Lista de obras - Adrián Llerena - Dominio Público Uruguay

A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project.

artículo científico publicado en 2015

A combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances.

artículo científico publicado en 2014

A rapid and simple LC–MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity

artículo científico publicado en 2014

A tribute to josé maría ("chema") cantú.

artículo científico publicado en 2014

ABCB1 gene polymorphisms and violent suicide attempt among survivors.

artículo científico publicado en 2014

ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study

artículo científico publicado en 2011

Acetylator polymorphism in Parkinson's disease

artículo científico publicado en 1989

Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers

artículo científico publicado en 2016

An Appeal to the Global Health Community for a Tripartite Innovation: An "Essential Diagnostics List," "Health in All Policies," and "See-Through 21(st) Century Science and Ethics".

artículo científico publicado en 2015

An Open Letter in Support of Transformative Biotechnology and Social Innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016.

artículo científico publicado en 2016

Analysis of diclofenac and its metabolites by high-performance liquid chromatography: relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios.

artículo científico publicado en 2003

Antipsychotic drugs and QTc prolongation: the potential role of CYP2D6 genetic polymorphism.

artículo científico publicado en 2007

Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms.

artículo científico publicado en 2008

Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis.

artículo científico publicado en 1989

Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs.

artículo científico publicado en 2007

Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population

artículo científico publicado en 2012

CYP2C9 allele frequency differences between populations of Mexican-Mestizo, Mexican-Tepehuano, and Spaniards.

artículo científico publicado en 2010

CYP2C9 gene and susceptibility to major depressive disorder.

artículo científico publicado en 2003

CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy

artículo científico publicado en 2015

CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico

article

CYP2D6 genetic polymorphism and psychiatry patients' hospitalization period

artículo científico publicado en 2013

CYP2D6 genetic polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas

artículo científico publicado en 2014

CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans

artículo científico publicado en 2010

CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

artículo científico publicado en 2011

CYP2D6 polymorphism and mental and personality disorders in suicide attempters

artículo científico publicado en 2014

CYP2D6 polymorphism in patients with eating disorders

artículo científico publicado en 2010

CYP2D6 poor metabolizer status might be associated with better response to risperidone treatment

artículo científico publicado en 2013

CYP2D6 variation, behaviour and psychopathology: implications for pharmacogenomics-guided clinical trials

artículo científico publicado en 2014

CYP2D6Polymorphism and Mental and Personality Disorders in Suicide Attempters

article published in 2013

CYP450 genotype and pharmacogenetic association studies: a critical appraisal

article

Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: pharmacogenetic implications

article

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

artículo científico publicado en 2015

Clinical drug-drug interactions: focus on venlafaxine.

artículo científico publicado en 2015

Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs.

artículo científico publicado en 2006

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

artículo científico publicado en 1994

Clozapine withdrawal symptoms after change to sertindole in a schizophrenic patient

artículo científico publicado en 2000

Cumplimiento farmacológico en el tratamiento de la hipertensión arterial. Revisión de los estudios publicados entre los años 1975 y 2011

artículo científico publicado en 2012

Cytochrome P450 genetic polymorphisms of Mexican indigenous populations.

artículo científico

DEBRISOQUINE HYDROXYLATION PHENOTYPES IN HEALTHY VOLUNTEERS

scientific article published in The Lancet

Debrisoquin and mephenytoin hydroxylation phenotypes and CYP2D6 genotype in patients treated with neuroleptic and antidepressant agents

artículo científico publicado en 1993

Debrisoquine oxidation in schizophrenic patients treated with neuroleptics

Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection

artículo científico publicado en 2001

Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship

artículo científico publicado en 2005

Determination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients.

artículo científico publicado en 2003

Determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography: application to the evaluation of CYP2D6 drug interactions.

artículo científico publicado en 2003

Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes

article

Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use

scientific article published on 01 October 2005

Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use.

artículo científico publicado en 2005

Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms

artículo científico publicado en 1994

Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation.

artículo científico publicado en 1993

Editorial [Hot Topic: Pharmacogenetic and Pharmacogenomics (Guest Editors: A. LLerena and J. Licinio) ]

artículo científico publicado en 2006

Editorial: CPPM 2013 Onward: Building a Socio-Technical GPS for Global Personalized Medicine – A Welcome to Editors-In-Chief Adrian LLerena (Spain) and Ross A. McKinnon (Australia)

article

Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions.

artículo científico publicado en 2004

Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.

artículo científico publicado en 2001

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment

artículo científico publicado en 2016

Erratum to: “Schizophrenia and tobacco smoking in a Spanish psychiatric hospital” [Schizophr. Res. 58 (2002) 323–327]

article

Erratum: CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients

scholarly article published in Molecular Psychiatry

Estudio farmacogenético del polimorfismo metabólico de la debrisoquina (CYP2D6) en la población cubana en relación con la española

artículo científico publicado en 2007

Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans

artículo científico publicado en 2014

Evaluating a newly developed pharmacogenetic array: screening in a Spanish population.

artículo científico publicado en 2010

Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis.

artículo científico publicado en 2017

First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma

scientific article published on 01 January 2014

Fixed combinations of neuroleptics with antidepressants: potential risks and estimation of use.

artículo científico publicado en 1994

Frequency of S-mephenytoin hydroxylation deficiency in 373 spanish subjects compared to other Caucasian populations

article

Genetic variability of CYP2C92 and CYP2C93 in seven indigenous groups from Mexico.

artículo científico publicado en 2016

Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype

artículo científico publicado el 1 de abril de 1992

Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers

artículo científico publicado el 1 de junio de 1992

High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme

High frequency of CYP2D6 ultrarapid metabolizer genotypes in an Ashkenazi Jewish population from Argentina.

artículo científico publicado en 2016

High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies.

artículo científico publicado en 2016

High prevalence of CYP2D6 ultrarapid metabolizers in a mestizo Colombian population in relation to Hispanic mestizo populations

artículo científico publicado en 2020

High-performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients.

artículo científico publicado en 2012

Impact of cytochrome P450 genes on suicide attempt and risk.

artículo científico publicado en 2013

Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele

artículo científico publicado en 2007

Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among Mexican tepehuanos and mestizos.

artículo científico publicado en 2010

Influence of admixture components on CYP2C9*2 allele frequency in eight indigenous populations from Northwest Mexico.

artículo científico publicado en 2013

Interethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations.

artículo científico publicado en 2013

Interethnic relationships of CYP2D6 variants in native and Mestizo populations sharing the same ecosystem.

artículo científico publicado en 2015

Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.

artículo científico publicado en 2014

Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics)

artículo científico publicado en 2016

Interethnic variation of CYP2C19 alleles, 'predicted' phenotypes and 'measured' metabolic phenotypes across world populations.

artículo científico publicado en 2015

Intuitive pharmacogenetic dosing of risperidone according to CYP2D6 phenotype extrapolated from genotype in a cohort of first episode psychosis patients

artículo científico publicado en 2017

La Tertulia del Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo

artículo científico publicado en 2008

Liver enzyme abnormalities during antipsychotic treatment: a case report of risperidone-associated hepatotoxicity

scientific article published on 01 January 2014

Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender

Low frequency of CYP2D6 poor metabolizers among schizophrenia patients

article

Lower frequency of CYP2C9*2 in Mexican-Americans compared to Spaniards.

artículo científico publicado en 2004

MDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers.

artículo científico publicado en 2013

Metabolic phenotype prediction from genotyping data: a bottleneck for the implementation of pharmacogenetics in drug development and clinical practice.

artículo científico publicado en 2015

Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe ⬇️

artículo científico publicado el 1 de agosto de 1997

Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach.

artículo científico publicado en 2015

Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms

article

Oxidative polymorphism of debrisoquine in Parkinson's disease

artículo científico publicado en 1990

Patterns of drug treatment of schizophrenic patients in Estonia, Spain and Sweden

artículo científico publicado en 1995

Pharmacogenetic Studies of Suicide: Potential Relevance of Main Polymorphic CYPs and ABCB1

Pharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response.

artículo científico publicado en 2014

Pharmacogenetic research activity in Central America and the Caribbean: a systematic review

artículo científico publicado en 2016

Pharmacogenetic study of antipsychotic induced acute extrapyramidal symptoms in a first episode psychosis cohort: role of dopamine, serotonin and glutamate candidate genes

artículo científico publicado en 2016

Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America.

artículo científico publicado en 2016

Pharmacogenetics and therapeutic drug monitoring of fluoxetine in a real-world setting: A PK/PD analysis of the influence of (non-)genetic factors

artículo científico publicado en 2019

Pharmacogenetics in Central American healthy volunteers: interethnic variability

artículo científico

Pharmacogenetics in Latin American populations: regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders

artículo científico publicado en 2012

Pharmacogenetics of adverse reactions to antiepileptic drugs.

artículo científico

Pharmacogenetics of clinical response to risperidone.

artículo científico publicado en 2013

Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.

artículo científico publicado en 2009

Pharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine.

artículo científico publicado en 2011

Pharmacogenomic information in drug labels: European Medicines Agency perspective.

artículo científico publicado en 2015

Pharmacogenomics and Personality: Role of CYP2D6 and Implications for Psychopathology

article published in 2010

Pharmacogenomics and personalized medicine in clinical practice

artículo científico publicado en 2011

Pharmacogenomics education: International Society of Pharmacogenomics recommendations for medical, pharmaceutical, and health schools deans of education.

artículo científico publicado en 2005

Pharmacogenomics in pain treatment

artículo científico publicado en 2016

Pharmacokinetic Interaction of Fluvoxamine and Thioridazine in Schizophrenic Patients

artículo científico publicado en 1999

Polymorphic Oxidation of Debrisoquine in Bladder Cancer

artículo científico publicado en 1990

Polymorphic oxidation of debrisoquine in lung cancer patients

artículo científico publicado en 1991

Polymorphic oxidation of debrisoquine in women with breast cancer

artículo científico publicado en 1991

Population pharmacogenetics and global health

article

Population pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014)

artículo científico publicado en 2015

Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen.

artículo científico publicado en 2016

Present status and perspective of pharmacogenetics in Mexico

artículo científico

Progress in pharmacogenetics: consortiums and new strategies

artículo científico publicado en 2016

QTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy.

artículo científico publicado en 2002

QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients

artículo científico publicado en 2002

QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations.

artículo científico publicado en 2004

Ready to put metadata on the post-2015 development agenda? Linking data publications to responsible innovation and science diplomacy

artículo científico publicado en 2014

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study

artículo científico publicado en 2019

References used in a Drug Information Centre

scientific article published on 01 January 1995

Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients.

artículo científico publicado en 2004

Relationship between personality and debrisoquine hydroxylation capacity

article

Relationship between the CYP2C9 IVS8-109A>T polymorphism and high losartan hydroxylation in healthy Ecuadorian volunteers

scientific article published on 01 August 2014

Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population

artículo científico publicado en 2020

Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients.

artículo científico publicado en 2009

Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population

Reproducibility over Time of Mephenytoin and Debrisoquine Hydroxylation Phenotypes

artículo científico publicado en 1993

Reproducibility over time of the urinary diclofenac/4'-OH diclofenac ratio among different CYP2C9 genotypes

artículo científico publicado en 2003

Research Highlights

artículo científico publicado en 2013

Research Highlights

Research Highlights: Novel CYP2C9 genetic polymorphisms and assessment of their impact on hydroxylation capacity

artículo científico publicado en 2014

Schizophrenia and tobacco smoking in a Spanish psychiatric hospital.

artículo científico publicado en 2002

Schizophrenia and tobacco smoking in a Spanish psychiatric hospital.

artículo científico publicado en 2003

Schizophrenia stigma among medical and nursing undergraduates

artículo científico publicado en 2002

Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach.

artículo científico publicado en 2016

Strengths and weaknesses of pharmacogenetic studies of antipsychotic drugs: the potential value of the PEPs study.

artículo científico publicado en 2012

Success stories in genomic medicine from resource-limited countries

artículo científico publicado en 2015

The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans.

artículo científico publicado en 2015

The Underlying Traits of the Karolinska Scales of Personality (KSP)

The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients

artículo científico publicado en 2020

Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography

artículo científico publicado en 2017

Third Santorini conference pharmacogenomics workshop report: “Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?”

artículo científico publicado en 2007

To Genotype or Phenotype for Personalized Medicine? CYP450 Drug Metabolizing Enzyme Genotype-Phenotype Concordance and Discordance in the Ecuadorian Population

artículo científico publicado en 2016

Translating biotechnology to knowledge-based innovation, peace, and development? Deploy a Science Peace Corps--an open letter to world leaders

artículo científico publicado en 2014

Use of pharmacogenetics in bioequivalence studies to reduce sample size: an example with mirtazapine and CYP2D6.

artículo científico publicado en 2012

Use of the Mesoridazine/Thioridazine Ratio as a Marker for CYP2D6 Enzyme Activity

artículo científico publicado en 2000

Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers

artículo científico

What is the future of pharmacogenomics in pain management?

artículo científico publicado en 2016

Worldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes.

artículo científico publicado en 2015

[Interaction between prajmaline and metoprotol: a possible pharmacogenetic explanation]

artículo científico publicado en 1997

[Optimizing pharmacologic therapy for the elderly]

artículo científico publicado en 2001

[Prevalence of polydipsia and water intoxication in psychiatric inpatients]

scientific article published on 01 September 2001

Lista de obras de Adrián Llerena

A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project.

A combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances.

A rapid and simple LC–MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity

A tribute to josé maría ("chema") cantú.

ABCB1 gene polymorphisms and violent suicide attempt among survivors.

ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study

Acetylator polymorphism in Parkinson's disease

Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers

An Appeal to the Global Health Community for a Tripartite Innovation: An "Essential Diagnostics List," "Health in All Policies," and "See-Through 21(st) Century Science and Ethics".

An Open Letter in Support of Transformative Biotechnology and Social Innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016.

Analysis of diclofenac and its metabolites by high-performance liquid chromatography: relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios.

Antipsychotic drugs and QTc prolongation: the potential role of CYP2D6 genetic polymorphism.

Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms.

Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis.

Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs.

Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population

CYP2C9 allele frequency differences between populations of Mexican-Mestizo, Mexican-Tepehuano, and Spaniards.

CYP2C9 gene and susceptibility to major depressive disorder.

CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy

CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico

CYP2D6 genetic polymorphism and psychiatry patients' hospitalization period

CYP2D6 genetic polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas

CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans

CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

CYP2D6 polymorphism and mental and personality disorders in suicide attempters

CYP2D6 polymorphism in patients with eating disorders

CYP2D6 poor metabolizer status might be associated with better response to risperidone treatment

CYP2D6 variation, behaviour and psychopathology: implications for pharmacogenomics-guided clinical trials

CYP2D6Polymorphism and Mental and Personality Disorders in Suicide Attempters

CYP450 genotype and pharmacogenetic association studies: a critical appraisal

Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: pharmacogenetic implications

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

Clinical drug-drug interactions: focus on venlafaxine.

Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs.

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

Clozapine withdrawal symptoms after change to sertindole in a schizophrenic patient

Cumplimiento farmacológico en el tratamiento de la hipertensión arterial. Revisión de los estudios publicados entre los años 1975 y 2011

Cytochrome P450 genetic polymorphisms of Mexican indigenous populations.

DEBRISOQUINE HYDROXYLATION PHENOTYPES IN HEALTHY VOLUNTEERS

Debrisoquin and mephenytoin hydroxylation phenotypes and CYP2D6 genotype in patients treated with neuroleptic and antidepressant agents

Debrisoquine oxidation in schizophrenic patients treated with neuroleptics

Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection

Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship

Determination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients.

Determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography: application to the evaluation of CYP2D6 drug interactions.

Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes

Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use

Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use.

Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms

Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation.

Editorial [Hot Topic: Pharmacogenetic and Pharmacogenomics (Guest Editors: A. LLerena and J. Licinio) ]

Editorial: CPPM 2013 Onward: Building a Socio-Technical GPS for Global Personalized Medicine – A Welcome to Editors-In-Chief Adrian LLerena (Spain) and Ross A. McKinnon (Australia)

Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions.

Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment

Erratum to: “Schizophrenia and tobacco smoking in a Spanish psychiatric hospital” [Schizophr. Res. 58 (2002) 323–327]

Erratum: CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients

Estudio farmacogenético del polimorfismo metabólico de la debrisoquina (CYP2D6) en la población cubana en relación con la española

Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans

Evaluating a newly developed pharmacogenetic array: screening in a Spanish population.

Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis.

First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma

Fixed combinations of neuroleptics with antidepressants: potential risks and estimation of use.

Frequency of S-mephenytoin hydroxylation deficiency in 373 spanish subjects compared to other Caucasian populations

Genetic variability of CYP2C9*2 and CYP2C9*3 in seven indigenous groups from Mexico.

Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype

Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers

High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme

High frequency of CYP2D6 ultrarapid metabolizer genotypes in an Ashkenazi Jewish population from Argentina.

High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies.

High prevalence of CYP2D6 ultrarapid metabolizers in a mestizo Colombian population in relation to Hispanic mestizo populations

High-performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients.

Impact of cytochrome P450 genes on suicide attempt and risk.

Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele

Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among Mexican tepehuanos and mestizos.

Influence of admixture components on CYP2C9*2 allele frequency in eight indigenous populations from Northwest Mexico.

Interethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations.

Interethnic relationships of CYP2D6 variants in native and Mestizo populations sharing the same ecosystem.

Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.

Genetic variability of CYP2C92 and CYP2C93 in seven indigenous groups from Mexico.