Lista de obras - Enzo Medico - Dominio Público Uruguay

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits

artículo científico publicado en 2019

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

scientific article published on 07 March 2019

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

artículo científico publicado en 2017

A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart.

artículo científico publicado en 2016

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

scientific article published on 12 December 2019

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells

artículo científico publicado en 2015

A gene trap vector system for identifying transcriptionally responsive genes.

artículo científico publicado en 2001

A genome-wide trap screening procedure for transcriptionally responsive genes

article

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

artículo científico publicado en 2011

A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells

artículo científico publicado en 2007

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models

artículo científico publicado en 2014

BRAF V600E is a determinant of sensitivity to proteasome inhibitors

artículo científico publicado en 2013

Biochemical and immunological properties of the human carcinoma antigen CAR-5 defined by the monoclonal antibody BD-5.

artículo científico publicado en 1989

Cancer and blood coagulation.

artículo científico publicado en 2006

Cardiac concentric hypertrophy promoted by activated Met receptor is mitigated in vivo by inhibition of Erk1,2 signalling with Pimasertib.

artículo científico publicado en 2016

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

artículo científico publicado en 2015

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

scientific article published on 01 August 2020

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.

artículo científico publicado en 2015

Detection of gene communities in multi-networks reveals cancer drivers

artículo científico publicado en 2015

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

artículo científico publicado en 2003

Dysregulation of MS risk genes and pathways at distinct stages of disease

artículo científico publicado en 2017

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

artículo científico publicado en 2016

Electrical conditioning of adipose-derived stem cells in a multi-chamber culture platform

artículo científico publicado en 2014

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

artículo científico publicado en 2012

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

scientific article published on 28 June 2019

Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes

artículo científico publicado en 2008

FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data

artículo científico publicado en 2007

Formalin fixation at low temperature better preserves nucleic acid integrity.

artículo científico publicado en 2011

Gender-based blood transcriptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription

artículo científico publicado en 2011

Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms

artículo científico publicado en 2010

Gene trapping: a multi-purpose tool for functional genomics.

artículo científico publicado en 2003

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

article

High-throughput molecular analysis from leftover of fine needle aspiration cytology of mammographically detected breast cancer.

artículo científico publicado en 2012

IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding.

artículo científico publicado en 2004

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

artículo científico publicado en 2015

IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.

artículo científico publicado en 2018

Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells.

artículo científico publicado en 2013

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

artículo científico publicado en 2018

Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor.

artículo científico publicado en 2009

Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer

artículo científico publicado en 2011

Inhibition of Src impairs the growth of met-addicted gastric tumors.

artículo científico publicado en 2010

Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power

artículo científico publicado en 2018

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

artículo científico publicado en 2017

Isolation and characterization of a spontaneously immortalized multipotent mesenchymal cell line derived from mouse subcutaneous adipose tissue

artículo científico publicado en 2013

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

artículo científico publicado en 2017

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.

artículo científico publicado en 2013

Met-driven invasive growth involves transcriptional regulation of Arhgap12.

artículo científico publicado en 2008

MicroRNA-mRNA interactions underlying colorectal cancer molecular subtypes.

artículo científico publicado en 2015

Mulcom: a multiple comparison statistical test for microarray data in Bioconductor

artículo científico publicado en 2011

Multipotent mesenchymal stem cells from amniotic fluid originate neural precursors with functional voltage-gated sodium channels

artículo científico publicado en 2009

Only a subset of Met-activated pathways are required to sustain oncogene addiction

artículo científico publicado en 2009

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas

artículo científico publicado en 2012

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

artículo científico publicado en 2017

Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study

artículo científico publicado en 2014

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

artículo científico publicado en 2019

Predicting locally advanced rectal cancer response to neoadjuvant therapy with 18F-FDG PET and MRI radiomics features

scientific article published on 13 January 2019

Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.

artículo científico publicado en 2013

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

artículo científico publicado en 2018

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

artículo científico publicado en 2008

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells

scientific article published on 20 August 2019

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

artículo científico publicado en 2018

Search for neuro-endocrine markers (chromogranin A, synaptophysin and VGF) in breast cancers. An integrated approach using immunohistochemistry and gene expression profiling

artículo científico publicado en 2014

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

artículo científico publicado en 2017

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

artículo científico publicado en 2012

Stromal contribution to the colorectal cancer transcriptome.

artículo científico publicado en 2015

The Dilemma of HER2 Double-equivocal Breast Carcinomas: Genomic Profiling and Implications for Treatment

artículo científico publicado en 2018

The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer

artículo científico publicado en 2009

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

artículo científico publicado en 1996

The MET oncogene drives a genetic programme linking cancer to haemostasis

artículo científico publicado en 2005

The MET oncogene is a functional marker of a glioblastoma stem cell subtype.

artículo científico publicado en 2012

The RNA-binding protein ESRP1 promotes human colorectal cancer progression

artículo científico publicado en 2016

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

artículo científico publicado en 2015

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

artículo científico publicado en 2012

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

artículo científico publicado en 2015

The tyrosine kinase receptor met and its ligand HGF are co-expressed and functionally active in HHV-8 positive primary effusion lymphoma.

artículo científico publicado en 2000

Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.

artículo científico publicado en 2012

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.

artículo científico publicado en 2017

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research

artículo científico publicado en 2019

Lista de obras de Enzo Medico

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart.

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells

A gene trap vector system for identifying transcriptionally responsive genes.

A genome-wide trap screening procedure for transcriptionally responsive genes

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models

BRAF V600E is a determinant of sensitivity to proteasome inhibitors

Biochemical and immunological properties of the human carcinoma antigen CAR-5 defined by the monoclonal antibody BD-5.

Cancer and blood coagulation.

Cardiac concentric hypertrophy promoted by activated Met receptor is mitigated in vivo by inhibition of Erk1,2 signalling with Pimasertib.

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.

Detection of gene communities in multi-networks reveals cancer drivers

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

Dysregulation of MS risk genes and pathways at distinct stages of disease

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

Electrical conditioning of adipose-derived stem cells in a multi-chamber culture platform

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes

FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data

Formalin fixation at low temperature better preserves nucleic acid integrity.

Gender-based blood transcriptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription

Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms

Gene trapping: a multi-purpose tool for functional genomics.

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

High-throughput molecular analysis from leftover of fine needle aspiration cytology of mammographically detected breast cancer.

IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding.

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.

Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells.

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor.

Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer

Inhibition of Src impairs the growth of met-addicted gastric tumors.

Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

Isolation and characterization of a spontaneously immortalized multipotent mesenchymal cell line derived from mouse subcutaneous adipose tissue

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.

Met-driven invasive growth involves transcriptional regulation of Arhgap12.

MicroRNA-mRNA interactions underlying colorectal cancer molecular subtypes.

Mulcom: a multiple comparison statistical test for microarray data in Bioconductor

Multipotent mesenchymal stem cells from amniotic fluid originate neural precursors with functional voltage-gated sodium channels

Only a subset of Met-activated pathways are required to sustain oncogene addiction

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Predicting locally advanced rectal cancer response to neoadjuvant therapy with 18F-FDG PET and MRI radiomics features

Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

Search for neuro-endocrine markers (chromogranin A, synaptophysin and VGF) in breast cancers. An integrated approach using immunohistochemistry and gene expression profiling

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

Stromal contribution to the colorectal cancer transcriptome.

The Dilemma of HER2 Double-equivocal Breast Carcinomas: Genomic Profiling and Implications for Treatment

The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

The MET oncogene drives a genetic programme linking cancer to haemostasis

The MET oncogene is a functional marker of a glioblastoma stem cell subtype.

The RNA-binding protein ESRP1 promotes human colorectal cancer progression

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

The tyrosine kinase receptor met and its ligand HGF are co-expressed and functionally active in HHV-8 positive primary effusion lymphoma.

Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research