Lista de obras - Ralph Mazitschek - Dominio Público Uruguay

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells

artículo científico publicado en 2007

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

artículo científico publicado en 2010

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria

artículo científico publicado en 2014

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells

artículo científico publicado en 2020

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum

artículo científico publicado en 2011

Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability

artículo científico publicado en 2013

Antiplasmodial activity of piperazine sulfonamides

artículo científico publicado en 2009

Bioorthogonal turn-on probes for imaging small molecules inside living cells

artículo científico publicado en 2010

Characterization of Plasmodium liver stage inhibition by halofuginone

artículo científico publicado en 2012

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

artículo científico publicado en 2010

Chemical interrogation of the malaria kinome

artículo científico publicado en 2014

Chemical phylogenetics of histone deacetylases

artículo científico publicado en 2010

Colorimetric high-throughput screen for detection of heme crystallization inhibitors

artículo científico publicado en 2009

Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

artículo científico publicado en 2014

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

artículo científico publicado en 2012

Development of a fluorescence polarization based assay for histone deacetylase ligand discovery

artículo científico publicado en 2008

Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

artículo científico publicado en 2003

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

artículo científico publicado en 2016

Efficient acid-catalyzed (18) F/(19) F fluoride exchange of BODIPY dyes

artículo científico publicado en 2014

Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER.

artículo científico publicado en 2009

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

artículo científico publicado en 2015

Fluorescence anisotropy imaging in drug discovery

artículo científico publicado en 2018

Frontispiece: Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

article by Vunnam Srinivasulu et al published 12 October 2017 in Chemistry—A European Journal

HDAC2 negatively regulates memory formation and synaptic plasticity.

artículo científico publicado en 2009

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

artículo científico publicado en 2017

HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells

artículo científico publicado en 2015

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

artículo científico publicado en 2012

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

artículo científico publicado en 2009

High-throughput screen for novel antimicrobials using a whole animal infection model

artículo científico publicado en 2009

Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection

artículo científico publicado en 2006

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

artículo científico publicado en 2009

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors

artículo científico publicado en 2011

In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

artículo científico publicado en 2011

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

artículo científico publicado en 2012

Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model

artículo científico publicado en 2015

Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks

artículo científico publicado en 2016

Local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice.

artículo científico publicado en 2004

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity

artículo científico publicado en 2006

Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging

artículo científico publicado en 2017

Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

artículo científico publicado en 2017

Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker

artículo científico publicado en 2003

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors

artículo científico publicado en 2002

On the inhibition of histone deacetylase 8

artículo científico publicado en 2010

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

artículo científico publicado en 2016

Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents

artículo científico publicado en 2014

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation

artículo científico publicado en 2012

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

artículo científico publicado en 2009

Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model

artículo científico publicado en 2014

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

artículo científico publicado en 2017

Structural origin of selectivity in class II-selective histone deacetylase inhibitors

artículo científico publicado en 2008

Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines

artículo científico publicado en 2009

Synthesis and biological evaluation of Santacruzamate-A based analogues

artículo científico publicado en 2017

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues

artículo científico publicado en 2005

Synthesis and biological investigation of novel tricyclic benzodiazepinedione-based RGD analogues

artículo científico publicado en 2002

Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging

artículo científico publicado en 2012

The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling

artículo científico publicado en 2019

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

artículo científico publicado en 2015

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.

artículo científico publicado en 2002

Treatment of obesity with celastrol

artículo científico publicado en 2015

Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice

artículo científico publicado en 2017

Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis

artículo científico publicado en 2009

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

artículo científico publicado en 2008

Lista de obras de Ralph Mazitschek

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum

Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability

Antiplasmodial activity of piperazine sulfonamides

Bioorthogonal turn-on probes for imaging small molecules inside living cells

Characterization of Plasmodium liver stage inhibition by halofuginone

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Chemical interrogation of the malaria kinome

Chemical phylogenetics of histone deacetylases

Colorimetric high-throughput screen for detection of heme crystallization inhibitors

Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Development of a fluorescence polarization based assay for histone deacetylase ligand discovery

Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

Efficient acid-catalyzed (18) F/(19) F fluoride exchange of BODIPY dyes

Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER.

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

Fluorescence anisotropy imaging in drug discovery

Frontispiece: Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

HDAC2 negatively regulates memory formation and synaptic plasticity.

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

High-throughput screen for novel antimicrobials using a whole animal infection model

Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors

In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model

Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks

Local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice.

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity

Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging

Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors

On the inhibition of histone deacetylase 8

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Structural origin of selectivity in class II-selective histone deacetylase inhibitors

Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines

Synthesis and biological evaluation of Santacruzamate-A based analogues

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues

Synthesis and biological investigation of novel tricyclic benzodiazepinedione-based RGD analogues

Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging

The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.

Treatment of obesity with celastrol

Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice

Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor