Lista de obras - Ute Hofmann - Dominio Público Uruguay

6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease

artículo científico publicado en 2005

A new [2H]-labelledα-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates

scientific article published on 22 October 2014

A pilot 'window of opportunity' neoadjuvant study of metformin in localised prostate cancer.

artículo científico publicado en 2014

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes

artículo científico publicado en 2009

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells

artículo científico publicado en 2014

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation

artículo científico publicado en 2014

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

artículo científico publicado en 2015

Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death

artículo científico publicado en 2020

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

artículo científico publicado en 2005

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

artículo científico publicado en 1996

Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.

artículo científico publicado en 1996

Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways

artículo científico publicado en 2017

Calcium channel blockers in the management of low-tension and open-angle glaucoma.

artículo científico publicado en 1993

Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

artículo científico publicado en 2013

Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load

artículo científico publicado en 2012

Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein

artículo científico publicado en 2005

Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice

artículo científico publicado en 2004

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

artículo científico publicado en 1996

Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity.

artículo científico publicado en 1998

Chemically induced mouse liver tumors are resistant to treatment with atorvastatin

artículo científico publicado en 2014

Chronopharmacology of intravenous and oral modified release verapamil.

artículo científico publicado en 1999

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists

artículo científico publicado en 2015

Comparative analysis of 3D culture methods on human HepG2 cells

artículo científico publicado en 2016

Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison

artículo científico publicado en 2016

Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry

artículo científico publicado en 2005

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility

artículo científico publicado en 2017

Consequences of rifampicin treatment on propafenone disposition in extensive and poor metabolizers of CYP2D6

scientific article published on 01 October 1999

Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis

artículo científico publicado en 2001

Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency

artículo científico publicado en 2002

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

artículo científico publicado en 2011

Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases.

artículo científico publicado en 2016

Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy?

artículo científico publicado en 2010

Determination of fexofenadine in human plasma and urine by liquid chromatography-mass spectrometry

artículo científico publicado en 2002

Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry

scientific article published on 01 October 2000

Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers

artículo científico publicado en 2002

Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial.

artículo científico publicado en 2014

Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide

artículo científico publicado en 1995

Disposition of Propafenone in a Poor Metabolizer of CYP2D6 With Gilbert's Syndrome

scientific article published on 01 June 2000

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

artículo científico publicado en 2005

Dynamics and control of the central carbon metabolism in hepatoma cells

artículo científico publicado en 2010

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

artículo científico publicado en 1997

Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans

artículo científico publicado en 2006

Enzymatically Modified Low-Density Lipoprotein Is Present in All Stages of Aortic Valve Sclerosis: Implications for Pathogenesis of the Disease

artículo científico publicado en 2015

Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone

artículo científico publicado en 2000

Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data

artículo científico publicado en 2005

Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

artículo científico publicado en 2006

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

artículo científico publicado en 2001

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

artículo científico publicado en 2005

Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers

artículo científico publicado en 2000

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans

artículo científico publicado en 2015

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

artículo científico publicado en 2016

Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins

Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2.

artículo científico publicado en 2016

Heritability of metoprolol and torsemide pharmacokinetics

artículo científico publicado en 2015

High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs

artículo científico publicado en 2012

Highly sensitive and specific gas chromatographic-tandem mass spectrometric method for the determination of trace amounts of antipyrine metabolites in biological material

artículo científico publicado en 1995

Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range

artículo científico publicado en 1999

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations

artículo científico publicado en 2008

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation

artículo científico publicado en 2008

Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine ⬇️

artículo científico publicado el 1 de enero de 1991

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans

artículo científico publicado en 2004

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

artículo científico publicado en 1996

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

artículo científico publicado en 2006

In vitro interaction of codeine and diclofenac.

artículo científico publicado en 2000

Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux

artículo científico publicado en 2007

Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9.

artículo científico publicado en 2015

Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib

artículo científico publicado en 2003

Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion technique

artículo científico publicado en 2013

LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma

artículo científico publicado en 2014

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

artículo científico publicado en 2016

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

artículo científico publicado en 2002

Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death

artículo científico publicado en 2017

Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate

artículo científico publicado en 1993

Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner

artículo científico publicado en 2016

Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS

artículo científico publicado en 2020

Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

artículo científico publicado en 2016

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

artículo científico publicado en 2015

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

scientific journal article

Ocular pharmacokinetics of verapamil in rabbits

artículo científico publicado en 1998

Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis

artículo científico publicado en 2011

P01.31 Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death.

artículo científico publicado en 2017

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis

artículo científico publicado en 2011

Patient education in a 14 month randomized trial fails to improve adherence in ulcerative colitis: Influence of demographic and clinical parameters on non-adherence.

artículo científico

Pentafluorophenyldiazoalkanes as novel derivatization reagents for the determination of sensitive carboxylic acids by gas chromatography—negative-ion mass spectrometry

Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine

artículo científico publicado en 2002

Pharmacokinetics and pharmacodynamics of thiopurines in an in vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay

artículo científico publicado en 2017

Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing

artículo científico publicado en 1999

Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis

scientific article published on 01 April 1999

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

artículo científico publicado en 2017

Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells

artículo científico publicado en 2020

Polymorphic sulphoxidation of carbocisteine

artículo científico publicado en 1990

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes

artículo científico publicado en 2010

Propafenone for the prevention of atrial tachyarrhythmias after cardiac surgery: a randomized, double-blind placebo-controlled trial

artículo científico publicado en 2008

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)

artículo científico publicado en 2011

Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.

artículo científico publicado en 2009

Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na(+)-taurocholate cotransporting polypeptide inhibitor

artículo científico publicado en 2015

RNAi in murine hepatocytes: the agony of choice--a study of the influence of lipid-based transfection reagents on hepatocyte metabolism

artículo científico publicado en 2015

Reconstitution of beta-carotene hydroxylase activity of thermostable CYP175A1 monooxygenase

artículo científico publicado en 2005

Regulation of drug metabolism by the interplay of inflammatory signaling, steatosis, and xeno-sensing receptors in HepaRG cells

artículo científico publicado en 2018

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group

artículo científico publicado en 2008

Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry

artículo científico publicado en 2003

Sensitive quantification of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry

artículo científico publicado en 2005

Simple and sensitive method for the determination of celecoxib in human serum by high-performance liquid chromatography with fluorescence detection

artículo científico publicado en 2002

Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry

artículo científico publicado en 1995

Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry

artículo científico publicado en 2012

Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry

artículo científico publicado en 2013

Syntheses of Metabolites ofS-Carboxymethyl-L-cysteine andS-Methyl-L-cysteine and of Some Isotopically Labelled (2H,13C) Analogues

artículo científico publicado en 1990

Synthesis of novel prostaglandin F2α isomers and structure of an enzymatically formed 13-hydroxyprostaglandin endoperoxide

The impact of thyroid disease on the regulation, expression, and function of ABCB1 (MDR1/P glycoprotein) and consequences for the disposition of digoxin

artículo científico publicado en 2010

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

artículo científico publicado en 2017

UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo

artículo científico publicado en 2009

Lista de obras de Ute Hofmann

6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease

A new [2H]-labelledα-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates

A pilot 'window of opportunity' neoadjuvant study of metformin in localised prostate cancer.

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.

Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways

Calcium channel blockers in the management of low-tension and open-angle glaucoma.

Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load

Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein

Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity.

Chemically induced mouse liver tumors are resistant to treatment with atorvastatin

Chronopharmacology of intravenous and oral modified release verapamil.

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists

Comparative analysis of 3D culture methods on human HepG2 cells

Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison

Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility

Consequences of rifampicin treatment on propafenone disposition in extensive and poor metabolizers of CYP2D6

Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis

Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases.

Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy?

Determination of fexofenadine in human plasma and urine by liquid chromatography-mass spectrometry

Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry

Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers

Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial.

Direct gas chromatographic determination of dechloroethylcyclophosphamide following microsomal incubation of cyclophosphamide

Disposition of Propafenone in a Poor Metabolizer of CYP2D6 With Gilbert's Syndrome

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

Dynamics and control of the central carbon metabolism in hepatoma cells

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans

Enzymatically Modified Low-Density Lipoprotein Is Present in All Stages of Aortic Valve Sclerosis: Implications for Pathogenesis of the Disease

Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone

Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data

Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins

Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2.

Heritability of metoprolol and torsemide pharmacokinetics

High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs

Highly sensitive and specific gas chromatographic-tandem mass spectrometric method for the determination of trace amounts of antipyrine metabolites in biological material

Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation

Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine ⬇️

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

In vitro interaction of codeine and diclofenac.

Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux

Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9.

Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib

Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion technique

LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death

Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate

Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner

Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS

Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity