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Lista de obras de Guy A. Rutter

35th Annual Meeting of the European Association for the Study of Diabetes

artículo científico

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics

artículo científico publicado en 2003

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors that Control GLP-1 Receptor Signaling in Pancreatic Beta Cells.

artículo científico publicado en 2017

A phogrin–aequorin chimaera to image free Ca2+ in the vicinity of secretory granules ⬇️

artículo científico publicado el 15 de marzo de 1998

A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-κB pathway and IL-1β-induced islet inflammation and increases insulin secretion

scientific article published on 30 June 2020

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults

artículo científico publicado en 2008

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function.

artículo científico publicado en 2015

A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation.

artículo científico publicado en 2009

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

artículo científico publicado en 2020

ADCY5 couples glucose to insulin secretion in human islets

artículo científico publicado en 2014

AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?

artículo científico publicado en 2002

AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions

artículo científico publicado en 2004

ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile

artículo científico publicado en 2007

ATP regulation in adult rat cardiomyocytes: time-resolved decoding of rapid mitochondrial calcium spiking imaged with targeted photoproteins

artículo científico publicado en 2006

ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer

artículo científico publicado en 2003

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice

artículo científico publicado en 2020

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization from Acidic Stores in Pancreatic α-Cells

artículo científico publicado en 2018

Age matters: Grading granule secretion in beta cells

artículo científico publicado en 2020

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish.

artículo científico publicado en 2018

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

scientific article published on 20 August 2019

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.

artículo científico publicado en 2016

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes ⬇️

artículo científico publicado el 14 de septiembre de 2011

An essential role for the Zn2+ transporter ZIP7 in B cell development

artículo científico publicado en 2019

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene.

artículo científico publicado en 2017

Animal models of GWAS-identified type 2 diabetes genes

artículo científico publicado en 2013

Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

artículo científico publicado en 2018

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

artículo científico publicado en 2016

Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

artículo científico publicado en 2014

Biologically targeted probes for Zn(2+): a diversity oriented modular "click-SNAr-click" approach†Electronic supplementary information (ESI) available: Full experimental details including characterisation of all novel compounds can be found in the E

artículo científico publicado en 2014

Ca2+ microdomains and the control of insulin secretion

artículo científico publicado en 2006

Ca2+ signalling: a new route to NAADP.

artículo científico publicado en 2008

Ca2+-induced Ca2+ release in pancreatic islet beta-cells: critical evaluation of the use of endoplasmic reticulum-targeted "cameleons".

artículo científico publicado en 2004

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.

artículo científico publicado en 2014

Calcium signalling: NAADP comes out of the shadows

artículo científico publicado en 2003

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression

artículo científico publicado en 2016

Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells

artículo científico publicado en 2009

Cell biology. Pancreas micromanages autophagy.

artículo científico publicado en 2015

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

artículo científico publicado en 2016

Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.

scientific article published on February 2010

ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells

artículo científico publicado en 2006

ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells

artículo científico publicado en 2010

Changes in microRNA expression during differentiation of embryonic and induced pluripotent stem cells to definitive endoderm.

artículo científico publicado en 2015

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice

artículo científico publicado en 2016

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

artículo científico publicado en 2016

Chronic d-serine supplementation impairs insulin secretion

artículo científico publicado en 2018

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

scientific journal article

Comment on Satin et al. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830-836

artículo científico publicado en 2020

Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975 ⬇️

artículo científico publicado el 1 de octubre de 2012

Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells

scientific article published on 01 September 2020

Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

artículo científico publicado en 2009

Control of insulin secretion by GLP-1.

artículo científico publicado en 2018

Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish

artículo científico publicado en 2019

Correction: Transcription factor-7-like 2 () gene acts downstream of the kinase to control mTOR signaling, β cell growth, and insulin secretion

artículo científico publicado en 2018

Corrigendum: Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats

artículo científico publicado en 2016

Could lncRNAs contribute to β-cell identity and its loss in Type 2 diabetes? ⬇️

artículo científico publicado el 1 de junio de 2013

Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism ⬇️

artículo científico publicado el 10 de agosto de 1998

Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1.

artículo científico publicado en 2004

DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs.

artículo científico publicado en 2015

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

artículo científico publicado en 2017

Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1

artículo científico publicado en 2015

Diabetes: Controlling the identity of the adult pancreatic β cell

artículo científico publicado en 2017

Dietary substitution of saturated with monounsaturated fatty acids within high-fat diets attenuates hyperinsulinemia and pancreatic islet dysfunction

artículo científico publicado en 2020

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

artículo científico publicado en 2016

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

scientific article published on 08 April 2020

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

artículo científico publicado en 2021

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

artículo científico publicado en 2004

Divergent effects of liraglutide, exendin-4, and sitagliptin on beta-cell mass and indicators of pancreatitis in a mouse model of hyperglycaemia

artículo científico publicado en 2014

Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes

artículo científico publicado en 2014

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity

artículo científico publicado en 2018

Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging.

artículo científico publicado en 2015

Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells

artículo científico publicado en 2010

Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 Cells using recombinant targeted cameleons: roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors

artículo científico publicado en 2002

Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels

artículo científico publicado en 2002

Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells

artículo científico publicado en 2002

Effects of insulin and guanosine 5'-[gamma-thio]triphosphate on fatty acid synthesis and lipolysis within electropermeabilized fat-cells ⬇️

artículo científico publicado el 15 de enero de 1992

Effects of protein phosphatase inhibitors on the regulation of insulin-sensitive enzymes within rat epididymal fat-pads and cells ⬇️

artículo científico publicado el 15 de junio de 1991

Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide

scientific article published on 18 November 2019

Expanding role of AMPK in endocrinology.

artículo científico publicado en 2006

Fostering improved human islet research: a European perspective

scientific article published on 13 June 2019

FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells

artículo científico publicado en 2006

Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells

artículo científico publicado en 2012

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research

artículo científico publicado en 2020

GABA signaling: A route to new pancreatic β cells.

artículo científico publicado en 2017

Generating new candidate genes for neonatal diabetes: functional and genetic studies of insulin secretion in type 2 diabetes

artículo científico publicado en 2007

Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signalling at glucagon family receptors

scientific article published on 01 December 2020

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

artículo científico publicado en 2009

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

artículo científico publicado en 2003

Glucocorticoid Metabolism in Obesity and Following Weight Loss

artículo científico publicado en 2020

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion

artículo científico publicado en 2017

Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release

scientific article published on 31 March 2020

Glucose is necessary for embryonic pancreatic endocrine cell differentiation.

artículo científico publicado en 2007

Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells.

artículo científico publicado en 2003

Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.

artículo científico publicado en 2005

Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells

artículo científico publicado en 2011

Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?

artículo científico publicado en 2006

Glucose-dependent Translocation of Insulin Promoter Factor-1 (IPF-1) between the Nuclear Periphery and the Nucleoplasm of Single MIN6 β-Cells ⬇️

artículo científico publicado el 4 de septiembre de 1998

Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells.

artículo científico publicado en 2007

Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells

scientific journal article

Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets

artículo científico publicado en 2002

Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet beta-cells: evidence for a Ca2+-dependent mechanism

artículo científico publicado en 2002

Green fluorescent protein calcium biosensors. Calcium imaging with GFP cameleons

artículo científico publicado en 2002

Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse

artículo científico publicado en 2022

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

artículo científico publicado en 2011

Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.

artículo científico publicado en 2017

Hypothalamic AMP-activated protein kinase regulates glucose production

artículo científico publicado en 2010

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis

artículo científico publicado en 2018

Hypothalamic glucagon signals through the KATP channels to regulate glucose production

artículo científico publicado en 2013

Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo

artículo científico publicado en 2010

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

artículo científico publicado en 2014

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

artículo científico publicado en 2004

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

artículo científico publicado en 2023

Identification of genes selectively disallowed in the pancreatic islet.

artículo científico publicado en 2010

Imaging a target of Ca2+ signalling: dense core granule exocytosis viewed by total internal reflection fluorescence microscopy

artículo científico publicado en 2008

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR).

artículo científico publicado en 2011

Imaging glucose-regulated insulin secretion and gene expression in single islet beta-cells: control by AMP-activated protein kinase

artículo científico publicado en 2004

Impact of PPARgamma overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays

artículo científico publicado en 2004

Impact of adenoviral transduction with SREBP1c or AMPK on pancreatic islet gene expression profile: analysis with oligonucleotide microarrays

artículo científico publicado en 2004

Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM

artículo científico publicado en 2004

Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6).

artículo científico publicado en 2004

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion

artículo científico publicado en 2013

Incretin-modulated beta cell energetics in intact islets of Langerhans

artículo científico publicado en 2014

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

artículo científico publicado en 2007

Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.

artículo científico publicado en 2004

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

artículo científico publicado en 2008

Insulin Secretion: Fatty Acid Signalling via Serpentine Receptors ⬇️

artículo científico publicado el 13 de mayo de 2003

Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

artículo científico publicado en 2009

Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors

artículo científico publicado en 2006

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

artículo científico publicado en 2009

Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase ⬇️

artículo científico publicado el 15 de abril de 1998

Insulin vesicle release: walk, kiss, pause ... then run.

artículo científico publicado en 2006

Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes

scientific article published on 01 March 2002

Integrating cytosolic calcium signals into mitochondrial metabolic responses ⬇️

artículo científico publicado el 1 de septiembre de 1998

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

artículo científico publicado en 2015

Involvement of MAP kinase in insulin signalling revealed by non-invasive imaging of luciferase gene expression in single living cells ⬇️

artículo científico publicado el 1 de agosto de 1995

Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose

artículo científico publicado en 2004

Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic beta-cells.

artículo científico publicado en 2002

Isolation and culture of mouse pancreatic islets for ex vivo imaging studies with trappable or recombinant fluorescent probes

artículo científico publicado en 2010

Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells

artículo científico publicado en 2003

Kiss and run exocytosis of dense core secretory vesicles

artículo científico publicado en 2004

LKB1 and AMPK differentially regulate pancreatic β-cell identity.

artículo científico publicado en 2014

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

artículo científico publicado en 2015

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo

artículo científico publicado en 2010

Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging

artículo científico publicado en 2013

Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo

artículo científico publicado en 2019

Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells

artículo científico publicado en 2020

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

artículo científico publicado en 2015

Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis

artículo científico

Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes

artículo científico publicado en 2016

Lipotoxicity disrupts incretin-regulated human β cell connectivity

artículo científico publicado en 2013

Live-cell imaging of vesicle trafficking and divalent metal ions by total internal reflection fluorescence (TIRF) microscopy

artículo científico publicado en 2013

Local and regional control of calcium dynamics in the pancreatic islet

artículo científico publicado en 2017

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects

artículo científico publicado en 2015

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

scientific article published on 01 November 2019

Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation

artículo científico publicado en 2020

Luciferase expression for ATP imaging: application to cardiac myocytes

artículo científico publicado en 2007

Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis

artículo científico publicado en 2005

Manipulation and Measurement of AMPK Activity in Pancreatic Islets

artículo científico publicado en 2018

Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells

artículo científico publicado en 2004

Metabolic and Functional Heterogeneity in Pancreatic β Cells

scientific article published on 13 August 2019

Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity

artículo científico publicado en 2020

Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.

artículo científico publicado en 2015

Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism

artículo científico publicado en 2005

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion

artículo científico publicado en 2004

MiR-184 expression is regulated by AMPK in pancreatic islets

artículo científico publicado en 2017

MiRNAs in β-Cell Development, Identity, and Disease.

scientific article published on January 2016

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

artículo científico publicado en 2018

MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines

artículo científico publicado en 2007

Minireview: intraislet regulation of insulin secretion in humans

artículo científico publicado en 2013

Mitochondria-associated endoplasmic reticulum membranes in insulin signaling

artículo científico publicado en 2014

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+.

artículo científico publicado en 2014

Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells

artículo científico publicado en 2009

Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes ⬇️

artículo científico publicado el 1 de agosto de 1998

Mitochondrial localization as a determinant of capacitative Ca2+ entry in HeLa cells

scientific article published on 01 December 2004

Modeling Type 2 Diabetes GWAS Candidate Gene Function in hESCs.

artículo científico publicado en 2016

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

artículo científico publicado en 2015

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion

artículo científico publicado en 2017

Morphometric anatomy of the lumbar sympathetic trunk with respect to the anterolateral approach to lumbar interbody fusion: a cadaver study.

artículo científico publicado en 2017

Multiple forms of "kiss-and-run" exocytosis revealed by evanescent wave microscopy

artículo científico publicado en 2003

Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells

scientific journal article

Neuronatin regulates pancreatic β cell insulin content and secretion

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

artículo científico publicado en 2015

Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).

artículo científico publicado en 2011

Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, november 28-30, 2016 - Israel

artículo científico publicado en 2018

Optical Control of Insulin Secretion Using an Incretin Switch.

artículo científico publicado en 2015

Optical control of insulin release using a photoswitchable sulfonylurea

artículo científico publicado en 2014

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia

artículo científico publicado en 2016

Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

artículo científico publicado en 2004

Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells

artículo científico publicado en 2012

Overexpression of lactate dehydrogenase A attenuates glucose‐induced insulin secretion in stable MIN‐6 β‐cell lines ⬇️

artículo científico publicado el 3 de julio de 1998

Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise

scientific journal article

Oxidative energy metabolism in equine tendon cells ⬇️

artículo científico publicado el 1 de marzo de 1997

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

artículo científico publicado en 2012

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Diet-Induced Obese Mice

artículo científico publicado en 2020

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

artículo científico publicado en 2017

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization

artículo científico publicado en 2010

Pancreatic islet secretion: gabbling via GABA

artículo científico publicado en 2019

Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria.

artículo científico publicado en 2014

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion.

artículo científico publicado en 2015

Pancreatic β-cell imaging in humans: fiction or option?

artículo científico

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

artículo científico publicado en 2020

Photoswitchable diacylglycerols enable optical control of protein kinase C.

artículo científico publicado en 2016

Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells

artículo científico publicado en 2007

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

artículo científico publicado en 2016

Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats

artículo científico publicado en 2016

RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis

artículo científico publicado en 2010

Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice

scientific article published on 20 May 2020

Regulating glucagon secretion: somatostatin in the spotlight

artículo científico publicado en 2009

Regulation of ATP production by mitochondrial Ca(2+).

artículo científico

Regulation of Mammalian Gene Expression by Glucose

artículo científico publicado en 2000

Regulation of mitochondrial glycerol-phosphate dehydrogenase by Ca2+ within electropermeabilized insulin-secreting cells (INS-1)

artículo científico publicado el 15 de diciembre de 1992

Remote control of glucose homeostasis in vivo using photopharmacology

artículo científico publicado en 2017

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study ⬇️

artículo científico publicado en 2021

Rfx6 maintains the functional identity of adult pancreatic β cells.

artículo científico publicado en 2014

Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells

artículo científico publicado en 2012

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

artículo científico publicado en 2003

Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing

artículo científico publicado en 2004

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets

artículo científico publicado en 2015

Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

artículo científico publicado en 2003

Roles of Ca2+ ions in the control of ChREBP nuclear translocation

artículo científico publicado en 2012

Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility.

artículo científico publicado en 2014

Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).

artículo científico publicado en 2003

SLC30A8 mutations in type 2 diabetes

artículo científico

SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome

artículo científico publicado en 2017

SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing

scientific journal article

Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression

artículo científico publicado en 2014

Secretory-granule dynamics visualized in vivo with a phogrin–green fluorescent protein chimaera ⬇️

artículo científico publicado el 1 de julio de 1998

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

artículo científico publicado en 2014

Sensors for measuring subcellular zinc pools

artículo científico publicado en 2018

Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

scientific article published on 20 May 2020

Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress

artículo científico publicado en 2008

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

artículo científico publicado en 2016

Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver

artículo científico publicado en 2006

Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells

artículo científico publicado en 2002

Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells

artículo científico publicado en 2006

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas

artículo científico publicado en 2020

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

artículo científico publicado en 2017

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

artículo científico publicado en 2008

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

artículo científico publicado en 2009

Targeting GLP-1 receptor trafficking to improve agonist efficacy.

artículo científico publicado en 2018

Temperature-sensitive random insulin granule diffusion is a prerequisite for recruiting granules for release

artículo científico publicado en 2004

The AMP-regulated kinase family: enigmatic targets for diabetes therapy

artículo científico publicado en 2008

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

artículo científico publicado en 2018

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

scientific article published on 17 March 2020

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

artículo científico publicado en 2014

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.

scientific article published on 25 May 2016

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

artículo científico publicado en 2015

The beta-cell in type 2 diabetes and in obesity

artículo científico publicado en 2008

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans

artículo científico publicado en 2018

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells

artículo científico publicado en 2012

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion

artículo científico publicado en 2012

The pancreatic beta-cell: birth, life and death

artículo científico publicado en 2008

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

artículo científico publicado en 2020

The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia

artículo científico publicado en 2007

The role of microRNAs in the pancreatic differentiation of pluripotent stem cells.

artículo científico publicado en 2014

The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation

scientific article published on 01 July 2020

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice

artículo científico publicado en 2017

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion

artículo científico publicado en 2015

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

artículo científico publicado en 2020

The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.

artículo científico publicado en 2015

The α-cell in diabetes mellitus

artículo científico publicado en 2018

Think zinc: New roles for zinc in the control of insulin secretion ⬇️

artículo científico publicado el 1 de enero de 2010

Transcription factor-7-like 2 () gene acts downstream of the / kinase to control mTOR signaling, β cell growth, and insulin secretion

article

Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratio in living cells

artículo científico publicado en 2014

When less is more: the forbidden fruits of gene repression in the adult β‐cell ⬇️

artículo científico publicado el 22 de noviembre de 2012

Zinc and diabetes

artículo científico publicado en 2016

Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes

artículo científico publicado en 2018

eZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn(2+) Imaging.

artículo científico publicado en 2015

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes

artículo científico publicado en 2019

miR-29a and miR-29b Contribute to Pancreatic β-Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1) ⬇️

artículo científico publicado el 6 de junio de 2011

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