Lista de obras - Gerald J Atkins - Dominio Público Uruguay

1,25-Dihydroxyvitamin D3 and extracellular calcium promote mineral deposition via NPP1 activity in a mature osteoblast cell line MLO-A5.

artículo científico publicado en 2015

1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion

artículo científico publicado en 2015

A New Approach to Surgical Management of Tibial Plateau Fractures

artículo científico publicado en 2020

A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis.

artículo científico publicado en 2015

Absence of vitamin D receptor in mature osteoclasts results in altered osteoclastic activity and bone loss.

artículo científico publicado en 2017

Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer

artículo científico publicado en 2016

An update on primary hip osteoarthritis including altered Wnt and TGF-β associated gene expression from the bony component of the disease

artículo científico publicado en 2011

Analysis of vitamin D metabolism gene expression in human bone: evidence for autocrine control of bone remodelling

artículo científico

Anodized 3D-printed titanium implants with dual micro- and nano-scale topography promote interaction with human osteoblasts and osteocyte-like cells.

artículo científico publicado en 2016

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models

artículo científico publicado en 2016

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma

artículo científico publicado en 2017

Assigning trabecular bone material properties in finite element models simulating the pelvis before and after the development of peri-prosthetic osteolytic lesions

artículo científico publicado en 2022

Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion

artículo científico publicado en 2011

Biomimetic hydroxyapatite coating on glass coverslips for the assay of osteoclast activity in vitro

artículo científico publicado en 2009

Both ligand and VDR expression levels critically determine the effect of 1α,25-dihydroxyvitamin-D3 on osteoblast differentiation.

artículo científico publicado en 2017

Bril: a novel bone-specific modulator of mineralization

scientific journal article

Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice

artículo científico publicado en 2008

Changes in osteocyte density correspond with changes in osteoblast and osteoclast activity in an osteoporotic sheep model

artículo científico publicado en 2011

Characterization of drug-release kinetics in trabecular bone from titania nanotube implants.

artículo científico publicado en 2012

Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis.

artículo científico publicado en 2002

Circulating levels of TWEAK correlate with bone erosion in multiple myeloma patients

artículo científico publicado en 2010

Comparison of the biological effects of exogenous and endogenous 1,25-dihydroxyvitamin D3 on the mature osteoblast cell line MLO-A5.

artículo científico publicado en 2016

Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation.

artículo científico publicado en 2000

Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis

artículo científico publicado en 2010

Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo ⬇️

artículo científico publicado el 3 de enero de 2013

Current concepts of osteomyelitis: from pathological mechanisms to advanced research methods

scientific article published on 16 March 2020

Differential effects of 1,25-dihydroxyvitamin D on mineralisation and differentiation in two different types of osteoblast-like cultures ⬇️

artículo científico publicado el 7 de diciembre de 2012

Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?

artículo científico publicado en 2008

Drug diffusion, integration, and stability of nanoengineered drug-releasing implants in bone ex-vivo.

artículo científico publicado en 2015

Drug-releasing nano-engineered titanium implants: therapeutic efficacy in 3D cell culture model, controlled release and stability

artículo científico publicado en 2016

Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D3.

artículo científico publicado en 2015

Elevated Serum 25-Hydroxyvitamin D Levels Are Associated with Improved Bone Formation and Micro-Structural Measures in Elderly Hip Fracture Patients

scientific article published on 15 November 2019

Evidence for Gender-Specific Bone Loss Mechanisms in Periprosthetic Osteolysis

artículo científico publicado en 2019

Evidence for altered osteoclastogenesis in splenocyte cultures from Cyp27b1 knockout mice

artículo científico publicado en 2015

Evidence for altered osteoclastogenesis in splenocyte cultures from VDR knockout mice.

artículo científico publicado en 2017

Evidence that osteocyte perilacunar remodelling contributes to polyethylene wear particle induced osteolysis

artículo científico publicado en 2016

Expression of fibrillins and other microfibril-associated proteins in human bone and osteoblast-like cells

scientific article published on 01 July 2000

Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis

artículo científico publicado en 2010

Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells

artículo científico

First Australian report of vitamin D-dependent rickets type I

artículo científico publicado en 2014

Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis

artículo científico publicado en 2002

Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis

artículo científico publicado en 2019

Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium.

artículo científico publicado en 2005

Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma.

artículo científico publicado en 2014

Impaction bone grafting has potential as an adjunct to the surgical stabilisation of osteoporotic tibial plateau fractures: Early results of a case series.

artículo científico publicado en 2015

Isolation of osteocytes from human trabecular bone.

artículo científico publicado en 2016

Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3.

artículo científico publicado en 2007

Modulation of osteoclastic migration by metabolism of 25OH-vitamin D3.

artículo científico publicado en 2012

Novel Insights into Staphylococcus aureus Deep Bone Infections: the Involvement of Osteocytes.

artículo científico publicado en 2018

Novel targets of vitamin D activity in bone: action of the vitamin D receptor in osteoblasts, osteocytes and osteoclasts

artículo científico

Osteoblast-chondrocyte interactions in osteoarthritis

artículo científico publicado en 2014

Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption

artículo científico publicado en 2010

Osteocyte regulation of bone mineral: a little give and take.

artículo científico publicado en 2012

Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways

artículo científico publicado en 2019

Osteocytes: The master cells in bone remodelling

artículo científico publicado en 2016

Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor

artículo científico publicado en 2005

Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint.

artículo científico publicado en 2001

Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls.

artículo científico publicado en 2003

Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone

artículo científico publicado en 2001

Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management.

artículo científico publicado en 2013

Peroxidase Enzymes Regulate Collagen Biosynthesis and Matrix Mineralization by Cultured Human Osteoblasts

artículo científico publicado en 2015

Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.

artículo científico publicado en 2016

Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer

artículo científico publicado en 2014

Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro

artículo científico publicado en 2012

Postoperative weight bearing and patient reported outcomes at one year following tibial plateau fractures

artículo científico publicado en 2017

Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype.

artículo científico publicado en 2008

Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts

artículo científico publicado en 2009

RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone

artículo científico publicado en 2006

RANKL expression is related to the differentiation state of human osteoblasts.

artículo científico publicado en 2003

Recombinant sclerostin antagonises effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size

artículo científico publicado en 2017

Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli.

artículo científico publicado en 2014

Relationship between serum RANKL and RANKL in bone

artículo científico publicado en 2011

Reversal of established bone pathology in MPS VII mice following lentiviral-mediated gene therapy

artículo científico publicado en 2016

Role of polyethylene particles in peri-prosthetic osteolysis: A review ⬇️

artículo científico publicado el 18 de octubre de 2011

SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes.

artículo científico publicado en 2014

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism ⬇️

artículo científico publicado el 1 de julio de 2011

Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2.

artículo científico publicado en 2013

Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway

artículo científico publicado en 2011

Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss

artículo científico publicado en 2015

Sex-related differences in the skeletal phenotype of aged vitamin D receptor global knockout mice

artículo científico publicado en 2015

Skeletal characterization of an osteoblast-specific vitamin D receptor transgenic (ObVDR-B6) mouse model.

artículo científico publicado en 2015

TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis.

artículo científico publicado en 2011

TWEAK and TNF regulation of sclerostin: a novel pathway for the regulation of bone remodelling

artículo científico publicado en 2011

TWEAK is a novel arthritogenic mediator

scientific article published on 01 August 2006

The Late Osteoblast/Preosteocyte Cell Line MLO-A5 Displays Mesenchymal Lineage Plasticity and

artículo científico publicado en 2019

The local production of 1,25(OH)2D3 promotes osteoblast and osteocyte maturation

artículo científico

The metabolism of 25-(OH)vitamin D3 by osteoclasts and their precursors regulates the differentiation of osteoclasts.

artículo científico publicado en 2010

The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro.

artículo científico

The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation.

artículo científico publicado en 2013

The pleiotropic effects of vitamin D in bone

artículo científico

The proliferation and phenotypic expression of human osteoblasts on tantalum metal.

artículo científico publicado en 2004

The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis

artículo científico publicado en 2001

The skeleton as an intracrine organ for vitamin D metabolism

artículo científico publicado en 2008

Time dependent loss of trabecular bone in human tibial plateau fractures

scientific article published on 13 July 2018

Vitamin D metabolism within bone cells: effects on bone structure and strength

artículo científico publicado en 2011

Vitamin D receptor overexpression in osteoblasts and osteocytes prevents bone loss during vitamin D-deficiency.

artículo científico publicado en 2014

Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms.

artículo científico publicado en 2009

Lista de obras de Gerald J Atkins

1,25-Dihydroxyvitamin D3 and extracellular calcium promote mineral deposition via NPP1 activity in a mature osteoblast cell line MLO-A5.

1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion

A New Approach to Surgical Management of Tibial Plateau Fractures

A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis.

Absence of vitamin D receptor in mature osteoclasts results in altered osteoclastic activity and bone loss.

Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer

An update on primary hip osteoarthritis including altered Wnt and TGF-β associated gene expression from the bony component of the disease

Analysis of vitamin D metabolism gene expression in human bone: evidence for autocrine control of bone remodelling

Anodized 3D-printed titanium implants with dual micro- and nano-scale topography promote interaction with human osteoblasts and osteocyte-like cells.

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma

Assigning trabecular bone material properties in finite element models simulating the pelvis before and after the development of peri-prosthetic osteolytic lesions

Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion

Biomimetic hydroxyapatite coating on glass coverslips for the assay of osteoclast activity in vitro

Both ligand and VDR expression levels critically determine the effect of 1α,25-dihydroxyvitamin-D3 on osteoblast differentiation.

Bril: a novel bone-specific modulator of mineralization

Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice

Changes in osteocyte density correspond with changes in osteoblast and osteoclast activity in an osteoporotic sheep model

Characterization of drug-release kinetics in trabecular bone from titania nanotube implants.

Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis.

Circulating levels of TWEAK correlate with bone erosion in multiple myeloma patients

Comparison of the biological effects of exogenous and endogenous 1,25-dihydroxyvitamin D3 on the mature osteoblast cell line MLO-A5.

Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation.

Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis

Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo ⬇️

Current concepts of osteomyelitis: from pathological mechanisms to advanced research methods

Differential effects of 1,25-dihydroxyvitamin D on mineralisation and differentiation in two different types of osteoblast-like cultures ⬇️

Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?

Drug diffusion, integration, and stability of nanoengineered drug-releasing implants in bone ex-vivo.

Drug-releasing nano-engineered titanium implants: therapeutic efficacy in 3D cell culture model, controlled release and stability

Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D3.

Elevated Serum 25-Hydroxyvitamin D Levels Are Associated with Improved Bone Formation and Micro-Structural Measures in Elderly Hip Fracture Patients

Evidence for Gender-Specific Bone Loss Mechanisms in Periprosthetic Osteolysis

Evidence for altered osteoclastogenesis in splenocyte cultures from Cyp27b1 knockout mice

Evidence for altered osteoclastogenesis in splenocyte cultures from VDR knockout mice.

Evidence that osteocyte perilacunar remodelling contributes to polyethylene wear particle induced osteolysis

Expression of fibrillins and other microfibril-associated proteins in human bone and osteoblast-like cells

Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis

Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells

First Australian report of vitamin D-dependent rickets type I

Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis

Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis

Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium.

Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma.

Impaction bone grafting has potential as an adjunct to the surgical stabilisation of osteoporotic tibial plateau fractures: Early results of a case series.

Isolation of osteocytes from human trabecular bone.

Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3.

Modulation of osteoclastic migration by metabolism of 25OH-vitamin D3.

Novel Insights into Staphylococcus aureus Deep Bone Infections: the Involvement of Osteocytes.

Novel targets of vitamin D activity in bone: action of the vitamin D receptor in osteoblasts, osteocytes and osteoclasts

Osteoblast-chondrocyte interactions in osteoarthritis

Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption

Osteocyte regulation of bone mineral: a little give and take.

Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways

Osteocytes: The master cells in bone remodelling

Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor

Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint.

Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls.

Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone

Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management.

Peroxidase Enzymes Regulate Collagen Biosynthesis and Matrix Mineralization by Cultured Human Osteoblasts

Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.

Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer

Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro

Postoperative weight bearing and patient reported outcomes at one year following tibial plateau fractures

Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype.

Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts

RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone

RANKL expression is related to the differentiation state of human osteoblasts.

Recombinant sclerostin antagonises effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size

Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli.

Relationship between serum RANKL and RANKL in bone

Reversal of established bone pathology in MPS VII mice following lentiviral-mediated gene therapy

Role of polyethylene particles in peri-prosthetic osteolysis: A review ⬇️

SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes.

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism ⬇️

Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2.

Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway

Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss