Lista de obras - Christine Beeton - Dominio Público Uruguay

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

artículo científico publicado en 2012

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

artículo científico publicado en 2014

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

artículo científico publicado en 2013

Analogs of the Sea Anemone Potassium Channel Blocker ShK for the Treatment of Autoimmune Diseases ⬇️

artículo científico publicado el 1 de octubre de 2011

Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin

artículo científico publicado en 2015

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

artículo científico publicado en 2014

Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes

artículo científico publicado en 2013

CHAPTER 10. Case Study 2: Transforming a Toxin into a Therapeutic: the Sea Anemone Potassium Channel Blocker ShK Toxin for Treatment of Autoimmune Diseases

Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.

artículo científico publicado en 2015

Detection of functional matrix metalloproteinases by zymography.

artículo científico publicado en 2010

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.

artículo científico publicado en 2015

Discovery on Target 2007--CHI's Fifth Annual Conference. Ion channels.

artículo científico publicado en 2007

Drawing blood from rats through the saphenous vein and by cardiac puncture.

artículo científico publicado en 2007

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

artículo científico publicado en 2012

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

artículo científico publicado en 2009

Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.

artículo científico publicado en 2004

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

artículo científico publicado en 2012

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

artículo científico publicado en 2011

Imaging effector memory T cells in the ear after induction of adoptive DTH.

artículo científico publicado en 2008

Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis.

artículo científico publicado en 2007

Induction and monitoring of active delayed type hypersensitivity (DTH) in rats.

artículo científico publicado en 2007

Ion channels and anti-cancer immunity.

scientific article published on 03 February 2014

Ion channels and demyelination: basis of a treatment of experimental autoimmune encephalomyelitis (EAE) by potassium channel blockers

artículo científico publicado en 2004

K+ channels as targets for specific immunomodulation

artículo científico publicado en 2004

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

artículo científico publicado en 2019

KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis.

artículo científico publicado en 2015

KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis.

artículo científico publicado en 2011

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

artículo científico publicado en 2014

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

artículo científico publicado en 2015

Potassium channels as therapeutic targets for autoimmune disorders

artículo científico publicado en 2003

Potassium channels, memory T cells, and multiple sclerosis

artículo científico publicado en 2005

Preparing T cell growth factor from rat splenocytes

artículo científico publicado en 2007

Quantitative measurement of GLUT4 translocation to the plasma membrane by flow cytometry.

artículo científico publicado en 2010

Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers

artículo científico publicado en 2012

Selective blockade of T lymphocyte K+channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis ⬇️

artículo científico publicado el 20 de noviembre de 2001

Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease

artículo científico publicado en 2014

Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis.

artículo científico publicado en 2018

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

artículo científico publicado en 2005

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

artículo científico publicado en 2008

The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion ⬇️

scientific journal article

The impact of the fourth disulfide bridge in scorpion toxins of the α-KTx6 subfamily

artículo científico publicado en 2005

The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

artículo científico publicado en 2005

Lista de obras de Christine Beeton

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation

Analogs of the Sea Anemone Potassium Channel Blocker ShK for the Treatment of Autoimmune Diseases ⬇️

Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes

CHAPTER 10. Case Study 2: Transforming a Toxin into a Therapeutic: the Sea Anemone Potassium Channel Blocker ShK Toxin for Treatment of Autoimmune Diseases

Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.

Detection of functional matrix metalloproteinases by zymography.

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.

Discovery on Target 2007--CHI's Fifth Annual Conference. Ion channels.

Drawing blood from rats through the saphenous vein and by cardiac puncture.

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

Imaging effector memory T cells in the ear after induction of adoptive DTH.

Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis.

Induction and monitoring of active delayed type hypersensitivity (DTH) in rats.

Ion channels and anti-cancer immunity.

Ion channels and demyelination: basis of a treatment of experimental autoimmune encephalomyelitis (EAE) by potassium channel blockers

K+ channels as targets for specific immunomodulation

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis.

KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis.

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

Potassium channels as therapeutic targets for autoimmune disorders

Potassium channels, memory T cells, and multiple sclerosis

Preparing T cell growth factor from rat splenocytes

Quantitative measurement of GLUT4 translocation to the plasma membrane by flow cytometry.

Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers

Selective blockade of T lymphocyte K+channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis ⬇️

Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease

Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis.

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion ⬇️

The impact of the fourth disulfide bridge in scorpion toxins of the α-KTx6 subfamily

The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain