Lista de obras - Carsten Culmsee - Dominio Público Uruguay

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

artículo científico publicado en 2017

A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

artículo científico publicado en 2010

A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia.

artículo científico publicado en 2002

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

artículo científico publicado en 2001

AIF depletion provides neuroprotection through a preconditioning effect.

artículo científico publicado en 2012

Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia.

artículo científico publicado en 2012

Activation of SK2 channels preserves ER Ca²⁺ homeostasis and protects against ER stress-induced cell death

artículo científico publicado en 2015

Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium.

artículo científico publicado en 2001

Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

artículo científico publicado en 2006

Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.

artículo científico publicado en 2005

Apoptotic and antiapoptotic mechanisms in stroke.

artículo científico publicado en 2000

BID links ferroptosis to mitochondrial cell death pathways

artículo científico publicado en 2017

Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia

scientific journal article

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death.

artículo científico publicado en 2009

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

artículo científico publicado en 2008

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

artículo científico publicado en 2010

Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons.

artículo científico publicado en 2006

Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury

artículo científico publicado en 2008

Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

artículo científico publicado en 1999

Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance.

artículo científico publicado en 2015

Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.

artículo científico publicado en 1999

Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death

artículo científico publicado en 2021

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission.

artículo científico publicado en 2017

Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol.

artículo científico publicado en 2004

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

artículo científico publicado en 2016

Cylindromatosis mediates neuronal cell death in vitro and in vivo.

artículo científico publicado en 2018

Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.

artículo científico publicado en 2007

Downregulation of the psychiatric susceptibility gene Cacna1c promotes mitochondrial resilience to oxidative stress in neuronal cells.

artículo científico publicado en 2018

Effects of Cimicifuga racemosa extract Ze450 on mitochondria in models of oxidative stress in neuronal cells.

artículo científico publicado en 2018

Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.

artículo científico publicado en 2006

Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke.

artículo científico publicado en 2008

Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats

artículo científico publicado en 1999

Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia

article

Evidence for the involvement of Par-4 in ischemic neuron cell death

artículo científico publicado en 2001

Glucose-regulated protein 75 determines ER-mitochondrial coupling and sensitivity to oxidative stress in neuronal cells

artículo científico publicado en 2017

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

artículo científico publicado en 2008

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

artículo científico publicado en 2017

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

artículo científico publicado en 2001

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

scientific article published on 01 September 2000

Impedance measurement for real time detection of neuronal cell death.

artículo científico publicado en 2011

Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway

artículo científico publicado en 2006

Inhibition of Drp1 provides neuroprotection in vitro and in vivo.

artículo científico publicado en 2012

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.

artículo científico publicado en 2016

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress.

artículo científico publicado en 2014

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia

artículo científico publicado en 2011

Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain

artículo científico publicado en 2017

Metabolic switch induced by Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell death

scientific article published on 17 September 2018

Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways

artículo científico publicado en 2017

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis.

artículo científico publicado en 2018

N-acyl derivatives of 4-phenoxyaniline as neuroprotective agents

artículo científico publicado en 2014

NGF mediates the neuroprotective effect of the beta2-adrenoceptor agonist clenbuterol in vitro and in vivo: evidence from an NGF-antisense study.

artículo científico publicado en 1999

Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.

artículo científico publicado en 2002

Neurodegenerative disorders and ischemic brain diseases.

artículo científico publicado en 2001

Neuroprotection by Estrogens in a Mouse Model of Focal Cerebral Ischemia and in Cultured Neurons: Evidence for a Receptor-Independent Antioxidative Mechanism

article

Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways.

artículo científico publicado en 2004

Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis.

artículo científico publicado en 2005

Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.

artículo científico publicado en 2014

Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.

artículo científico publicado en 2002

Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia

artículo científico publicado en 2004

One protein, different cell fate: the differential outcome of depleting GRP75 during oxidative stress in neurons.

artículo científico publicado en 2018

Oxidative stress and neurodegeneration

artículo científico publicado en 2013

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

artículo científico publicado en 2007

Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition

artículo científico publicado en 2014

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

scientific journal article

Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons.

artículo científico publicado en 2012

Proteomic analysis reveals differences in protein expression in spheroid versus monolayer cultures of low-passage colon carcinoma cells

artículo científico publicado en 2007

Psychiatric risk gene Cacna1c determines mitochondrial resilience against oxidative stress in neurons.

artículo científico publicado en 2018

Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

artículo científico publicado en 2003

SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling.

artículo científico publicado en 2018

SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2.

artículo científico publicado en 2015

SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

artículo científico publicado en 2020

SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake

artículo científico publicado en 2017

Sex differences in neonatal mouse brain injury after hypoxia-ischemia and adaptaquin treatment

scientific article published on 28 July 2019

Small conductance Ca2+-activated K+ channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases

artículo científico publicado en 2017

Statins--increasing or reducing the risk of Parkinson's disease?

artículo científico publicado en 2010

Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat

artículo científico publicado en 2000

Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.

artículo científico publicado en 2006

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

artículo científico publicado en 2014

Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA delivery.

artículo científico publicado en 2007

Targeting Bid to prevent programmed cell death in neurons.

artículo científico publicado en 2006

Targeting beta2-adrenoceptors for neuroprotection after cerebral ischemia: is inhibition or stimulation best?

scientific article published on 01 January 2009

Targeting the p53 pathway to protect the neonatal ischemic brain.

artículo científico publicado en 2011

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo.

artículo científico publicado en 2009

Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS.

artículo científico publicado en 2008

The beta2-adrenoceptor agonist clenbuterol modulates Bcl-2, Bcl-xl and Bax protein expression following transient forebrain ischemia.

artículo científico publicado en 1999

The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.

artículo científico publicado en 2000

The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat

artículo científico publicado en 2000

The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.

artículo científico publicado en 2015

The neuroprotective role of microglial cells against amyloid beta-mediated toxicity in organotypic hippocampal slice cultures

scientific article published on 26 November 2019

The serine protease inhibitor TLCK attenuates intrinsic death pathways in neurons upstream of mitochondrial demise.

artículo científico publicado en 2014

The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons.

artículo científico publicado en 2004

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

scientific article published on March 2016

Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage.

artículo científico publicado en 2002

Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity.

artículo científico publicado en 2014

Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat.

artículo científico publicado en 1998

[Pharmacotherapy of Parkinson's disease : Aspects of drug safety].

artículo científico publicado en 2017

siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing.

artículo científico publicado en 2007

α1-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity.

artículo científico publicado en 2014

Lista de obras de Carsten Culmsee

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia.

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

AIF depletion provides neuroprotection through a preconditioning effect.

Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia.

Activation of SK2 channels preserves ER Ca²⁺ homeostasis and protects against ER stress-induced cell death

Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium.

Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.

Apoptotic and antiapoptotic mechanisms in stroke.

BID links ferroptosis to mitochondrial cell death pathways

Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death.

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons.

Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury

Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance.

Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.

Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission.

Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol.

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

Cylindromatosis mediates neuronal cell death in vitro and in vivo.

Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.

Downregulation of the psychiatric susceptibility gene Cacna1c promotes mitochondrial resilience to oxidative stress in neuronal cells.

Effects of Cimicifuga racemosa extract Ze450 on mitochondria in models of oxidative stress in neuronal cells.

Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.

Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke.

Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats

Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia

Evidence for the involvement of Par-4 in ischemic neuron cell death

Glucose-regulated protein 75 determines ER-mitochondrial coupling and sensitivity to oxidative stress in neuronal cells

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

Impedance measurement for real time detection of neuronal cell death.

Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway

Inhibition of Drp1 provides neuroprotection in vitro and in vivo.

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress.

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia

Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain

Metabolic switch induced by Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell death

Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis.

N-acyl derivatives of 4-phenoxyaniline as neuroprotective agents

NGF mediates the neuroprotective effect of the beta2-adrenoceptor agonist clenbuterol in vitro and in vivo: evidence from an NGF-antisense study.

Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.

Neurodegenerative disorders and ischemic brain diseases.

Neuroprotection by Estrogens in a Mouse Model of Focal Cerebral Ischemia and in Cultured Neurons: Evidence for a Receptor-Independent Antioxidative Mechanism

Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways.

Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis.

Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.

Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.

Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia

One protein, different cell fate: the differential outcome of depleting GRP75 during oxidative stress in neurons.

Oxidative stress and neurodegeneration

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons.

Proteomic analysis reveals differences in protein expression in spheroid versus monolayer cultures of low-passage colon carcinoma cells

Psychiatric risk gene Cacna1c determines mitochondrial resilience against oxidative stress in neurons.

Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling.

SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2.

SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake

Sex differences in neonatal mouse brain injury after hypoxia-ischemia and adaptaquin treatment

Small conductance Ca2+-activated K+ channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases

Statins--increasing or reducing the risk of Parkinson's disease?

Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat

Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA delivery.