Lista de obras - C R Wolf - Dominio Público Uruguay

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

artículo científico publicado en 2008

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

artículo científico publicado en 2013

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

artículo científico publicado en 2007

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor

artículo científico publicado en 2013

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

artículo científico publicado en 2005

Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

artículo científico publicado en 2004

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

artículo científico publicado en 1996

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

artículo científico publicado en 2009

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

artículo científico publicado en 2016

Alterations in rat hepatic drug metabolism during pregnancy and lactation

scientific article published on 01 July 1993

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

artículo científico publicado en 2015

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

artículo científico publicado en 2015

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

scientific article published on 18 October 2016

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

artículo científico publicado en 2015

Aryl hydrocarbon receptor is required for optimal B-cell proliferation.

artículo científico publicado en 2016

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

artículo científico publicado en 2016

Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.

artículo científico publicado en 2011

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

artículo científico publicado en 2006

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo

artículo científico publicado en 2012

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

artículo científico publicado en 2007

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

artículo científico publicado en 2003

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

artículo científico publicado en 2016

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity

artículo científico publicado en 2013

Cytochrome P450 CYP2D6.

artículo científico publicado en 1999

Cytochrome P450s and chemoprevention

scientific article published on 01 February 2000

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

artículo científico publicado en 2014

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

artículo científico publicado en 2015

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

artículo científico publicado en 2015

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

artículo científico publicado en 2008

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

artículo científico publicado en 2014

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

artículo científico publicado en 2001

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity ⬇️

artículo científico publicado el 1 de mayo de 1998

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples

artículo científico publicado en 2007

Disruption of the glutathione transferase pi class genes.

artículo científico publicado en 2005

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

artículo científico publicado en 2008

Engineering of a functional human NADH-dependent cytochrome P450 system

artículo científico publicado en 2001

Epigenetic profiles as defined signatures of xenobiotic exposure

artículo científico

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

artículo científico publicado en 2015

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

artículo científico publicado en 2012

Expression of P450 isoenzymes during rat liver organogenesis

scientific article published on 01 November 1993

Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability

artículo científico publicado en 2006

Generation and utility of genetically humanized mouse models.

artículo científico publicado en 2013

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

artículo científico publicado en 2006

Genetic polymorphisms in xenobiotic metabolism.

artículo científico publicado en 1994

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

artículo científico publicado en 2014

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

artículo científico publicado en 2012

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

artículo científico publicado en 2008

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

artículo científico publicado en 2007

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

artículo científico publicado en 2014

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

artículo científico publicado en 2006

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

artículo científico publicado en 1993

Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)

artículo científico publicado en 1993

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

artículo científico publicado en 2010

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

artículo científico publicado en 2011

Illuminating Role of CYP1A1 in Skin Function

artículo científico publicado en 2008

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

artículo científico publicado en 2006

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

artículo científico publicado en 2006

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

artículo científico publicado en 2014

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

artículo científico publicado en 2003

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

artículo científico publicado en 2011

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

artículo científico publicado en 2012

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

artículo científico publicado en 2007

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

artículo científico publicado en 2003

Knockout mice in xenobiotic metabolism

artículo científico publicado en 2003

Lactational transfer of 2,4,5,2',4',5'-hexachlorobiphenyl but not 3,4,3',4'-tetrachlorobiphenyl, induces neonatal CYP4A1

artículo científico publicado en 1993

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

artículo científico publicado en 2016

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

artículo científico publicado en 2002

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

artículo científico publicado en 2009

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy.

artículo científico publicado en 2007

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review

scientific article published on 21 October 2009

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

artículo científico publicado en 2008

Metabolic polymorphisms and cancer susceptibility.

artículo científico publicado en 1995

Metabolism of [3-14C] coumarin by human liver microsomes

artículo científico publicado en 1994

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

artículo científico publicado en 2015

Molecular genetics of the human cytochrome P450-dependent monooxygenases.

artículo científico publicado en 1992

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

artículo científico publicado en 2008

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

artículo científico publicado en 2002

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

artículo científico publicado en 2012

Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.

artículo científico publicado en 2016

Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

article

Perspective on the application of pharmacogenomics in the treatment of cancer.

artículo científico publicado en 2009

Pharmacogenetics

scientific article published on 01 January 1999

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

artículo científico publicado en 2004

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors

artículo científico publicado en 2014

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.

artículo científico publicado en 2014

Pi-class glutathione S-transferase: regulation and function.

artículo científico publicado en 1998

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

artículo científico publicado en 2008

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.

artículo científico publicado en 2003

Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.

artículo científico publicado en 2010

Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.

artículo científico publicado en 2003

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver.

artículo científico publicado en 2015

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours ⬇️

artículo científico publicado el 28 de junio de 2011

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line

scientific article published on 31 May 2011

Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation.

artículo científico publicado en 2003

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo.

artículo científico publicado en 2006

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

artículo científico publicado en 2011

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse

artículo científico publicado en 2005

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

artículo científico publicado en 2007

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant

artículo científico publicado en 2012

Science, medicine, and the future: Pharmacogenetics

artículo científico publicado en 2000

Spatial monitoring of toxicity in HMOX-LacZ transgenic mice.

artículo científico publicado en 2010

Spatial p21 expression profile in the mid-term mouse embryo.

artículo científico publicado en 2010

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease.

artículo científico publicado en 2012

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

artículo científico publicado en 2000

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

artículo científico publicado en 2005

The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s

artículo científico publicado en 2011

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.

artículo científico publicado en 2005

The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells ⬇️

artículo científico publicado el 15 de noviembre de 2011

The usage of a three-compartment model to investigate the metabolic differences between hepatic reductase null and wild-type mice.

artículo científico publicado en 2015

Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

scientific article published on 01 February 1996

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

artículo científico publicado en 2009

Use of transgenic animals in understanding molecular mechanisms of toxicity.

artículo científico publicado en 1998

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

article

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

artículo científico publicado en 2005

p21-LacZ reporter mice reflect p53-dependent toxic insult

article

Lista de obras de C R Wolf

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

Alterations in rat hepatic drug metabolism during pregnancy and lactation

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

Aryl hydrocarbon receptor is required for optimal B-cell proliferation.

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity

Cytochrome P450 CYP2D6.

Cytochrome P450s and chemoprevention

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity ⬇️

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples

Disruption of the glutathione transferase pi class genes.

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

Engineering of a functional human NADH-dependent cytochrome P450 system

Epigenetic profiles as defined signatures of xenobiotic exposure

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

Expression of P450 isoenzymes during rat liver organogenesis

Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability

Generation and utility of genetically humanized mouse models.

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

Genetic polymorphisms in xenobiotic metabolism.

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Illuminating Role of CYP1A1 in Skin Function

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

Knockout mice in xenobiotic metabolism

Lactational transfer of 2,4,5,2',4',5'-hexachlorobiphenyl but not 3,4,3',4'-tetrachlorobiphenyl, induces neonatal CYP4A1

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy.

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

Metabolic polymorphisms and cancer susceptibility.

Metabolism of [3-14C] coumarin by human liver microsomes

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

Molecular genetics of the human cytochrome P450-dependent monooxygenases.

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.