Lista de obras - Mark R Denison - Dominio Público Uruguay

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease ⬇️

artículo científico publicado en 2012

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

artículo científico publicado en 2014

A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing

artículo científico publicado en 2008

ANDES: Statistical tools for the ANalyses of DEep Sequencing

artículo científico publicado en 2010

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

artículo científico publicado en 2020

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing

artículo científico publicado en 2007

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

artículo científico publicado en 2019

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

artículo científico publicado en 2017

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

artículo científico publicado en 2017

Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase.

artículo científico publicado en 2003

Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

scientific article published on 11 September 2013

Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication

artículo científico publicado en 2004

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

artículo científico publicado en 2020

Coronavirus Picornain-like Cysteine Proteinase

Coronavirus Protein Processing and RNA Synthesis Is Inhibited by the Cysteine Proteinase Inhibitor E64d

article

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

artículo científico publicado en 2018

Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation.

artículo científico publicado en 2014

Coronavirus replication complex formation utilizes components of cellular autophagy

artículo científico publicado en 2003

Coronavirus replication does not require the autophagy gene ATG5

artículo científico publicado en 2007

Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity

artículo científico publicado en 2013

Coronaviruses induce entry-independent, continuous macropinocytosis

artículo científico publicado en 2014

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics

artículo científico publicado en 2013

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity

artículo científico publicado en 2011

Determinants of mouse hepatitis virus 3C-like proteinase activity.

artículo científico publicado en 1997

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus

artículo científico publicado en 2011

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

artículo científico publicado en 2020

Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture

artículo científico publicado en 2006

Evaluation of candidate vaccine approaches for MERS-CoV.

artículo científico publicado en 2015

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses

artículo científico publicado en 2013

Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing.

artículo científico publicado en 2010

FATAL FAT EMBOLISM SYNDROME IN A CHILD WITH UNDIAGNOSED HEMOGLOBIN S/Beta+ THALASSEMIA: A Complication of Acute Parvovirus B19 Infection

article by Kathryn A. Kolquist et al published 1 February 1996 in Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association

Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus

artículo científico publicado en 2019

Fitness barriers limit reversion of a proofreading-deficient coronavirus

scientific article published on 27 April 2019

Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly.

artículo científico publicado en 2000

Genetic analysis of Murine hepatitis virus nsp4 in virus replication

artículo científico publicado en 2007

H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT

scientific article published on 12 April 2010

High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.

artículo científico publicado en 2007

Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

artículo científico publicado en 2016

Identification and Characterization of a 65-kDa Protein Processed from the Gene 1 Polyprotein of the Murine Coronavirus MHV-A59

article

Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins

scientific article published on September 2004

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

artículo científico publicado en 2017

Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses.

artículo científico

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

artículo científico publicado en 2018

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.

artículo científico publicado en 2017

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing

artículo científico publicado en 2010

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

artículo científico publicado en 2016

Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication.

artículo científico publicado en 2004

Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events

scientific article published on 01 July 1992

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

artículo científico publicado en 2015

MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication

artículo científico publicado en 2006

Middle East Respiratory Syndrome.

artículo científico publicado en 2017

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

artículo científico publicado en 2013

Molecular targets for the rational design of drugs to inhibit SARS coronavirus

scientific article published on 03 October 2004

Mouse hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

scientific article published on 30 August 2017

Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection.

artículo científico publicado en 2001

Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes

artículo científico publicado en 2000

Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2

scientific article published on 22 April 2020

Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function

artículo científico publicado en 2010

Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization

artículo científico publicado en 2008

Murine hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

artículo científico publicado en 2017

Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive ⬇️

artículo científico publicado el 23 de octubre de 2012

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis

artículo científico publicado en 2007

Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.

artículo científico publicado en 2016

Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication

artículo científico publicado en 2005

Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications

artículo científico publicado en 2014

Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity

artículo científico publicado en 2015

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

artículo científico publicado en 2022

Neonatal renal abscess caused by Staphylococcus aureus ⬇️

artículo científico publicado el 1 de junio de 1991

Novel poxvirus infection in 2 patients from the United States

artículo científico publicado en 2014

Nucleoside analogues for the treatment of coronavirus infections

artículo científico publicado en 2019

Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication

artículo científico publicado en 2007

Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.

artículo científico publicado en 2017

Proofreading-deficient coronaviruses adapt over long-term passage for increased fidelity and fitness without reversion of exoribonuclease-inactivating mutations

artículo científico publicado en 2017

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

scientific article published on 07 July 2020

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

artículo científico publicado en 2020

Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3.

artículo científico publicado en 2006

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

artículo científico publicado en 2003

SARS coronavirus accessory ORFs encode luxury functions

artículo científico publicado en 2006

SARS coronavirus replicase proteins in pathogenesis

artículo científico publicado en 2007

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

artículo científico publicado en 2020

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

artículo científico publicado en 2020

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

artículo científico publicado en 2020

Seeking Membranes: Positive-Strand RNA Virus Replication Complexes

artículo científico publicado en 2008

Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

artículo científico publicado en 2018

Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.

artículo científico publicado en 2015

Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice

artículo científico publicado en 2005

Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update.

artículo científico publicado en 2004

Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice

artículo científico publicado en 2005

Small-Molecule Antiviral β-d--Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

artículo científico publicado en 2019

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

artículo científico publicado en 2008

Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59.

artículo científico publicado en 2002

Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity

artículo científico publicado en 2012

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication

artículo científico publicado en 2006

The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication

artículo científico publicado en 2005

Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses

artículo científico publicado en 2014

Unilateral facial paralysis occurring in an infant with enteroviral otitis media and aseptic meningitis

artículo científico publicado en 2002

Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.

artículo científico publicado en 2010

Viral pharyngitis

artículo científico publicado en 1995

Lista de obras de Mark R Denison

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease ⬇️

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing

ANDES: Statistical tools for the ANalyses of DEep Sequencing

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase.

Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Coronavirus Picornain-like Cysteine Proteinase

Coronavirus Protein Processing and RNA Synthesis Is Inhibited by the Cysteine Proteinase Inhibitor E64d

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation.

Coronavirus replication complex formation utilizes components of cellular autophagy

Coronavirus replication does not require the autophagy gene ATG5

Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity

Coronaviruses induce entry-independent, continuous macropinocytosis

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity

Determinants of mouse hepatitis virus 3C-like proteinase activity.

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture

Evaluation of candidate vaccine approaches for MERS-CoV.

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses

Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing.

FATAL FAT EMBOLISM SYNDROME IN A CHILD WITH UNDIAGNOSED HEMOGLOBIN S/Beta+ THALASSEMIA: A Complication of Acute Parvovirus B19 Infection

Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus

Fitness barriers limit reversion of a proofreading-deficient coronavirus

Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly.

Genetic analysis of Murine hepatitis virus nsp4 in virus replication

H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT

High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.

Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

Identification and Characterization of a 65-kDa Protein Processed from the Gene 1 Polyprotein of the Murine Coronavirus MHV-A59

Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses.

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication.

Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication

Middle East Respiratory Syndrome.

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

Molecular targets for the rational design of drugs to inhibit SARS coronavirus

Mouse hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection.

Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes

Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2

Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function

Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization

Murine hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive ⬇️

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis

Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.

Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication

Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications

Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Neonatal renal abscess caused by Staphylococcus aureus ⬇️

Novel poxvirus infection in 2 patients from the United States

Nucleoside analogues for the treatment of coronavirus infections

Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication

Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.

Proofreading-deficient coronaviruses adapt over long-term passage for increased fidelity and fitness without reversion of exoribonuclease-inactivating mutations

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3.

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus