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Lista de obras de Edward W Tate

A New Chemical Handle for Protein AMPylation at the Host-Pathogen Interface

artículo científico publicado en 2012

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

scientific article published on 16 April 2020

A highly enantioselective total synthesis of (+)-goniodiol

artículo científico publicado en 2006

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

artículo científico publicado en 2024

A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei

artículo científico publicado en 2012

A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5.

artículo científico publicado en 2014

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Activity-Based Profiling for Drug Discovery

artículo científico publicado en 2011

Activity-Based Protein Profiling for the Study of Parasite Biology

artículo científico publicado en 2019

Activity-based probes: discovering new biology and new drug targets ⬇️

artículo científico publicado el 1 de octubre de 2010

Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes

artículo científico publicado en 2019

Application of activity-based protein profiling to the study of microbial pathogenesis

artículo científico publicado en 2012

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

artículo científico publicado en 2014

Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation.

artículo científico publicado en 2012

BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability

scientific article published on 18 February 2019

Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

scientific article published on 11 December 2019

Bioorthogonal chemical tagging of protein cholesterylation in living cells

artículo científico publicado en 2011

Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.

artículo científico publicado en 2018

CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering

artículo científico publicado en 2020

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells

artículo científico publicado en 2016

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

artículo científico publicado en 2008

Chemical biology tools for probing transcytosis at the blood-brain barrier

artículo científico publicado en 2019

Chemical proteomics: a powerful tool for exploring protein lipidation.

artículo científico

Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid

artículo científico publicado en 2015

Cholesterylation: a tail of hedgehog

artículo científico

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

artículo científico publicado en 2015

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein–protein interaction

scientific article published on 23 July 2010

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

artículo científico publicado en 2017

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.

artículo científico publicado en 2017

Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a

artículo científico publicado en 2019

Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity"

artículo científico publicado en 2020

Correction: Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

artículo científico publicado en 2020

Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors

artículo científico

Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions

artículo científico publicado en 2014

Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction

artículo científico publicado en 2014

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition

artículo científico publicado en 2020

Demographic, Clinical, and Immunologic Features of 389 Children with Opsoclonus-Myoclonus Syndrome: A Cross-sectional Study.

artículo científico publicado en 2017

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

scientific article published on 28 September 2018

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

artículo científico publicado en 2014

Design and Synthesis of Inhibitors of Plasmodium falciparumN -Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

artículo científico publicado en 2012

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling

artículo científico publicado en 2016

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

artículo científico publicado en 2018

Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design

artículo científico publicado en 2016

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferase

artículo científico publicado en 2013

Discovery of Plasmodium vivax N -Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

artículo científico publicado en 2012

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

artículo científico publicado en 2015

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

artículo científico publicado en 2015

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

artículo científico publicado en 2014

Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics

scientific article published on 01 April 2019

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.

artículo científico publicado en 2017

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

artículo científico publicado en 2018

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation

artículo científico publicado en 2014

Getting a chemical handle on proteinpost-translational modification

article

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei ⬇️

artículo científico publicado en 2016

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach

artículo científico publicado en 2015

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani ⬇️

artículo científico publicado en 2015

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells ⬇️

artículo científico publicado en 2014

Global profiling of protein lipidation using chemical proteomic technologies

artículo científico publicado en 2014

High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.

artículo científico publicado en 2018

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation

scientific article published on 28 February 2020

High-yielding F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

scholarly article by Rhiannon Beard et al published 17 July 2018 in Chemical Communications

Highlights from the 46th EUCHEM Conference on stereochemistry, Bürgenstock, Switzerland, May 2011

article

Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins

artículo científico publicado en 2007

Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

scientific article published on 17 July 2019

Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite

artículo científico publicado en 2010

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor

artículo científico publicado en 2015

Membrane bound O-acyltransferases and their inhibitors.

artículo científico publicado en 2015

Membrane enhanced peptide synthesis

scientific article published on 02 March 2010

Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation

Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines

artículo científico publicado en 2015

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

artículo científico publicado en 2007

Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.

artículo científico publicado en 2017

Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry

artículo científico publicado en 2011

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development

artículo científico publicado en 2015

Myristoylation profiling in human cells and zebrafish

artículo científico publicado en 2015

N-Myristoyl transferase-mediated protein labelling in vivo

artículo científico publicado en 2008

N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action

artículo científico publicado en 2018

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells

artículo científico publicado en 2016

N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis

artículo científico

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

artículo científico publicado en 2010

N-myristoyltransferase: a prospective drug target for protozoan parasites

artículo científico publicado en 2008

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

artículo científico publicado en 2014

New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness ⬇️

artículo científico publicado en 2017

Novel inhibitors of surface layer processing in Clostridium difficile

article

Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy.

artículo científico publicado en 2017

Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex

artículo científico publicado en 2020

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

artículo científico publicado en 2014

Pharmacological inhibition of PARP6 triggers multipolar spindle formation and elicits therapeutic effects in breast cancer

artículo científico publicado en 2018

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions

artículo científico publicado en 2018

Photoactive Bifunctional Degraders: Precision Tools To Regulate Protein Stability

artículo científico publicado en 2020

Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces

scientific article published in Journal of Biological Chemistry

Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II.

artículo científico publicado en 2014

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

artículo científico publicado en 2009

Protein myristoylation in health and disease

artículo científico publicado en 2009

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

artículo científico publicado en 2016

Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation

artículo científico publicado en 2015

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

artículo científico publicado en 2020

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs

artículo científico publicado en 2020

Regulation of the Plasmodium Motor Complex: PHOSPHORYLATION OF MYOSIN A TAIL-INTERACTING PROTEIN (MTIP) LOOSENS ITS GRIP ON MyoA

artículo científico publicado en 2012

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs

artículo científico publicado en 2012

Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.

artículo científico publicado en 2007

Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation

artículo científico publicado en 2008

Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes

artículo científico publicado en 2019

Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors

scientific article published on 10 February 2020

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors

scientific article published on 09 May 2019

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors

artículo científico publicado en 2014

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

artículo científico publicado en 2016

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

artículo científico publicado en 2016

Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity.

artículo científico publicado en 2015

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics

artículo científico publicado en 2015

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

artículo científico publicado en 2015

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

artículo científico publicado en 2020

Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex

artículo científico publicado en 2014

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain

artículo científico publicado en 2015

The Rab-binding Profiles of Bacterial Virulence Factors during Infection

artículo científico publicado en 2016

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

artículo científico publicado en 2015

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.

artículo científico publicado en 2017

Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein

artículo científico publicado en 2014

Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II

artículo científico publicado en 2006

Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite

artículo científico publicado en 2013

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes

artículo científico publicado en 2014

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases

scientific article published on 18 April 2019

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach ⬇️

artículo científico publicado en 2014

Whole proteome profiling of -myristoyltransferase activity and inhibition using Sortase-A

artículo científico publicado en 2018

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