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Lista de obras de David McGowan

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

artículo científico publicado en 2009

2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus

scientific article published on 17 July 2018

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library

artículo científico publicado en 2017

Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists

artículo científico publicado en 2018

Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region

artículo científico publicado en 2019

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase

artículo científico publicado en 2013

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

artículo científico publicado en 2007

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity

artículo científico publicado en 2006

Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors.

artículo científico publicado en 2008

Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.

artículo científico publicado en 2008

Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.

artículo científico publicado en 2017

Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity

scientific article published on 01 August 2006

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

artículo científico publicado en 2016

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

scientific article published on 11 December 2020

Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.

artículo científico publicado en 2008

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