Lista de obras - Tohru Natsume - Dominio Público Uruguay

A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells ⬇️

artículo científico publicado el 26 de octubre de 2010

A Novel Nuclear Export Inhibitor JBIR-02, a New Piericidin Discovered from Streptomyces sp. ML55 ⬇️

artículo científico publicado en 2007

A crosslinker-based identification of redox relay targets.

artículo científico publicado en 2016

A large-scale targeted proteomics assay resource based on an in vitro human proteome.

artículo científico publicado en 2016

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

artículo científico publicado en 2004

A novel type of E3 ligase for the Ufm1 conjugation system

artículo científico publicado en 2010

A parallel affinity purification method for selective isolation of polyubiquitinated proteins

scientific article published on 01 August 2008

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis

artículo científico publicado en 2017

Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)

scientific article published on 04 July 2012

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor ⬇️

artículo científico publicado en 2017

An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites

scientific journal article

Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs

artículo científico publicado en 2004

Angiopoietin-like 2, a circadian gene, improves type 2 diabetes through potentiation of insulin sensitivity in mice adipocytes.

artículo científico publicado en 2011

Artificial human Met agonists based on macrocycle scaffolds

artículo científico publicado en 2015

Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration

artículo científico publicado en 2009

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones

artículo científico publicado en 2009

BIA-MS-MS: biomolecular interaction analysis for functional proteomics.

artículo científico publicado en 2001

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

scientific journal article

CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2

artículo científico publicado en 2015

CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.

artículo científico publicado en 2015

CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins

artículo científico publicado en 2015

Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases

artículo científico publicado en 2006

Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.

artículo científico publicado en 2016

Comparative analysis of human SRC-family kinase substrate specificity in vitro.

artículo científico publicado en 2010

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

artículo científico publicado en 2011

Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes

artículo científico publicado en 2006

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells

artículo científico publicado en 2015

Determination of Rate-Limiting Factor for Formation of Beta-Catenin Destruction Complexes Using Absolute Protein Quantification.

artículo científico publicado en 2017

Directed Evolution of a Cyclized Peptoid-Peptide Chimera against a Cell-Free Expressed Protein and Proteomic Profiling of the Interacting Proteins to Create a Protein-Protein Interaction Inhibitor

artículo científico publicado en 2016

Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.

artículo científico publicado en 2016

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

artículo científico publicado en 2011

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway

artículo científico publicado en 2013

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.

artículo científico publicado en 2017

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells

artículo científico publicado en 2017

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

artículo científico publicado en 2013

Functional profiling of asymmetrically-organized human CCT/TRiC chaperonin.

artículo científico publicado en 2016

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

scientific journal article

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

artículo científico publicado en 2011

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

artículo científico publicado en 2007

Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes

artículo científico publicado en 2003

IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling

artículo científico publicado en 2013

IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling

artículo científico publicado en 2013

Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.

artículo científico publicado en 2012

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

artículo científico publicado en 2020

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

artículo científico publicado en 2012

LARP1 specifically recognizes the 3' terminus of poly(A) mRNA

artículo científico publicado en 2013

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor ⬇️

artículo científico publicado el 18 de enero de 2011

Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

artículo científico publicado en 2017

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes

scientific journal article

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase

artículo científico publicado en 2012

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

artículo científico publicado en 2009

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

artículo científico publicado en 2003

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.

artículo científico publicado en 2017

Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.

artículo científico publicado en 2007

Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development

artículo científico publicado en 2009

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)

artículo científico publicado en 2006

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

artículo científico publicado en 2015

Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.

artículo científico publicado en 2009

Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development

scientific journal article

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

artículo científico publicado en 2010

Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format

artículo científico publicado en 2009

Novel thioredoxin-related transmembrane protein TMX4 has reductase activity.

artículo científico publicado en 2010

Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.

artículo científico publicado en 2015

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

scientific journal article

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

artículo científico publicado en 2006

Purification of noncoding RNA and bound proteins using FLAG peptide-conjugated antisense-oligonucleotides.

artículo científico

RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.

artículo científico publicado en 2012

Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress

artículo científico publicado en 2016

SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression

artículo científico publicado en 2012

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals

artículo científico publicado en 2010

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

artículo científico publicado en 2005

Statistical analysis of features associated with protein expression/solubility in an in vivo Escherichia coli expression system and a wheat germ cell-free expression system

scientific article published on 09 April 2011

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.

artículo científico publicado en 2014

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

artículo científico publicado en 2010

TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.

artículo científico publicado en 2016

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress

artículo científico publicado en 2014

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

artículo científico publicado en 2017

Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion

artículo científico publicado en 2017

The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.

artículo científico publicado en 2016

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

artículo científico publicado en 2018

The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport

artículo científico publicado en 2008

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17

artículo científico publicado en 2014

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

artículo científico publicado en 2012

The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.

artículo científico publicado en 2010

The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

artículo científico publicado en 2012

The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression

artículo científico publicado en 2013

The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.

artículo científico publicado en 2015

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

artículo científico publicado en 2010

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

artículo científico publicado en 2015

The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes

artículo científico publicado en 2009

U7 small nuclear ribonucleoprotein represses histone gene transcription in cell cycle-arrested cells.

artículo científico publicado en 2012

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination

artículo científico publicado en 2017

USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression

artículo científico publicado en 2016

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair

artículo científico publicado en 2016

VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels

artículo científico publicado en 2013

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway

scientific journal article

Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility

artículo científico publicado en 2007

XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation

artículo científico

XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway

artículo científico publicado en 2007

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway

scientific journal article

ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.

artículo científico publicado en 2018

Lista de obras de Tohru Natsume

A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells ⬇️

A Novel Nuclear Export Inhibitor JBIR-02, a New Piericidin Discovered from Streptomyces sp. ML55 ⬇️

A crosslinker-based identification of redox relay targets.

A large-scale targeted proteomics assay resource based on an in vitro human proteome.

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

A novel type of E3 ligase for the Ufm1 conjugation system

A parallel affinity purification method for selective isolation of polyubiquitinated proteins

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis

Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor ⬇️

An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites

Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs

Angiopoietin-like 2, a circadian gene, improves type 2 diabetes through potentiation of insulin sensitivity in mice adipocytes.

Artificial human Met agonists based on macrocycle scaffolds

Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones

BIA-MS-MS: biomolecular interaction analysis for functional proteomics.

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2

CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.

CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins

Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases

Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.

Comparative analysis of human SRC-family kinase substrate specificity in vitro.

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells

Determination of Rate-Limiting Factor for Formation of Beta-Catenin Destruction Complexes Using Absolute Protein Quantification.

Directed Evolution of a Cyclized Peptoid-Peptide Chimera against a Cell-Free Expressed Protein and Proteomic Profiling of the Interacting Proteins to Create a Protein-Protein Interaction Inhibitor

Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

Functional profiling of asymmetrically-organized human CCT/TRiC chaperonin.

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes

IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling

IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling

Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

LARP1 specifically recognizes the 3' terminus of poly(A) mRNA

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor ⬇️

Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.

Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.

Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.

Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format

Novel thioredoxin-related transmembrane protein TMX4 has reductase activity.

Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

Purification of noncoding RNA and bound proteins using FLAG peptide-conjugated antisense-oligonucleotides.

RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.

Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress

SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

Statistical analysis of features associated with protein expression/solubility in an in vivo Escherichia coli expression system and a wheat germ cell-free expression system

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion

The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.