Lista de obras - Steven W Polyak - Dominio Público Uruguay

A hypoxia-activated antibacterial prodrug

scientific article published on 27 March 2020

A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.

artículo científico publicado en 2004

A novel molecular mechanism to explain biotin-unresponsive holocarboxylase synthetase deficiency

artículo científico publicado en 2011

A novel tool for studying auxin-metabolism: the inhibition of grapevine indole-3-acetic acid-amido synthetases by a reaction intermediate analogue

artículo científico publicado en 2012

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

scientific article published on 06 April 2020

Biosynthetically Guided Structure-Activity Relationship Studies of Merochlorin A, an Antibiotic Marine Natural Product.

artículo científico publicado en 2017

Biotin Protein Ligase Is a Target for New Antibacterials

artículo científico publicado en 2016

Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

artículo científico publicado en 2012

Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention.

artículo científico

Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin.

artículo científico publicado en 2018

Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers

scientific article published on 27 June 2007

Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance

scientific article published on 27 November 2020

Design and synthesis of novel 4-substituted quinazoline-2-carboxamide derivatives targeting AcrB to reverse the bacterial multidrug resistance

artículo científico publicado en 2020

Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance

artículo científico publicado en 2019

Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus

artículo científico publicado en 2013

Escherichia coli biotin protein ligase: characterization and development of a high-throughput assay

artículo científico publicado en 2008

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.

artículo científico publicado en 2017

Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase

scientific article published on 19 August 2014

Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6

scientific article published on 14 November 2019

Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery

artículo científico publicado en 2014

Localization of inhibitory antibodies to the biotin domain of human pyruvate carboxylase.

artículo científico publicado en 2012

Measuring Small Molecule Binding to Escherichia coli AcrB by Surface Plasmon Resonance

artículo científico publicado en 2020

Mechanisms Governing Precise Protein Biotinylation.

artículo científico publicado en 2017

Mechanisms of biotin-regulated gene expression in microbes

artículo científico publicado en 2016

Molecular cloning and characterization of a new cold-active esterase from a deep-sea metagenomic library.

artículo científico publicado en 2011

Mutational analysis of protein substrate presentation in the post-translational attachment of biotin to biotin domains.

artículo científico publicado en 2000

Native mass spectrometry identifies an alternative DNA-binding pathway for BirA from Staphylococcus aureus

scientific article published on 26 February 2019

New Isocoumarin Analogues from the Marine-Derived Fungus Paraphoma sp. CUGBMF180003 ⬇️

scientific article published in 2021

New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase.

artículo científico publicado en 2016

Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase

artículo científico publicado en 2015

Photopharmacological Control of Cyclic Antimicrobial Peptides

artículo científico publicado en 2018

Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase

artículo científico publicado en 2018

Purification, crystallization and preliminary crystallographic analysis of biotin protein ligase from Staphylococcus aureus.

artículo científico publicado en 2008

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

artículo científico publicado en 2015

Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus

artículo científico publicado en 2012

Self-association of the Shigella flexneri IcsA autotransporter protein.

artículo científico publicado en 2012

Structural characterisation of Staphylococcus aureus biotin protein ligase and interaction partners: An antibiotic target

artículo científico publicado en 2013

Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target

artículo científico publicado en 2013

Structural optimization of natural product nordihydroguaretic acid to discover novel analogues as AcrB inhibitors

scientific article published on 26 November 2019

Structure guided design of biotin protein ligase inhibitors for antibiotic discovery

artículo científico

Structure, function and selective inhibition of bacterial acetyl-coa carboxylase ⬇️

artículo científico publicado el 20 de diciembre de 2011

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

artículo científico publicado en 2019

Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa.

artículo científico publicado en 2011

The Role of Biotin in Bacterial Physiology and Virulence: a Novel Antibiotic Target for Mycobacterium tuberculosis

artículo científico publicado en 2016

Two New Piperazine-Triones from a Marine-Derived sp. Strain SMS636 ⬇️

scientific article published on 21 March 2019

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049 ⬇️

scientific article published on 14 May 2019

Lista de obras de Steven W Polyak

A hypoxia-activated antibacterial prodrug

A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.

A novel molecular mechanism to explain biotin-unresponsive holocarboxylase synthetase deficiency

A novel tool for studying auxin-metabolism: the inhibition of grapevine indole-3-acetic acid-amido synthetases by a reaction intermediate analogue

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

Biosynthetically Guided Structure-Activity Relationship Studies of Merochlorin A, an Antibiotic Marine Natural Product.

Biotin Protein Ligase Is a Target for New Antibacterials

Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention.

Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin.

Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers

Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance

Design and synthesis of novel 4-substituted quinazoline-2-carboxamide derivatives targeting AcrB to reverse the bacterial multidrug resistance

Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance

Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus

Escherichia coli biotin protein ligase: characterization and development of a high-throughput assay

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.

Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase

Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6

Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery

Localization of inhibitory antibodies to the biotin domain of human pyruvate carboxylase.

Measuring Small Molecule Binding to Escherichia coli AcrB by Surface Plasmon Resonance

Mechanisms Governing Precise Protein Biotinylation.

Mechanisms of biotin-regulated gene expression in microbes

Molecular cloning and characterization of a new cold-active esterase from a deep-sea metagenomic library.

Mutational analysis of protein substrate presentation in the post-translational attachment of biotin to biotin domains.

Native mass spectrometry identifies an alternative DNA-binding pathway for BirA from Staphylococcus aureus

New Isocoumarin Analogues from the Marine-Derived Fungus Paraphoma sp. CUGBMF180003 ⬇️

New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase.

Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase

Photopharmacological Control of Cyclic Antimicrobial Peptides

Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase

Purification, crystallization and preliminary crystallographic analysis of biotin protein ligase from Staphylococcus aureus.

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus

Self-association of the Shigella flexneri IcsA autotransporter protein.

Structural characterisation of Staphylococcus aureus biotin protein ligase and interaction partners: An antibiotic target

Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target

Structural optimization of natural product nordihydroguaretic acid to discover novel analogues as AcrB inhibitors

Structure guided design of biotin protein ligase inhibitors for antibiotic discovery

Structure, function and selective inhibition of bacterial acetyl-coa carboxylase ⬇️

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa.

The Role of Biotin in Bacterial Physiology and Virulence: a Novel Antibiotic Target for Mycobacterium tuberculosis

Two New Piperazine-Triones from a Marine-Derived sp. Strain SMS636 ⬇️

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049 ⬇️