Lista de obras - Philip D Dunne - Dominio Público Uruguay

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA

artículo científico publicado en 2019

ACE: A Workbench using Evolutionary Genetic Algorithms for analysing association in TCGA Data

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.

artículo científico publicado en 2013

Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study.

artículo científico publicado en 2017

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer.

artículo científico publicado en 2018

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification ⬇️

artículo científico publicado en 2017

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

artículo científico publicado en 2016

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

artículo científico publicado en 2013

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies

artículo científico publicado en 2015

DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.

artículo científico publicado en 2011

Defining the molecular evolution of extrauterine high grade serous carcinoma

scientific article published on 04 September 2019

Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned.

artículo científico

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

artículo científico publicado en 2017

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

artículo científico publicado en 2015

Epithelial-to-mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition

scientific article published on 01 December 2018

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

scientific article published on 28 September 2019

Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer

scientific article published on 06 February 2014

Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt

scientific article published on 23 July 2019

Gene expression profiling of patient-matched initial and recurrent glioblastoma

artículo científico publicado en 2018

Gremlin1 plays a key role in kidney development and renal fibrosis

artículo científico publicado en 2017

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

artículo científico publicado en 2017

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

artículo científico publicado en 2020

Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

artículo científico publicado en 2016

Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

article

In-depth clinical and biological exploration of DNA Damage Immune Response (DDIR) as a biomarker for oxaliplatin use in colorectal cancer

artículo científico publicado en 2020

Intratumoural Epigenetic Heterogeneity in Early Invasive Colorectal Cancer: A Prognostic Imprint?

artículo científico publicado en 2017

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

artículo científico publicado en 2016

MLH1 mediates PARP-dependent cell death in response to the methylating agent -methyl--nitrosourea

artículo científico publicado en 2010

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

artículo científico publicado en 2017

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.

artículo científico

P04.46 Variable RNA sequencing depth impacts gene signatures and target compound robustness - case study examining brain tumour (glioma) disease progression

PICan: An integromics framework for dynamic cancer biomarker discovery

artículo científico publicado en 2015

Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal cancer cells.

artículo científico publicado en 2012

Prognosis following surgical resection versus local excision of stage pT1 colorectal cancer: A population-based cohort study

artículo científico publicado en 2019

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

artículo científico publicado en 2018

Punctate MLH1 mismatch repair immunostaining in colorectal cancer

artículo científico publicado en 2019

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

artículo científico publicado en 2016

QuPath: Open source software for digital pathology image analysis

artículo científico publicado en 2017

QuPath: Open source software for digital pathology image analysis

Response to Park et al. reply to 'Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study'.

artículo científico publicado en 2017

Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase-induced cardiomyopathy: involvement of mitofusin-2.

artículo científico publicado en 2017

Standardising RNA profiling based biomarker application in cancer-The need for robust control of technical variables ⬇️

artículo científico

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer.

artículo científico publicado en 2016

Stromal Cell PD-L1 Inhibits CD8+ T-cell Antitumor Immune Responses and Promotes Colon Cancer

artículo científico publicado en 2018

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

scientific article published on 19 August 2019

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

artículo científico publicado en 2015

The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

artículo científico publicado en 2020

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

artículo científico publicado en 2018

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

artículo científico publicado en 2016

Tumour invasion and dissemination

artículo científico publicado en 2022

Validation of the systematic scoring of immunohistochemically-stained tumour tissue microarrays using QuPath digital image analysis.

artículo científico publicado en 2018

cudaMap: a GPU accelerated program for gene expression connectivity mapping

artículo científico publicado en 2013

Lista de obras de Philip D Dunne

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA

ACE: A Workbench using Evolutionary Genetic Algorithms for analysing association in TCGA Data

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.

Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study.

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer.

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification ⬇️

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies

DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.

Defining the molecular evolution of extrauterine high grade serous carcinoma

Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned.

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

Epithelial-to-mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer

Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt

Gene expression profiling of patient-matched initial and recurrent glioblastoma

Gremlin1 plays a key role in kidney development and renal fibrosis

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

In-depth clinical and biological exploration of DNA Damage Immune Response (DDIR) as a biomarker for oxaliplatin use in colorectal cancer

Intratumoural Epigenetic Heterogeneity in Early Invasive Colorectal Cancer: A Prognostic Imprint?

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

MLH1 mediates PARP-dependent cell death in response to the methylating agent -methyl--nitrosourea

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.

P04.46 Variable RNA sequencing depth impacts gene signatures and target compound robustness - case study examining brain tumour (glioma) disease progression

PICan: An integromics framework for dynamic cancer biomarker discovery

Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal cancer cells.

Prognosis following surgical resection versus local excision of stage pT1 colorectal cancer: A population-based cohort study

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies ⬇️

Punctate MLH1 mismatch repair immunostaining in colorectal cancer

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

QuPath: Open source software for digital pathology image analysis

QuPath: Open source software for digital pathology image analysis

Response to Park et al. reply to 'Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study'.

Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase-induced cardiomyopathy: involvement of mitofusin-2.

Standardising RNA profiling based biomarker application in cancer-The need for robust control of technical variables ⬇️

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer.

Stromal Cell PD-L1 Inhibits CD8+ T-cell Antitumor Immune Responses and Promotes Colon Cancer

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

Tumour invasion and dissemination

Validation of the systematic scoring of immunohistochemically-stained tumour tissue microarrays using QuPath digital image analysis.

cudaMap: a GPU accelerated program for gene expression connectivity mapping