Lista de obras - Sean T Prigge - Dominio Público Uruguay

A key role for lipoic acid synthesis during Plasmodium liver stage development

artículo científico publicado en 2013

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

artículo científico publicado en 2020

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.

artículo científico publicado en 2017

Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase

artículo científico publicado en 1997

Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae).

artículo científico publicado en 2010

Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum

artículo científico publicado en 2017

Delivery of antimicrobials into parasites

artículo científico publicado en 2003

Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption.

artículo científico publicado en 2021

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase

artículo científico publicado en 2013

Detection of pathogen-specific antibodies by loop-mediated isothermal amplification

artículo científico publicado en 2015

Development of a conditional localization approach to control apicoplast protein trafficking in malaria parasites.

artículo científico publicado en 2019

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

artículo científico publicado en 2013

Differential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase

artículo científico publicado en 2010

Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex

artículo científico publicado en 2004

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

artículo científico publicado en 2013

Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase

artículo científico publicado en 2003

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase

artículo científico publicado en 2006

Fatty Acid synthesis as a target for antimalarial drug discovery.

artículo científico publicado en 2005

Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum

artículo científico publicado en 2002

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

artículo científico publicado en 2010

Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase

artículo científico publicado en 2006

Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

artículo científico publicado en 2010

Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells

artículo científico publicado en 2021

Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.

artículo científico publicado en 2011

Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener.

artículo científico publicado en 2010

Lipoic acid metabolism in microbial pathogens.

artículo científico publicado en 2010

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.

artículo científico publicado en 2005

Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin

artículo científico publicado en 2021

Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

artículo científico publicado en 2020

Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii

artículo científico publicado en 2013

New insights into copper monooxygenases and peptide amidation: structure, mechanism and function

artículo científico publicado en 2000

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway

artículo científico publicado en 2012

Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents

artículo científico publicado en 2013

Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli ⬇️

artículo científico publicado el 11 de octubre de 2010

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases

artículo científico publicado en 2003

Parasites FeS up: iron-sulfur cluster biogenesis in eukaryotic pathogens.

artículo científico publicado en 2013

Plasmodium falciparum apicoplast transit peptides are unstructured in vitro and during apicoplast import.

artículo científico publicado en 2011

Plasmodium falciparumacyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth

artículo científico publicado en 2010

Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

artículo científico publicado en 2005

Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum

artículo científico publicado en 2020

Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum

artículo científico publicado en 2014

Relation between positional specificity and chirality in mammalian lipoxygenases.

artículo científico publicado en 1998

Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum

artículo científico publicado en 2007

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

artículo científico publicado en 2019

Structure and mechanism of lipoxygenases.

artículo científico publicado en 1997

Structure, evolution, and inhibitor interaction of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum

artículo científico publicado en 2003

Studies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

artículo científico publicado en 2007

Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase

artículo científico publicado en 1999

Targeting malaria with specific CDK inhibitors.

artículo científico publicado en 2005

Targeting the Lipid Metabolic Pathways for the Treatment of Malaria

artículo científico publicado en 2010

Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents

artículo científico publicado en 2009

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in plasmodium falciparum

artículo científico publicado en 2020

The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo

artículo científico publicado en 2009

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

artículo científico publicado en 2014

The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role

artículo científico publicado en 2005

The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites

artículo científico publicado en 2013

The tail of mycolic acids.

artículo científico publicado en 2008

Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure

artículo científico publicado en 2007

Lista de obras de Sean T Prigge

A key role for lipoic acid synthesis during Plasmodium liver stage development

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.

Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase

Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae).

Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum

Delivery of antimicrobials into parasites

Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption.

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase

Detection of pathogen-specific antibodies by loop-mediated isothermal amplification

Development of a conditional localization approach to control apicoplast protein trafficking in malaria parasites.

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

Differential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase

Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase

Fatty Acid synthesis as a target for antimalarial drug discovery.

Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase

Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells

Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.

Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener.

Lipoic acid metabolism in microbial pathogens.

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.

Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin

Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii

New insights into copper monooxygenases and peptide amidation: structure, mechanism and function

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway

Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents

Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli ⬇️

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases

Parasites FeS up: iron-sulfur cluster biogenesis in eukaryotic pathogens.

Plasmodium falciparum apicoplast transit peptides are unstructured in vitro and during apicoplast import.

Plasmodium falciparumacyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth

Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum

Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum

Relation between positional specificity and chirality in mammalian lipoxygenases.

Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

Structure and mechanism of lipoxygenases.

Structure, evolution, and inhibitor interaction of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum

Studies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase

Targeting malaria with specific CDK inhibitors.

Targeting the Lipid Metabolic Pathways for the Treatment of Malaria

Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in plasmodium falciparum

The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role

The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites

The tail of mycolic acids.

Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure