Lista de obras - David O'Hagan - Dominio Público Uruguay

A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic [18 F]Fluorination for PET Imaging.

artículo científico publicado en 2017

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions.

artículo científico publicado en 2014

A two-step fluorinase enzyme mediated (18)F labelling of an RGD peptide for positron emission tomography.

artículo científico publicado en 2015

Acetyl Coenzyme A Analogues as Rationally Designed Inhibitors of Citrate Synthase

artículo científico publicado en 2019

Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABAC receptors ⬇️

artículo científico publicado el 13 de junio de 2011

All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane

artículo científico publicado en 2015

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

artículo científico publicado en 2019

Analysis of CF···FC Interactions on Cyclohexane and Naphthalene Frameworks

article

Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs: a gas-phase C-C bond-forming reaction on a surface.

artículo científico publicado en 2014

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells.

artículo científico publicado en 2016

Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor.

artículo científico publicado en 2013

Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging

artículo científico publicado en 2018

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

scientific article published on 01 February 2019

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

artículo científico publicado en 2016

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme

artículo científico publicado en 2016

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

scientific article published on 03 May 2015

Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate ⬇️

artículo científico publicado el 20 de septiembre de 2010

Fluorinated Musk Fragrances: The CF2 Group as a Conformational Bias Influencing the Odour of Civetone and (R)-Muscone.

artículo científico publicado en 2016

Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif. ⬇️

artículo científico publicado en 2017

Fluorinated cyclopropanes: synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif

artículo científico publicado en 2018

Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications.

artículo científico publicado en 2016

Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif

artículo científico publicado en 2015

Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

scientific article published on 01 August 2019

Fluorine in fragrances: exploring the difluoromethylene (CF2) group as a conformational constraint in macrocyclic musk lactones

artículo científico publicado en 2016

Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif

artículo científico publicado en 2019

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674.

artículo científico publicado en 2014

Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

artículo científico publicado en 2016

Hyperconjugation Is the Source of Helicity in Perfluorinated n-Alkanes

artículo científico publicado en 2017

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid†

artículo científico publicado en 2014

Identification of fluorinases from streptomyces sp MA37, norcardia brasiliensis, and actinoplanes sp N902-109 by genome mining

artículo científico publicado en 2014

Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus ⬇️

artículo científico publicado en 2017

Inter- and intramolecular CF···co interactions on aliphatic and cyclohexane carbonyl derivatives

scientific article published on 23 April 2015

Interaction of B12F122- with All-cis 1,2,3,4,5,6 Hexafluorocyclohexane in the Gas Phase

artículo científico publicado en 2016

Janus Face Aspect of All-cis 1,2,3,4,5,6-Hexafluorocyclohexane Dictates Remarkable Anion and Cation Interactions In the Gas Phase.

artículo científico publicado en 2016

Last-Step Enzymatic [(18) F]-Fluorination of Cysteine-Tethered RGD Peptides Using Modified Barbas Linkers

artículo científico publicado en 2016

Lewis acid-promoted hydrofluorination of alkynyl sulfides to generate α-fluorovinyl thioethers.

artículo científico publicado en 2015

Metabolism and hydrophilicity of the polarised 'Janus face' all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery.

artículo científico publicado en 2018

Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.

artículo científico publicado en 2018

Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes.

artículo científico publicado en 2015

Organic chemistry on surfaces: Direct cyclopropanation by dihalocarbene addition to vinyl terminated self-assembled monolayers (SAMs)

artículo científico publicado en 2014

Organo-fluorine chemistry III.

artículo científico publicado en 2013

Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring.

artículo científico publicado en 2016

Particularly strong C–H⋯π interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane

article

Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane

artículo científico publicado en 2016

Probing the helical integrity of multivicinal all-syn-fluoro alkanes

scientific article published on 16 January 2020

Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane

artículo científico publicado en 2015

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells.

artículo científico publicado en 2017

Stepwise preparation of all-cis 1,3,4-trifluoro-2-phenylcyclohexane, avoiding a phenonium intermediate

artículo científico publicado en 2014

Stereochemical outcomes of C-F activation reactions of benzyl fluoride.

artículo científico publicado en 2018

Stereoselective alpha-fluoroamide and alpha-fluoro-gamma-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement.

artículo científico publicado en 2005

Supramolecular packing of alkyl substituted Janus face all-cis 2,3,4,5,6-pentafluorocyclohexyl motifs

artículo científico publicado en 2021

Synthesis and elaboration of all-cis-1,2,4,5-tetrafluoro-3-phenylcyclohexane: a polar cyclohexane motif

artículo científico publicado en 2014

Synthesis and structure of large difluoromethylene containing alicycles by ring closing metathesis (RCM).

artículo científico publicado en 2013

Synthesis of aryl α,α-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl α,α-difluoro oxyethers

artículo científico publicado en 2018

Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes

artículo científico publicado en 2020

The Synthesis and Evaluation of Fluoro-, Trifluoromethyl-, and Iodomuscimols as GABA Agonists.

artículo científico publicado en 2017

The difluoromethylene (CF2) group in aliphatic chains: Synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups

artículo científico publicado en 2014

The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes.

artículo científico publicado en 2012

The rare fluorinated natural products and biotechnological prospects for fluorine enzymology

artículo científico publicado en 2012

Total Synthesis of a Reported Fluorometabolite from Streptomyces sp. TC1 Indicates an Incorrect Assignment. The Isolated Compound Did Not Contain Fluorine

artículo científico publicado en 2014

Two 3'-O-β-glucosylated nucleoside fluorometabolites related to nucleocidin in Streptomyces calvus ⬇️

artículo científico publicado en 2019

Unexpected α,α'-difluoroethers from Ag(i)F and N-bromosuccinimide reactions of dibenzo[a,e]cyclooctatetraene

scientific article published on 01 November 2019

Lista de obras de David O'Hagan

A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic [18 F]Fluorination for PET Imaging.

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions.

A two-step fluorinase enzyme mediated (18)F labelling of an RGD peptide for positron emission tomography.

Acetyl Coenzyme A Analogues as Rationally Designed Inhibitors of Citrate Synthase

Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABAC receptors ⬇️

All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

Analysis of CF···FC Interactions on Cyclohexane and Naphthalene Frameworks

Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs: a gas-phase C-C bond-forming reaction on a surface.

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells.

Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor.

Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate ⬇️

Fluorinated Musk Fragrances: The CF2 Group as a Conformational Bias Influencing the Odour of Civetone and (R)-Muscone.

Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif. ⬇️

Fluorinated cyclopropanes: synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif

Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications.

Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif

Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

Fluorine in fragrances: exploring the difluoromethylene (CF2) group as a conformational constraint in macrocyclic musk lactones

Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674.

Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

Hyperconjugation Is the Source of Helicity in Perfluorinated n-Alkanes

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid†

Identification of fluorinases from streptomyces sp MA37, norcardia brasiliensis, and actinoplanes sp N902-109 by genome mining

Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus ⬇️

Inter- and intramolecular CF···co interactions on aliphatic and cyclohexane carbonyl derivatives

Interaction of B12F122- with All-cis 1,2,3,4,5,6 Hexafluorocyclohexane in the Gas Phase

Janus Face Aspect of All-cis 1,2,3,4,5,6-Hexafluorocyclohexane Dictates Remarkable Anion and Cation Interactions In the Gas Phase.

Last-Step Enzymatic [(18) F]-Fluorination of Cysteine-Tethered RGD Peptides Using Modified Barbas Linkers

Lewis acid-promoted hydrofluorination of alkynyl sulfides to generate α-fluorovinyl thioethers.

Metabolism and hydrophilicity of the polarised 'Janus face' all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery.

Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.

Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes.

Organic chemistry on surfaces: Direct cyclopropanation by dihalocarbene addition to vinyl terminated self-assembled monolayers (SAMs)

Organo-fluorine chemistry III.

Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring.

Particularly strong C–H⋯π interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane

Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane

Probing the helical integrity of multivicinal all-syn-fluoro alkanes

Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells.

Stepwise preparation of all-cis 1,3,4-trifluoro-2-phenylcyclohexane, avoiding a phenonium intermediate

Stereochemical outcomes of C-F activation reactions of benzyl fluoride.

Stereoselective alpha-fluoroamide and alpha-fluoro-gamma-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement.

Supramolecular packing of alkyl substituted Janus face all-cis 2,3,4,5,6-pentafluorocyclohexyl motifs

Synthesis and elaboration of all-cis-1,2,4,5-tetrafluoro-3-phenylcyclohexane: a polar cyclohexane motif

Synthesis and structure of large difluoromethylene containing alicycles by ring closing metathesis (RCM).

Synthesis of aryl α,α-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl α,α-difluoro oxyethers

Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes

The Synthesis and Evaluation of Fluoro-, Trifluoromethyl-, and Iodomuscimols as GABA Agonists.

The difluoromethylene (CF2) group in aliphatic chains: Synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups

The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes.

The rare fluorinated natural products and biotechnological prospects for fluorine enzymology

Total Synthesis of a Reported Fluorometabolite from Streptomyces sp. TC1 Indicates an Incorrect Assignment. The Isolated Compound Did Not Contain Fluorine

Two 3'-O-β-glucosylated nucleoside fluorometabolites related to nucleocidin in Streptomyces calvus ⬇️

Unexpected α,α'-difluoroethers from Ag(i)F and N-bromosuccinimide reactions of dibenzo[a,e]cyclooctatetraene