Lista de obras - Marco Lolli - Dominio Público Uruguay

1,2,5-Oxadiazole analogues of leflunomide and related compounds

artículo científico publicado en 2010

4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade

scientific article published on 25 August 2017

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

artículo científico publicado en 2010

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.

artículo científico publicado en 2017

A novel SWCNT platform bearing DOTA and β-cyclodextrin units. "One shot" multidecoration under microwave irradiation.

artículo científico publicado en 2014

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

artículo científico publicado en 2003

Computational Method for Structure-Based Analysis of SAR Transfer

artículo científico publicado en 2020

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

artículo científico publicado en 2019

Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step

artículo científico publicado en 2017

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

artículo científico publicado en 2017

Detection of O6-butyl- and O6-(4-hydroxybutyl)guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N-nitrosobutyl(4-hydroxybutyl)amine.

artículo científico publicado en 1994

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

scientific article published on 27 June 2019

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

artículo científico publicado en 2019

Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

artículo científico publicado en 2015

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

artículo científico publicado en 2006

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

artículo científico publicado en 2017

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

artículo científico publicado en 2015

Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate

article

N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

artículo científico publicado en 2018

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

scientific article published on 03 January 2012

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

artículo científico publicado en 2018

Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step

artículo científico publicado en 2017

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. ⬇️

artículo científico

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans

artículo científico publicado en 2011

Structure-activity relationships of strigolactones via a novel, quantitative in planta bioassay.

artículo científico publicado en 2018

Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).

artículo científico publicado en 2010

Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption.

artículo científico publicado en 2005

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

artículo científico publicado en 2018

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors.

artículo científico publicado en 2012

Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

artículo científico publicado en 2017

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

scientific article published on 18 April 2019

Lista de obras de Marco Lolli

1,2,5-Oxadiazole analogues of leflunomide and related compounds

4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.

A novel SWCNT platform bearing DOTA and β-cyclodextrin units. "One shot" multidecoration under microwave irradiation.

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

Computational Method for Structure-Based Analysis of SAR Transfer

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

Detection of O6-butyl- and O6-(4-hydroxybutyl)guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N-nitrosobutyl(4-hydroxybutyl)amine.

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate

N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. ⬇️

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans

Structure-activity relationships of strigolactones via a novel, quantitative in planta bioassay.

Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).

Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption.

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors.

Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands