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Lista de obras de Daniel Rader

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.

artículo científico publicado en 2017

A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies

artículo científico publicado en 2011

A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency With Severe Triglyceridemia and Pancreatitis.

artículo científico publicado en 2017

A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation.

artículo científico publicado en 2017

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

artículo científico publicado en 2018

A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice ⬇️

artículo científico publicado el 31 de mayo de 2013

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

artículo científico publicado en 2015

A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia

artículo científico publicado en 2007

A genome-first approach to aggregating rare genetic variants in LMNA for association with electronic health record phenotypes

scientific article published on 06 August 2019

A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex

artículo científico publicado en 2012

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease

artículo científico publicado en 2011

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

artículo científico publicado en 2009

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

artículo científico publicado en 2009

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

artículo científico publicado en 2017

A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis

scientific article published on 03 May 2009

A novel ApoA-I truncation (ApoA-IMytilene) associated with decreased ApoA-I production

artículo científico publicado en 2014

A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans.

artículo científico publicado en 2017

A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans

artículo científico publicado en 2016

A phase III randomized trial evaluating alirocumab 300 mg every 4 weeks as monotherapy or add-on to statin: ODYSSEY CHOICE I.

artículo científico publicado en 2016

A pilot trial to examine the effect of high-dose niacin on arterial wall inflammation using fluorodeoxyglucose positron emission tomography.

artículo científico publicado en 2015

A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity

scientific article published on 01 September 2004

A regression framework to uncover pleiotropy in large-scale electronic health record data

scientific article published on 01 October 2019

A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

scientific journal article

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.

artículo científico publicado en 2015

A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction

artículo científico publicado en 2005

AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia

artículo científico publicado en 2014

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

artículo científico publicado en 2017

ATP binding cassette family A protein 1 determines hexosylceramide and sphingomyelin levels in human and mouse plasma

article

ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion

artículo científico publicado en 2017

Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency

artículo científico publicado en 2004

Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis

artículo científico publicado en 2012

Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2.

artículo científico publicado en 2003

Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia

artículo científico publicado en 2012

Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism

artículo científico publicado en 2013

Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation

artículo científico publicado en 2006

Adipose modulation of high-density lipoprotein cholesterol: implications for obesity, high-density lipoprotein metabolism, and cardiovascular disease.

scientific article published on October 2011

An inflammatory cascade leading to hyperresistinemia in humans

artículo científico publicado en 2004

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects

artículo científico publicado en 2015

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects

artículo científico publicado en 2016

Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases

scientific journal article

Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation

artículo científico publicado en 2004

Antisense oligonucleotides for atherosclerotic disease

scientific article published on 06 April 2020

Anti‐oxidative and cholesterol efflux capacities of high‐density lipoprotein are reduced in ischaemic cardiomyopathy ⬇️

artículo científico publicado el 24 de mayo de 2013

Apolipoprotein A-I and cholesterol efflux: the good, the bad, and the modified.

artículo científico publicado en 2014

Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor

artículo científico publicado en 2003

Apolipoprotein E and coronary disease: a puzzling paradox

artículo científico publicado en 2006

Apolipoprotein E suppresses the type I inflammatory response in vivo

artículo científico publicado en 2005

Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222 ⬇️

artículo científico publicado el 19 de diciembre de 2012

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis

artículo científico publicado en 2017

Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins

artículo científico publicado en 2004

Assessment of coronary artery disease by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committe

artículo científico publicado en 2006

Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study

artículo científico publicado en 2015

Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program

artículo científico publicado en 2019

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis

artículo científico publicado en 2020

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

artículo científico publicado en 2015

Association of Inherited Pathogenic Variants in Checkpoint Kinase 2 (CHEK2) With Susceptibility to Testicular Germ Cell Tumors

scientific article published on 01 April 2019

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

artículo científico publicado en 2017

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks

artículo científico publicado en 2014

Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry

artículo científico publicado en 2019

Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification

artículo científico publicado en 2010

Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study

artículo científico publicado en 2019

Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

artículo científico publicado en 2019

Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

scientific article published on 03 September 2019

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100.

artículo científico publicado en 2018

Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches

artículo científico publicado en 2008

Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia

artículo científico publicado en 2013

Biological, clinical and population relevance of 95 loci for blood lipids

artículo científico publicado en 2010

Biomarkers of Calcific Aortic Valve Disease

artículo científico publicado en 2017

Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol

artículo científico publicado en 2009

C-Reactive Protein and Coronary Artery Calcification

artículo científico publicado en 2003

CD44 expressed on both bone marrow-derived and non-bone marrow-derived cells promotes atherogenesis in ApoE-deficient mice

artículo científico publicado en 2008

CD44 regulates vascular gene expression in a proatherogenic environment.

artículo científico publicado en 2007

CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice

artículo científico publicado en 2009

CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects

artículo científico publicado en 2017

COVID-19 outcomes and the human genome

scientific article published on 12 May 2020

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report

artículo científico publicado en 2017

CXCL12: a new player in coronary disease identified through human genetics

artículo científico

CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans

artículo científico publicado en 2007

Candidate gene association resource (CARe): design, methods, and proof of concept

artículo científico publicado en 2010

Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).

artículo científico publicado en 2013

Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening

artículo científico publicado en 2012

Cascade Screening for Familial Hypercholesterolemia and the Use of Genetic Testing.

artículo científico publicado en 2017

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

artículo científico publicado en 2016

Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly

artículo científico publicado en 2016

Characterization of the lipolytic activity of endothelial lipase

artículo científico publicado en 2002

Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.

artículo científico publicado en 2015

Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport

artículo científico publicado en 2012

Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients

artículo científico publicado en 2016

Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis

artículo científico publicado en 2011

Cholesterol efflux capacity: full steam ahead or a bump in the road?

artículo científico publicado en 2013

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

artículo científico publicado en 2015

Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein

scientific article published on 10 March 2016

Cholesteryl ester transfer protein and coronary artery disease: an observation with therapeutic implications

artículo científico publicado en 2004

Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis

artículo científico publicado en 2003

Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease

artículo científico publicado en 2020

Clinical Genetic Testing for Familial Hypercholesterolemia

artículo científico publicado en 2018

Clinical Implications of Lipid Genetics for Cardiovascular Disease

artículo científico publicado en 2010

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

artículo científico publicado en 2016

Combined effects of cholesterol reduction and apolipoprotein A-I expression on atherosclerosis in LDL receptor deficient mice

artículo científico publicado en 2002

Common variants associated with plasma triglycerides and risk for coronary artery disease

artículo científico publicado en 2013

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

artículo científico publicado en 2010

Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer

artículo científico publicado en 2009

Comparative in vivo metabolism of apolipoproteins E2 and E4 in heterozygous apoE2/4 subjects

artículo científico publicado en 2002

Comparison of Coronary Artery Calcium Scores Between Patients With Psoriasis and Type 2 Diabetes

artículo científico publicado en 2016

Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance

artículo científico publicado en 2011

Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.

artículo científico publicado en 2005

Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8.

artículo científico publicado en 2006

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

artículo científico publicado en 2008

Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach

artículo científico publicado en 2004

Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factors

artículo científico publicado en 2002

Correcting population stratification in genetic association studies using a phylogenetic approach

artículo científico publicado en 2010

Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease

artículo científico publicado en 2020

Could exercise metabolomics pave the way for gymnomimetics?

artículo científico publicado en 2010

Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer.

artículo científico publicado en 2005

Decreased Expression of ARV1 Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism* ⬇️

artículo científico publicado el 27 de julio de 2010

Deep Apolipoprotein Proteomics to Uncover Mechanisms of Coronary Disease Risk

artículo científico publicado en 2017

Deep RNA Sequencing Uncovers a Repertoire of Human Macrophage Long Intergenic Noncoding RNAs Modulated by Macrophage Activation and Associated With Cardiometabolic Diseases

artículo científico publicado en 2017

Demystifying triglycerides: a practical approach for the clinician.

artículo científico publicado en 2005

Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol

artículo científico publicado en 2011

Design and synthesis of boronic acid inhibitors of endothelial lipase ⬇️

artículo científico publicado el 13 de diciembre de 2011

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls

artículo científico publicado en 2010

Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339.

artículo científico publicado en 2005

Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia

artículo científico publicado en 2016

Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha

artículo científico publicado en 2005

Differential association of plasma angiopoietin-like proteins 3 and 4 with lipid and metabolic traits

artículo científico publicado en 2014

Differential network enrichment analysis reveals novel lipid pathways in chronic kidney disease

scientific article published on 01 September 2019

Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium ⬇️

artículo científico publicado en 2018

Discovery and refinement of loci associated with lipid levels

artículo científico publicado en 2013

Discovery and validation of new molecular targets in treating dyslipidemia: the role of human genetics

artículo científico publicado en 2009

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

artículo científico publicado en 2020

Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics

artículo científico publicado en 2016

Dose-Dependent Acceleration of High-Density Lipoprotein Catabolism by Endothelial Lipase ⬇️

artículo científico publicado el 29 de septiembre de 2003

Drugs in development: targeting high-density lipoprotein metabolism and reverse cholesterol transport

artículo científico publicado en 2005

Dyslipidaemia: cardiovascular prevention--end of the road for niacin?

artículo científico publicado en 2014

Dyslipidemia in insulin resistance: clinical challenges and adipocentric therapeutic frontiers

artículo científico publicado en 2008

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial

artículo científico publicado en 2018

Effect of Access to Prescribed PCSK9 Inhibitors on Cardiovascular Outcomes

artículo científico publicado en 2019

Effect of interleukin 1β inhibition in cardiovascular disease ⬇️

artículo científico publicado el 1 de diciembre de 2012

Effect of rosiglitazone on HDL metabolism in subjects with metabolic syndrome and low HDL ⬇️

artículo científico publicado el 22 de octubre de 2010

Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism

artículo científico publicado en 2012

Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E

artículo científico publicado en 2017

Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program

artículo científico publicado en 2018

Effects of Niacin, Statin, and Fenofibrate on Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels in Patients With Dyslipidemia

artículo científico publicado en 2014

Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol

artículo científico publicado en 2004

Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism

artículo científico publicado en 2009

Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion.

artículo científico publicado en 2005

Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice

scientific article published on 27 September 2008

Effects of nonlipolytic ligand function of endothelial lipase on high density lipoprotein metabolism in vivo

artículo científico publicado en 2003

Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome

artículo científico publicado en 2005

Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome

artículo científico publicado en 2005

Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism.

artículo científico publicado en 2007

Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans

artículo científico publicado en 2006

Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses

artículo científico publicado en 2016

Efficacy and Safety of Alirocumab 300 mg Every 4 Weeks in Individuals With Type 2 Diabetes on Maximally Tolerated Statin

scientific article published on 01 November 2019

Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher

artículo científico publicado en 2016

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study ⬇️

artículo científico publicado el 2 de noviembre de 2012

Efficacy and safety of lipid lowering by alirocumab in chronic kidney disease.

artículo científico publicado en 2018

Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries

artículo científico publicado en 2008

Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport

artículo científico publicado en 2006

Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway

artículo científico publicado en 2003

Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase

artículo científico publicado en 2003

Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis

artículo científico publicado en 2005

Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.

artículo científico publicado en 2013

Endothelial lipase is increased in vivo by inflammation in humans

artículo científico publicado en 2008

Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II

scientific article published on 30 July 2006

Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins

artículo científico publicado en 2004

Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation

artículo científico publicado en 2004

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

artículo científico publicado en 2017

Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort

artículo científico publicado en 2016

Evidence That Hepatic Lipase and Endothelial Lipase Have Different Substrate Specificities for High-Density Lipoprotein Phospholipids ⬇️

artículo científico publicado el 25 de noviembre de 2003

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia

artículo científico publicado en 2013

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

artículo científico publicado en 2014

Exome sequencing in suspected monogenic dyslipidemias

artículo científico publicado en 2015

Exome-wide association study of plasma lipids in >300,000 individuals

artículo científico publicado en 2017

Experimental Therapeutics for Challenging Clinical Care of a Patient with an Extremely Rare Homozygous APOC2 Mutation

artículo científico publicado en 2020

Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport

scientific article published on 20 August 2007

Expression of human hepatic lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native high-density lipoprotein apolipoprotein A-I.

artículo científico publicado en 2003

Extended-release niacin acutely suppresses postprandial triglyceridemia

artículo científico publicado en 2012

FBN1 Coding Variants and Nonsyndromic Aortic Disease

scientific article published on 18 June 2019

Familial Chylomicronemia Syndrome With a Novel Homozygous LPL Mutation Identified in Three Siblings in Their 50s

scientific article published on 19 November 2019

Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

artículo científico publicado en 2011

Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia.

artículo científico publicado en 2011

Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia

artículo científico publicado en 2011

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

artículo científico publicado en 2017

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport

artículo científico publicado en 2017

Fish oil promotes macrophage reverse cholesterol transport in mice

artículo científico publicado en 2009

Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial.

artículo científico publicado en 2008

Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models

artículo científico publicado en 2007

Fluorescent green plaques: light at the end of the catheter? ⬇️

artículo científico publicado en 2011

From Darwin's finches to canaries in the coal mine--mining the genome for new biology

artículo científico publicado en 2008

From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease

artículo científico publicado en 2016

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

artículo científico publicado en 2010

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease

artículo científico publicado en 2015

Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes

artículo científico publicado en 2011

Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis ⬇️

artículo científico publicado el 19 de octubre de 2010

Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies

artículo científico publicado en 2010

Gene therapy for lipoprotein disorders

artículo científico publicado en 2005

Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent

artículo científico publicado en 2007

Gene-based interaction analysis by incorporating external linkage disequilibrium information

artículo científico publicado en 2010

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

artículo científico publicado en 2014

Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations

artículo científico publicado en 2012

Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells

artículo científico publicado en 2015

Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program

scientific article published on 28 September 2020

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

artículo científico publicado en 2016

Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin

artículo científico publicado en 2018

Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.

artículo científico publicado en 2012

Genetic analysis for a shared biological basis between migraine and coronary artery disease

artículo científico publicado en 2015

Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver

scientific article published on 13 June 2019

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

artículo científico publicado en 2017

Genetic basis of atherosclerosis: insights from mice and humans

artículo científico publicado en 2012

Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy

artículo científico publicado en 2017

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

artículo científico publicado en 2018

Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis.

scientific article published on 10 January 2014

Genetic regulation of nonsense-mediated decay underlies association with risk of severe COVID-19

artículo científico publicado en 2021

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

artículo científico publicado en 2010

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease

artículo científico publicado en 2017

Genetically Determined Birthweight Associates with Atrial Fibrillation: A Mendelian Randomization Study

scientific article published on 27 April 2020

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

artículo científico publicado en 2018

Genetics of height and risk of atrial fibrillation: A Mendelian randomization study

artículo científico publicado en 2020

Genetics of increased HDL cholesterol levels: insights into the relationship between HDL metabolism and atherosclerosis

artículo científico publicado en 2003

Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease

artículo científico publicado en 2014

Genome-wide approaches to finding novel genes for lipid traits: the start of a long road

scientific article published on 01 October 2008

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

scientific article published on 01 November 2019

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

artículo científico publicado en 2009

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India

artículo científico publicado en 2013

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

scientific journal article

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

artículo científico publicado en 2019

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project

artículo científico publicado en 2011

Genome-wide association study of peripheral artery disease in the Million Veteran Program

scientific article published on 08 July 2019

Genomic Risk Stratification Predicts All-Cause Mortality After Cardiac Catheterization

scientific article published on 01 November 2018

Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

scientific article published on 06 May 2020

Genomic medicine in the prevention and treatment of atherosclerotic cardiovascular disease

artículo científico publicado en 2012

Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases

scientific article published on 09 January 2020

Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants

scientific article published on 20 June 2019

GlycA Is a Novel Biomarker of Inflammation and Subclinical Cardiovascular Disease in Psoriasis.

artículo científico publicado en 2016

Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo

artículo científico publicado en 2007

Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial

artículo científico publicado en 2003

HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study

scientific article published on 03 December 2020

HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics

artículo científico publicado en 2017

HDL and cardiovascular disease

artículo científico publicado en 2014

HDL re-examined

artículo científico publicado en 2015

Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry

artículo científico publicado en 2017

Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo

artículo científico publicado en 2005

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity.

artículo científico publicado en 2017

Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis.

artículo científico publicado en 2017

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

artículo científico publicado en 2012

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

scientific article published on 30 August 2020

High density lipoprotein cholesterol and cancer: Marker or causative?

artículo científico publicado en 2018

High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease

artículo científico publicado en 2015

High-density lipoprotein cholesterol therapies: the next frontier in lipid management

artículo científico publicado en 2006

High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion.

artículo científico publicado en 2006

High-density lipoprotein particle number: a better measure to quantify high-density lipoprotein?

artículo científico publicado en 2012

High-density lipoprotein: NO failure in heart failure.

artículo científico publicado en 2013

High-density lipoproteins: a consensus statement from the National Lipid Association

artículo científico publicado en 2013

Higher order lipase gene association with plasma triglycerides

article

Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study

artículo científico publicado en 2013

Human genetics of variation in high-density lipoprotein cholesterol

artículo científico publicado en 2006

Human genetics shines a light on ischaemic stroke

scientific article published on 19 December 2015

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

artículo científico publicado en 2017

Human knockouts in a cohort with a high rate of consanguinity

Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice

artículo científico publicado en 2002

ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice

scientific article published on 11 September 2020

Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques

artículo científico publicado en 2011

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

artículo científico publicado en 2011

Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol

artículo científico publicado en 2002

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

artículo científico publicado en 2017

Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation

artículo científico publicado en 2009

Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection

artículo científico publicado en 2022

Impaired cholesterol efflux capacity and vasculoprotective function of high-density lipoprotein in heart transplant recipients

artículo científico publicado en 2014

Implementing Genomic Medicine in the Clinic

Implementing genomic medicine in the clinic: the future is here

artículo científico publicado en 2013

In Memoriam: Julian B. Marsh (1926–2018)

scientific article published in 2019

In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux ⬇️

artículo científico publicado el 1 de noviembre de 2003

Inactivating mutations in NPC1L1 and protection from coronary heart disease

artículo científico publicado en 2014

Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation

artículo científico publicado en 2005

Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice

artículo científico publicado en 2007

Inflammation induces fibrinogen nitration in experimental human endotoxemia

artículo científico publicado en 2009

Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice

artículo científico publicado en 2010

Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo

artículo científico publicado en 2003

Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia

artículo científico publicado en 2008

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

artículo científico publicado en 2007

Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels

artículo científico publicado en 2004

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

artículo científico publicado en 2012

Interrogation of the Atherosclerosis-Associated SORT1 (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice

artículo científico publicado en 2017

Is the cholesteryl ester transfer protein proatherogenic or antiatherogenic in humans?

scientific article published on 29 October 2007

JCL roundtable: drug treatment of severe forms of familial hypercholesterolemia

artículo científico publicado en 2013

Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice

scientific journal article

Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice

artículo científico publicado en 2015

Laboratory assessment of HDL heterogeneity and function

artículo científico publicado en 2008

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.

artículo científico publicado en 2017

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies

artículo científico publicado en 2010

Lack of pathogenic germline DICER1 variants in males with testicular germ-cell tumors

artículo científico publicado en 2020

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci

artículo científico publicado en 2017

Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity

artículo científico publicado en 2017

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

artículo científico publicado en 2017

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

artículo científico publicado en 2011

Large-scale association analysis identifies new risk loci for coronary artery disease

artículo científico publicado en 2012

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

artículo científico publicado en 2012

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

artículo científico publicado en 2012

Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo

artículo científico publicado en 2009

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease

scientific article published on 01 June 2020

Lipase H, a new member of the triglyceride lipase family synthesized by the intestine

artículo científico publicado en 2002

Lipases and HDL metabolism

artículo científico publicado en 2002

Lipases as modulators of atherosclerosis in murine models

artículo científico publicado en 2007

Lipid and apolipoprotein ratios: association with coronary artery disease and effects of rosuvastatin compared with atorvastatin, pravastatin, and simvastatin

artículo científico publicado en 2003

Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism

artículo científico publicado en 2021

Lipid-lowering treatment for homozygous familial hypercholesterolaemia – Authors' reply ⬇️

artículo científico publicado el 6 de abril de 2013

Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.

artículo científico publicado en 2014

Lipids, Apolipoproteins, and Risk of Atherosclerotic Cardiovascular Disease in Persons With CKD

artículo científico publicado en 2019

Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a].

artículo científico publicado en 2005

Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).

artículo científico

Lipoproteins as biomarkers and therapeutic targets in the setting of acute coronary syndrome

artículo científico publicado en 2014

Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell?

artículo científico publicado en 2005

Loci influencing blood pressure identified using a cardiovascular gene-centric array

artículo científico publicado en 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

artículo científico publicado en 2013

Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia

artículo científico publicado en 2014

Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia

artículo científico publicado en 2017

Long-term effects of LDL apheresis in patients with severe hypercholesterolemia

artículo científico publicado en 2005

Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia

artículo científico publicado en 2008

Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry

scientific article published on 19 August 2019

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

artículo científico publicado en 2017

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

artículo científico publicado en 2016

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans

artículo científico publicado en 2009

Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo

scientific journal article

Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano

artículo científico publicado en 2009

Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?

artículo científico publicado en 2006

Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis

artículo científico publicado en 2015

Managing diabetic dyslipidemia: beyond statin therapy

artículo científico publicado en 2009

Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry ⬇️

artículo científico publicado el 16 de enero de 2012

Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry ⬇️

artículo científico publicado el 30 de junio de 2013

Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines

article

Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis

artículo científico publicado en 2004

Measuring niacin-associated skin toxicity (NASTy) stigmata along with symptoms to aid development of niacin mimetics

artículo científico publicado en 2017

Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease

scientific article published on 27 August 2020

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

artículo científico publicado en 2010

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

artículo científico publicado en 2010

Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study

artículo científico publicado en 2011

Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide

artículo científico publicado en 2015

Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.

artículo científico publicado en 2008

Microsomal transfer protein inhibition in humans ⬇️

artículo científico publicado el 1 de junio de 2013

Mighty Minipig in Fight Against Cardiovascular Disease ⬇️

artículo científico publicado el 2 de enero de 2013

Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol

artículo científico publicado en 2011

Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators

artículo científico publicado en 2017

Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes

artículo científico publicado en 2010

Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.

artículo científico publicado en 2013

Monogenic hypercholesterolemia: new insights in pathogenesis and treatment

artículo científico publicado en 2003

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project

artículo científico publicado en 2012

Multi-ethnic genome-wide association study for atrial fibrillation

article

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.

artículo científico publicado en 2016

Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans

artículo científico publicado en 2018

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

artículo científico publicado en 2019

N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins

artículo científico publicado en 2007

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

artículo científico publicado en 2004

NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis

artículo científico publicado en 2018

Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy

artículo científico publicado en 2016

New targets and emerging therapies for reducing LDL cholesterol

artículo científico publicado en 2007

Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR+/- Rhesus Macaques.

artículo científico publicado en 2017

Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia

artículo científico publicado en 2017

Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council

artículo científico publicado en 2015

Normal production rate of apolipoprotein B in LDL receptor-deficient mice

artículo científico publicado en 2002

Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein

artículo científico publicado en 2009

Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function

scientific article published on 15 April 2020

Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages.

artículo científico publicado en 2011

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Nuclear Receptors and microRNA-144 Coordinately Regulate Cholesterol Efflux ⬇️

artículo científico publicado el 7 de junio de 2013

On-Statin Cholesteryl Ester Transfer Protein Mass and Risk of Recurrent Coronary Events (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 [PROVE IT-TIMI 22] Study) ⬇️

artículo científico publicado el 15 de agosto de 2010

On-Statin Resistin, Leptin, and Risk of Recurrent Coronary Events After Hospitalization for an Acute Coronary Syndrome (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Study).

artículo científico publicado en 2015

Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial

artículo científico publicado en 2017

Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

artículo científico publicado en 2017

Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo

artículo científico publicado en 2003

Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo.

artículo científico publicado en 2008

Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice

artículo científico publicado en 2011

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort

artículo científico publicado en 2020

PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI.

artículo científico publicado en 2011

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

artículo científico publicado en 2021

Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.

artículo científico publicado en 2011

Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages

artículo científico publicado en 2009

Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production

artículo científico publicado en 2015

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing

artículo científico publicado en 2014

Peroxisome Proliferator-Activated Receptor-α Activation Promotes Macrophage Reverse Cholesterol Transport Through a Liver X Receptor–Dependent Pathway ⬇️

artículo científico publicado el 24 de marzo de 2011

Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1.

artículo científico publicado en 2005

Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport

artículo científico publicado en 2011

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

artículo científico publicado en 2005

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways

scientific article published on 17 February 2020

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

artículo científico publicado en 2016

Phenotypic extremes in rare variant study designs

artículo científico publicado en 2015

Phospholipidation of HDL--how much is too much?

artículo científico publicado en 2010

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

artículo científico publicado en 2012

Plasma Leptin Levels Are Associated with Coronary Atherosclerosis in Type 2 Diabetes

scientific article published on 01 August 2004

Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics

artículo científico publicado en 2015

Plasma cytokines, metabolic syndrome, and atherosclerosis in humans

artículo científico publicado en 2007

Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting

artículo científico

Polygenic Risk Scores and Coronary Artery Disease: Ready for Prime Time?

artículo científico publicado en 2020

Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals

scientific article published on 06 July 2020

Polygenic determinants in extremes of high-density lipoprotein cholesterol

artículo científico publicado en 2017

Polyphenols and cholesterol efflux: is coffee the next red wine?

artículo científico publicado en 2010

Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes.

artículo científico publicado en 2002

Potent and selective PPAR-alpha agonist LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome

artículo científico publicado en 2008

Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome

artículo científico publicado en 2015

Practical immunoaffinity-enrichment LC-MS for measuring protein kinetics of low-abundance proteins

artículo científico publicado en 2014

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

artículo científico publicado en 2010

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase

scientific journal article

Prospective CYP2C19 Genotyping to Guide Antiplatelet Therapy Following Percutaneous Coronary Intervention: A Pragmatic Randomized Clinical Trial

scientific article published on 12 January 2020

Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease.

artículo científico publicado en 2011

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

artículo científico publicado en 2017

Quantification of abdominal fat from computed tomography using deep learning and its association with electronic health records in an academic biobank

artículo científico publicado en 2021

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article

Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry

artículo científico publicado en 2013

Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component

artículo científico publicado en 2015

Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial

artículo científico publicado en 2009

Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure

scientific article published on 02 April 2020

Reduced efficacy of rosuvastatin by St. John's Wort

artículo científico publicado en 2009

Reducing the burden of disease and death from familial hypercholesterolemia: a call to action

artículo científico publicado en 2014

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

article

Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study

artículo científico publicado en 2011

Residual macrovascular risk in 2013: what have we learned?

artículo científico publicado en 2014

Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians

artículo científico publicado en 2008

Resistin is an inflammatory marker of atherosclerosis in humans.

artículo científico publicado en 2005

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

artículo científico publicado en 2015

Role of N-linked glycosylation in the secretion and activity of endothelial lipase

artículo científico publicado en 2004

SARS-CoV-2 Seroprevalence Among Parturient Women

scientific article published on 10 July 2020

SARS-CoV-2 seroprevalence among parturient women in Philadelphia

artículo científico publicado en 2020

SLCO1B1 and Statin Therapy

artículo científico publicado en 2018

Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study

artículo científico publicado en 2016

Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients

artículo científico publicado en 2008

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

scientific article published on 10 November 2020

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study

scientific article published on 31 July 2013

Self-Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene

scientific article published on 08 July 2020

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

artículo científico publicado en 2009

Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

artículo científico publicado en 2015

Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production

artículo científico publicado en 2006

Short-term treatment with high-dose atorvastatin reduces LDL cholesterol but shows no anti-inflammatory effects in normolipidemic subjects with normal CRP levels

artículo científico publicado en 2010

Soluble FMS-Like Tyrosine Kinase-1 Is a Circulating Biomarker Associated With Calcific Aortic Stenosis

scientific article published on 01 March 2019

Sortilin and lipoprotein metabolism: making sense out of complexity

artículo científico publicado en 2014

Sortilin as a Regulator of Lipoprotein Metabolism ⬇️

artículo científico publicado el 1 de junio de 2012

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

artículo científico publicado en 2016

Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol

artículo científico publicado en 2016

Statins and cognitive function: a systematic review

artículo científico publicado en 2013

Strong synaptic transmission impact by copy number variations in schizophrenia

artículo científico publicado en 2010

Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I.

artículo científico publicado en 2009

Structural basis of endothelial lipase tropism for HDL.

artículo científico publicado en 2004

Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells

artículo científico publicado en 2007

Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras

artículo científico publicado en 2006

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

artículo científico publicado en 2017

Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction

artículo científico publicado en 2015

Systematically Sifting Big Data to Identify Novel Causal Genes for Human Traits

artículo científico publicado en 2020

TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.

artículo científico publicado en 2016

Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution

artículo científico publicado en 2016

Targeting ApoC-III to Reduce Coronary Disease Risk

artículo científico publicado en 2016

Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition

artículo científico publicado en 2021

Text mining applied to electronic cardiovascular procedure reports to identify patients with trileaflet aortic stenosis and coronary artery disease

artículo científico publicado en 2017

The Role of Emerging Biomarkers in Unraveling the Complex Biology Underlying Associations between HDL Cholesterol and Cardiovascular Diseases

artículo científico publicado en 2016

The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

artículo científico publicado en 2009

The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages

artículo científico publicado en 2010

The addition of niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality

artículo científico publicado en 2013

The complexity of ABO in coronary heart disease – Authors' reply

artículo científico publicado en 2011

The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans

artículo científico publicado en 2009

The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice

scientific journal article

The effects of statin therapy on plasma markers of inflammation in patients without vascular disease.

artículo científico publicado en 2005

The evolution and refinement of traditional risk factors for cardiovascular disease

artículo científico publicado en 2012

The frequency of the cholesteryl ester transfer protein-TaqI B2 allele is lower in African Americans than in Caucasians

artículo científico publicado en 2002

The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans

artículo científico publicado en 2008

The metabolic syndrome: more than the sum of its parts?

artículo científico publicado en 2003

The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis?

artículo científico publicado en 2012

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels

artículo científico publicado en 2011

The role of endothelial lipase in high-density lipoprotein metabolism

artículo científico publicado en 2004

The role of high density lipoproteins in thrombosis.

artículo científico publicado en 2002

The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes

scientific article published on 13 February 2020

The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis

artículo científico publicado en 2008

The roles of different pathways in the release of cholesterol from macrophages

artículo científico publicado en 2007

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

article

The triglyceride-high-density lipoprotein axis: an important target of therapy?

artículo científico publicado en 2004

Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics

artículo científico publicado en 2016

Tissue-specific expression pattern of human endothelial lipase in transgenic mice

scientific article published on 24 February 2005

Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo

artículo científico publicado en 2010

Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance.

artículo científico publicado en 2009

Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing

artículo científico publicado en 2016

Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis

artículo científico publicado en 2012

Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry

artículo científico publicado en 2016

Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function.

artículo científico publicado en 2010

Trials and Tribulations of CETP Inhibitors

artículo científico publicado en 2017

Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice

artículo científico publicado en 2010

Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα

artículo científico publicado en 2015

Triglyceride-rich lipoproteins and coronary artery disease risk: new insights from human genetics

artículo científico publicado en 2015

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

article

US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry

artículo científico publicado en 2016

Underdiagnosis and undertreatment of cardiovascular risk factors in patients with moderate to severe psoriasis.

artículo científico publicado en 2011

Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis ⬇️

artículo científico publicado el 15 de octubre de 2010

Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production

artículo científico publicado en 2007

Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus

artículo científico publicado en 2011

VLDL Hydrolysis by Hepatic Lipase Regulates PPARδ Transcriptional Responses ⬇️

artículo científico publicado el 5 de julio de 2011

Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification

artículo científico publicado en 2002

Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program

artículo científico publicado en 2020

Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease

artículo científico publicado en 2016

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

artículo científico publicado en 2006

Vasomotor symptoms and lipids/lipoprotein subclass metrics in midlife women: Does level of endogenous estradiol matter? The SWAN HDL Ancillary Study

artículo científico publicado en 2020

Web of Science’s Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor

artículo científico publicado en 2022

When HDL gets fat...

artículo científico publicado en 2008

Whole-genome sequencing reveals host factors underlying critical COVID-19

artículo científico publicado en 2022

Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux

scientific article published on 05 July 2007

Zinc transporter Slc39a8 is essential for cardiac ventricular compaction

artículo científico publicado en 2018

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