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Lista de obras de Jeffrey Milbrandt

A genetic method for defining DNA-binding domains: application to the nuclear receptor NGFI-B

artículo científico publicado en 1993

A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the growth of kidneys and partially rescues enteric nervous system development in Ret-d

artículo científico publicado en 2005

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration

artículo científico publicado en 2012

A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

artículo científico publicado en 1987

A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.

artículo científico

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

artículo científico publicado en 2003

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.

artículo científico publicado en 2006

A transcription factor for cold sensation!

artículo científico publicado en 2005

AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development

artículo científico publicado en 2009

Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.

artículo científico publicado en 2013

Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre-Expressing Neurons

artículo científico publicado en 2017

Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

artículo científico publicado en 2007

Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations

artículo científico publicado en 2007

Amplification of a cloned Chinese hamster dihydrofolate reductase gene after transfer into a dihydrofolate reductase-deficient cell line

artículo científico publicado en 1983

An Egr-1 master switch for arteriogenesis: studies in Egr-1 homozygous negative and wild-type animals.

artículo científico publicado en 2005

An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

artículo científico publicado en 2016

An in vitro assay to study induction of the regenerative state in sensory neurons

artículo científico publicado en 2014

An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury

artículo científico publicado en 2013

Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons.

artículo científico publicado en 2008

Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11

scientific journal article

Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization

artículo científico publicado en 1997

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

artículo científico publicado en 2016

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

artículo científico publicado en 2010

Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants

artículo científico publicado en 2015

Characterization of the Circadian System of NGFI-A and NGFI-A/NGFI-B Deficient Mice ⬇️

artículo científico publicado el 1 de agosto de 1998

Characterization of the Promoter of SF-1, an Orphan Nuclear Receptor Required for Adrenal and Gonadal Development

article

Cloning of the initiation region of a mammalian chromosomal replicon.

artículo científico publicado en 1983

Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.

artículo científico publicado en 2007

Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.

artículo científico publicado en 2009

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

artículo científico publicado en 2022

Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat

artículo científico publicado en 1993

Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems

artículo científico publicado en 2012

Differential activation of NGF receptor and early response genes in neural crest-derived cells

artículo científico publicado el 1 de marzo de 1992

Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction

artículo científico publicado en 2011

Differential regulation of the transcriptional activity of the orphan nuclear receptor NGFI-B by membrane depolarization and nerve growth factor

artículo científico publicado en 1997

Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.

artículo científico publicado en 2005

Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy

scientific article published on 23 November 2019

Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies

scientific journal article

Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development.

artículo científico publicado en 2003

Dynamics of neural crest-derived cell migration in the embryonic mouse gut.

artículo científico publicado en 2004

EGR1 target genes in prostate carcinoma cells identified by microarray analysis.

artículo científico

EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression.

artículo científico publicado en 2001

Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis

artículo científico publicado en 2004

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

artículo científico publicado en 2015

Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse

artículo científico publicado en 1999

Expression profiles provide insights into early malignant potential and skeletal abnormalities in multiple endocrine neoplasia type 2B syndrome tumors.

artículo científico publicado en 2004

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

artículo científico publicado en 2016

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

artículo científico publicado en 2002

Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies.

artículo científico publicado en 1999

GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

artículo científico publicado en 1998

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family ⬇️

artículo científico publicado el 12 de mayo de 1998

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

scientific article published on 14 January 2019

Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation

scientific journal article

Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A

scientific article published on 01 April 1995

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation

scientific article published on 04 September 2020

Homozygous deletion of early growth response 1 gene and critical limb ischemia after vascular ligation in mice: evidence for a central role in vascular homeostasis.

artículo científico publicado en 2004

Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery

artículo científico publicado en 2001

Identifying DNA-Binding Sites and Analyzing DNA-Binding Domains Using a Yeast Selection System

Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations

artículo científico publicado en 2002

Image-based Screening Identifies Novel Roles for IκB Kinase and Glycogen Synthase Kinase 3 in Axonal Degeneration ⬇️

artículo científico publicado el 17 de junio de 2011

In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter

artículo científico publicado en 2002

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

artículo científico publicado en 2004

Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis

scientific article published on 16 October 2000

Lipid rafts in neuronal signaling and function.

artículo científico publicado en 2002

Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)

scientific journal article

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.

artículo científico publicado en 2017

Measuring transcription factor binding and gene expression using barcoded self-reporting transposon calling cards and transcriptomes

artículo científico publicado en 2022

Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule

artículo científico publicado en 1997

Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions.

artículo científico publicado en 2010

Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.

artículo científico publicado en 2014

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

artículo científico publicado en 1981

Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.

artículo científico publicado en 2007

MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes

artículo científico publicado en 2011

Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases

artículo científico publicado en 1998

Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.

artículo científico publicado en 2007

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons

artículo científico publicado en 2014

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

artículo científico publicado en 2010

Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

scientific journal article

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

artículo científico publicado en 1996

NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.

artículo científico publicado en 2007

NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons.

artículo científico publicado en 2002

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.

artículo científico publicado en 2016

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.

artículo científico publicado en 2017

Nab proteins are essential for peripheral nervous system myelination

scientific journal article

Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain

artículo científico publicado en 1998

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

artículo científico publicado en 2007

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

artículo científico publicado en 1988

Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent

artículo científico publicado en 2004

Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C ⬇️

artículo científico publicado el 15 de mayo de 1992

Neurturin and GDNF Promote Proliferation and Survival of Enteric Neuron and Glial Progenitorsin Vitro ⬇️

artículo científico publicado el 1 de agosto de 1998

Neurturin and persephin promote the survival of embryonic basal forebrain cholinergic neurons in vitro

artículo científico publicado en 2003

Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3

artículo científico publicado en 1997

Neurturin-Deficient Mice Develop Dry Eye and Keratoconjunctivitis Sicca ⬇️

artículo científico publicado el 1 de octubre de 2003

Nicotinamide adenine dinucleotide (NAD)–regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus ⬇️

artículo científico publicado el 24 de noviembre de 2010

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

artículo científico publicado en 2011

Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide

artículo científico publicado en 2009

Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth.

artículo científico publicado en 1996

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy

artículo científico publicado en 2016

Novel mutants of NAB corepressors enhance activation by Egr transactivators

artículo científico publicado en 1998

Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1 ⬇️

artículo científico publicado el 1 de mayo de 1998

Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage

artículo científico publicado en 1997

Organization of a Chinese hamster ovary dihydrofolate reductase gene identified by phenotypic rescue

artículo científico publicado en 1983

Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors

artículo científico publicado el 3 de abril de 1992

Persephin, a novel neurotrophic factor related to GDNF and neurturin

artículo científico publicado en 1998

Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor

scientific article published on 01 April 1994

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.

artículo científico publicado en 2016

Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.

artículo científico publicado en 2013

RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice.

artículo científico publicado en 2006

RET signaling is required for survival and normal function of nonpeptidergic nociceptors

scientific journal article

Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP

artículo científico publicado en 2020

Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.

artículo científico publicado en 2009

Resveratrol stimulates AMP kinase activity in neurons

artículo científico publicado en 2007

Role of oxygen consumption in hypoxia protection by translation factor depletion.

artículo científico publicado en 2013

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction

artículo científico publicado en 2015

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation

artículo científico publicado en 2016

SCG10 is a JNK target in the axonal degeneration pathway.

artículo científico publicado en 2012

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions ⬇️

artículo científico publicado el 14 de agosto de 2013

Schwann Cell Mitochondrial Metabolism Supports Long-Term Axonal Survival and Peripheral Nerve Function ⬇️

artículo científico publicado el 13 de julio de 2011

Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.

artículo científico publicado en 2016

Selective contribution of Egr1 (zif/268) to persistent inflammatory pain

scientific article published on 01 January 2005

Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3

artículo científico publicado en 1998

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

artículo científico publicado en 2011

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

scientific journal article

Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor

artículo científico publicado en 1989

TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity

artículo científico publicado en 2000

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.

artículo científico publicado en 2018

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

artículo científico publicado en 2019

TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance

artículo científico publicado en 2016

TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling.

artículo científico publicado en 2018

The AMPK β2 subunit is required for energy homeostasis during metabolic stress

artículo científico publicado en 2012

The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally

artículo científico publicado en 1990

The Nab2 and Stat6 genes share a common transcription termination region.

artículo científico publicado en 1997

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction ⬇️

artículo científico publicado el 9 de mayo de 2013

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

artículo científico publicado en 2017

The Transcriptional Corepressor NAB2 Blocks Egr-1-Mediated Growth Factor Activation and Angiogenesis

article

The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response facto

artículo científico publicado en 1998

The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty.

artículo científico publicado en 2007

The long and short isoforms of Ret function as independent signaling complexes.

artículo científico publicado en 2002

The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase.

artículo científico publicado en 1993

The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro

artículo científico publicado en 2009

The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis.

artículo científico publicado en 2001

The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression.

artículo científico publicado en 2004

The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma

artículo científico publicado en 2009

The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells

artículo científico publicado en 1998

Tissue factor expression and angiogenesis in human prostate carcinoma

scientific article published on 01 April 2000

Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia ⬇️

artículo científico publicado el 7 de julio de 1998

Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.

artículo científico publicado en 1993

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

artículo científico publicado en 1995

Validation of a next-generation sequencing assay for clinical molecular oncology.

artículo científico publicado en 2013

mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.

artículo científico publicado en 2017

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