en 2012

New Aspects on Bacterial Effectors Targeting Rho GTPases

artículo científico publicado en 2016

Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis

artículo científico publicado en 2008

Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells

artículo científico publicado en 2005

Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes

artículo científico publicado en 2003

Rac homologues and compartmentalized phosphatidylinositol 4, 5-bisphosphate act in a common pathway to regulate polar pollen tube growth.

artículo científico publicado en 1999

Rac1 est la cible de l’activité E3 ubiquitine-ligase du suppresseur de tumeur HACE1

artículo científico publicado en 2012

Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

artículo científico publicado en 1996

Response from Emmanuel Lemichez: A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors.

artículo científico publicado en 2003

Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology

artículo científico publicado en 2007

Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA)

artículo científico publicado en 2012

Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract

artículo científico publicado en 2014

Screening in planarians identifies MORN2 as a key component in LC3-associated phagocytosis and resistance to bacterial infection

artículo científico publicado en 2014

Screening of drug library identifies inhibitors of cell intoxication by CNF1.

artículo científico publicado en 2018

Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model.

artículo científico publicado en 2012

Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli

artículo científico publicado en 2007

Switching Rho GTPase activation into effective antibacterial defenses requires the caspase-1/IL-1beta signaling axis

artículo científico publicado en 2015

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

artículo científico publicado en 2016

Targeting of host-cell ubiquitin and ubiquitin-like pathways by bacterial factors

artículo científico publicado en 2004

The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization

artículo científico publicado en 2022

The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1

artículo científico publicado en 2011

The Rho GTPase activators CNF1 and DNT bacterial toxins have mucosal adjuvant properties

artículo científico publicado en 2005

The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt

artículo científico publicado en 2010

The Saccharomyces boulardii CNCM I-745 strain shows protective effects against the B. anthracis LT toxin

artículo científico publicado en 2015

The Staphylococcus aureus epidermal cell differentiation inhibitor toxin promotes formation of infection foci in a mouse model of bacteremia

artículo científico publicado en 2010

The evolution of contact-dependent inhibition in non-growing populations of Escherichia coli

artículo científico publicado en 2008

To be helped or not helped, that is the question

artículo científico publicado en 2003

Toxins activating Rho GTPases and exploiting the cellular ubiquitin/proteasome machineries

Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I-BAR proteins

artículo científico

Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity

artículo científico publicado en 2010

Ubiquitin-mediated proteasomal degradation of Rho proteins by the CNF1 toxin

artículo científico publicado en 2006

Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs

artículo científico publicado en 2005

alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells

artículo científico publicado en 2010

cAMP Signaling by Anthrax Edema Toxin Induces Transendothelial Cell Tunnels, which Are Resealed by MIM via Arp2/3-Driven Actin Polymerization

artículo científico publicado en 2011

Lista de obras de Emmanuel Lemichez

ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion

Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process

Activation and proteasomal degradation of rho GTPases by cytotoxic necrotizing factor-1 elicit a controlled inflammatory response

Assessing ubiquitylation of Rho GTPases in mammalian cells.

Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.

Bacillus sphaericus binary toxin elicits host cell autophagy as a response to intoxication

Bacteria and the ubiquitin pathway

Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?

Breaking the wall: targeting of the endothelium by pathogenic bacteria

CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion

CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells

CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.

Cellular Dewetting: Opening of Macroapertures in Endothelial Cells

Cellular microbiology: Bacterial toxin interference drives understanding of eukaryotic cell function

Characterization of a cluster of oncogenic mutations in E6 of a human papillomavirus 83 variant isolated from a high-grade squamous intraepithelial lesion

Cholera toxin notches epithelial junctions.

Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery

Coxiella burnetii, the agent of Q fever, replicates within trophoblasts and induces a unique transcriptional response

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells

Cross-talk between RhoGTPases and stress activated kinases for matrix metalloproteinase-9 induction in response to keratinocytes injury.

Decoding glycan recognition by bacterial toxins

Direct modifications of Rho proteins: deconstructing GTPase regulation

E. coli CNF1 toxin: a two-in-one system for host-cell invasion.

EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia

Escherichia coli producing CNF1 toxin hijacks Tollip to trigger Rac1-dependent cell invasion

Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

Force-induced transcellular tunnel formation in endothelial cells

General aspects and recent advances on bacterial protein toxins

Genetic Diversity and Population Structure of Leishmania infantum from Southeastern France: Evaluation Using Multi-Locus Microsatellite Typing

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

Hijacking of Rho GTPases during bacterial infection

IRSp53 senses negative membrane curvature and phase separates along membrane tubules

Immunoadjuvant Properties of the Rho Activating Factor CNF1 in Prophylactic and Curative Vaccination against Leishmania infantum

Impaired Stimulation of p38α-MAPK/Vps41-HOPS by LPS from Pathogenic Coxiella burnetii Prevents Trafficking to Microbicidal Phagolysosomes

In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification

Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors

Inhibition of p21 Rho in intact cells by C3 diphtheria toxin chimera proteins.

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection

Intranasal immunization with tetanus toxoid and CNF1 as a new mucosal adjuvant protects BALB/c mice against lethal challenge

Isoform-specific interaction of C-RAF with mitochondria

Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells

Luciferase-expressing Leishmania infantum allows the monitoring of amastigote population size, in vivo, ex vivo and in vitro

Microbial pathogenesis meets biomechanics

Modification of Salmonella Typhimurium motility by the probiotic yeast strain Saccharomyces boulardii

New Aspects on Bacterial Effectors Targeting Rho GTPases

Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis

Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells

Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes

Rac homologues and compartmentalized phosphatidylinositol 4, 5-bisphosphate act in a common pathway to regulate polar pollen tube growth.

Rac1 est la cible de l’activité E3 ubiquitine-ligase du suppresseur de tumeur HACE1

Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

Response from Emmanuel Lemichez: A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors.

Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology

Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA)

Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract

Screening in planarians identifies MORN2 as a key component in LC3-associated phagocytosis and resistance to bacterial infection

Screening of drug library identifies inhibitors of cell intoxication by CNF1.

Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model.

Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli

Switching Rho GTPase activation into effective antibacterial defenses requires the caspase-1/IL-1beta signaling axis

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Targeting of host-cell ubiquitin and ubiquitin-like pathways by bacterial factors

The <i>cnf1</i> gene is associated with an expanding <i>Escherichia coli</i> ST131 <i>H</i>30Rx/C2 subclade and confers a competitive advantage for gut colonization

The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1

The Rho GTPase activators CNF1 and DNT bacterial toxins have mucosal adjuvant properties

The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt

The Saccharomyces boulardii CNCM I-745 strain shows protective effects against the B. anthracis LT toxin

The Staphylococcus aureus epidermal cell differentiation inhibitor toxin promotes formation of infection foci in a mouse model of bacteremia

The evolution of contact-dependent inhibition in non-growing populations of Escherichia coli

To be helped or not helped, that is the question

Toxins activating Rho GTPases and exploiting the cellular ubiquitin/proteasome machineries

Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I-BAR proteins