Author response: Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

Chromatin 3D interaction analysis of theSTARD10locus unveilsFCHSD2as a new regulator of insulin secretion

Control of human pancreatic beta cell kinome by GLP-1R biased agonism

Differential CpG methylation atNnatin the early establishment of beta cell heterogeneity

Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice

ER calcium stores contribute to glucose-induced Ca2+waves and intercellular connectivity in mouse pancreatic islets

Effects of SGLT2 Ablation or Inhibition on Corticosterone Secretion in High-Fat-Fed Mice: Exploring a Nexus with Cytokine Levels

Exploration of individual beta cell function over time in vivo: effects of hyperglycemia and glucagon-like peptide-1 receptor (GLP1R) agonism

Expression of mini-G proteins specifically halt cognate GPCR trafficking and intracellular signalling

Glucose-dependent miR-125b is a negative regulator of β-cell function

In vivo functional profiling and structural characterisation of the human GLP1R A316T variant

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis

Investigating the pathogenicity of the recessiveHNF1Ap.A251T variant in monogenic diabetes using iPSC-derived beta-like cells

Leveraging hierarchical structures for genetic block interaction studies using the hierarchical transformer

Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells

Mature and immature β-cells both contribute to islet function and insulin release

MitofusinsMfn1andMfn2are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretion

Molecular phenotyping of single pancreatic islet leader beta cells by “Flash-Seq”

Multiple genetic variants at theSLC30A8locus affect local super-enhancer activity and influence pancreatic β-cell survival and function

Novel subgroups of type 2 diabetes based on multi-Omics profiling: an IMI-RHAPSODY Study

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells

Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells

Roles for the long non-coding RNAPax6os1/PAX6-AS1in pancreatic beta cell identity and function

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model ofGCK-MODY

The gene signatures of human alpha cells in types 1 and 2 diabetes indicate disease-specific pathways of alpha cell dysfunction

The mitochondrial Ca2+uniporter MCU is required for normal glucose-stimulated insulin secretionin vitroandin vivo

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Vertical sleeve gastrectomy lowers kidney SGLT2 expression in the mouse

Whole-body sorcin invalidation does not cause hypothalamic ER stress nor worsens obesity in C57BL/6 male mice fed a westernized diet