Lista de obras - Dirk Jochmans - Dominio Público Uruguay

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

scientific article published on 11 June 2019

A novel high-throughput cellular screening assay for the discovery of HIV-1 integrase inhibitors.

artículo científico publicado en 2011

A novel kindred with inherited STAT2 deficiency and severe viral illness

artículo científico publicado en 2017

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE

scientific article published on 28 April 2012

Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411

artículo científico publicado en 2023

Antiviral Activity of Favipiravir (T-705) against a Broad Range of Paramyxoviruses In Vitro and against Human Metapneumovirus in Hamsters

artículo científico publicado en 2016

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

artículo científico publicado en 2017

Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection

artículo científico publicado en 2017

Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies

artículo científico publicado en 2015

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

artículo científico publicado en 2015

Differential Antiviral Activities of RSV Inhibitors in Human Airway Epithelium

Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.

artículo científico publicado en 2018

Difluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

artículo científico publicado en 2011

Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery

artículo científico publicado en 2016

Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.

artículo científico publicado en 2013

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

artículo científico publicado en 2021

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines

artículo científico publicado en 2019

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent

artículo científico publicado en 2008

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones.

artículo científico publicado en 2018

Intervention strategies for emerging viruses: use of antivirals

artículo científico publicado en 2013

MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV.

artículo científico publicado en 2012

Mannitol treatment is not effective in therapy of rabies virus infection in mice

artículo científico publicado en 2017

Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".

artículo científico publicado en 2008

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

artículo científico publicado en 2014

New HSV-1 Anti-Viral 1'-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety

scientific article published on 03 July 2019

Norovirus: targets and tools in antiviral drug discovery

artículo científico

Novel HIV-1 reverse transcriptase inhibitors.

artículo científico publicado en 2008

Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells.

artículo científico publicado en 2010

Progress in human picornavirus research: New findings from the AIROPico consortium

artículo científico publicado en 2018

Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus

artículo científico publicado en 2014

Pyrimethamine inhibits rabies virus replication in vitro

artículo científico publicado en 2018

Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication

artículo científico publicado en 2013

Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors

artículo científico publicado en 2008

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

scientific article published on 22 October 2020

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

artículo científico publicado en 2020

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

artículo científico publicado en 2014

Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.

artículo científico publicado en 2010

The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon

artículo científico publicado en 2014

The path towards effective antivirals against rabies.

artículo científico publicado en 2017

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.

artículo científico publicado en 2016

The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model

artículo científico publicado en 2013

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

artículo científico publicado en 2022

Lista de obras de Dirk Jochmans

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

A novel high-throughput cellular screening assay for the discovery of HIV-1 integrase inhibitors.

A novel kindred with inherited STAT2 deficiency and severe viral illness

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE

Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411

Antiviral Activity of Favipiravir (T-705) against a Broad Range of Paramyxoviruses In Vitro and against Human Metapneumovirus in Hamsters

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection

Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

Differential Antiviral Activities of RSV Inhibitors in Human Airway Epithelium

Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.

Difluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery

Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones.

Intervention strategies for emerging viruses: use of antivirals

MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV.

Mannitol treatment is not effective in therapy of rabies virus infection in mice

Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

New HSV-1 Anti-Viral 1'-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety

Norovirus: targets and tools in antiviral drug discovery

Novel HIV-1 reverse transcriptase inhibitors.

Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells.

Progress in human picornavirus research: New findings from the AIROPico consortium

Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus

Pyrimethamine inhibits rabies virus replication in vitro

Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication

Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.

The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon

The path towards effective antivirals against rabies.

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.

The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses